Red blood cell endothelial nitric oxide synthase: A major player in regulating cardiovascular health
British Journal of Pharmacology, EarlyView., 2023 Abstract Red blood cells (RBCs) have traditionally been seen as simple carriers of gases and nutrients in the body. One important non‐canonical function of RBCs in the cardiovascular system is the regulation of nitric oxide (NO) metabolism. It has been shown that RBCs can scavenge NO, transport NO metabolites and produce NO in hypoxic conditions ...
Anthea LoBue +7 more
wiley +1 more source
Synthesis of guanosine tetra- and pentaphosphates by the obligately anaerobic bacterium Bacteroides thetaiotaomicron in response to molecular oxygen [PDF]
, 1979 Thomas L. Glass +3 more
openalex +1 more source
Guanosine and its modified derivatives are endogenous ligands for TLR7.
International Immunology, 2016 Takuma Shibata +12 more
semanticscholar +1 more source
The emerging role of Nrf2 in heart failure: From cardioprotection to therapeutic approaches
ESC Heart Failure, EarlyView.Nrf2 signalling is impaired in heart failure, contributing to oxidative stress, mitochondrial dysfunction, and ferroptosis, which drive neurohormonal activation, inflammation, and ischaemia‐reperfusion injury. This loss of Nrf2 activity exacerbates hypertension, diabetic cardiomyopathy, and cardiotoxicity, accelerating progression to overt heart ...
Emiliano Fiori +9 more
wiley +1 more source
The Isolation and Synthesis of Guanosine Diphosphate Glucose
, 1962 Don M. Carlson, R.G. Hansen
openalex +1 more source
European Journal of Heart Failure, EarlyView.Abstract Aims Heart failure with preserved ejection fraction (HFpEF) is a major healthcare burden with limited treatment options. Geranylgeranylacetone (GGA) has been shown to improve myocardial compliance and endothelial function in preclinical models.
Soufiane Nassiri +11 more
wiley +1 more source
Mutation of an inosine-producing strain of Bacillus subtilis to DL-methionine sulfoxide resistance for guanosine production [PDF]
, 1977 Hideo Matsui +3 more
openalex +1 more source
THE ENZYMATIC SYNTHESIS OF GUANOSINE DIPHOSPHATE COLITOSE BY A MUTANT STRAIN OF ESCHERICHIA COLI
, 1962 Edward C. Heath, Alan D. Elbein
openalex +1 more source
Kinetics of the template-directed oligomerization of guanosine 5'-phosphate-2-methylimidazolide: Effect of temperature on individual steps of reactionion [PDF]
Non-enzymatic, template-directed reactions have been proposed as models for prebiological polynucleotide synthesis. Chemically activated mononucleotides react in the presence of a polynucleotide, acting as the template in a Watson-Crick base-pairing ...
Alberas, D. J. +2 more
core +1 more source