Results 191 to 200 of about 225,684 (400)

Effects of geranylgeranylacetone on diastolic and microvascular function in patients with heart failure with a preserved ejection fraction: A phase 2, randomized, placebo‐controlled, crossover trial

European Journal of Heart Failure, EarlyView.
Abstract Aims Heart failure with preserved ejection fraction (HFpEF) is a major healthcare burden with limited treatment options. Geranylgeranylacetone (GGA) has been shown to improve myocardial compliance and endothelial function in preclinical models.
Soufiane Nassiri, Geert H.D. Voordes, Loek van Heerebeek, Daniël H. van Raalte, Marianne C. Verhaar, Daan J. Touw, Merle M. Krebber, Dirk J. Duncker, Etto C. Eringa, M. Louis Handoko, Adriaan A. Voors, on behalf of the RECONNEXT Consortium   +11 more
wiley   +1 more source

Covalent Guanosine Mimetic Inhibitors of G12C KRAS.

ACS Medicinal Chemistry Letters, 2017
Yuan Xiong, Jia Lu, J. Hunter, Lianbo Li, D. Scott, H. Choi, S. M. Lim, A. Manandhar, S. Gondi, Taebo Sim, K. Westover, N. Gray   +11 more
semanticscholar   +1 more source

FORMATION OF GUANOSINE DIPHOSPHATE FUCOSE FROM GUANOSINE DIPHOSPHATE MANNOSE [PDF]

Journal of the American Chemical Society, 1958
openaire   +3 more sources

Adverse Outcome Pathways Applied to Space Radiation Research

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT Long‐duration spaceflight exposes astronauts to various stressors that can alter human physiology, potentially causing immediate and long‐term health effects. These stressors can damage biomolecules, cells, tissues, and organs, leading to adverse outcomes.
Vinita Chauhan, Veronica S. Grybas, Devyn Hoopfer, Casey Higginson, Elizabeth A. Ainsbury, Omid Azimzadeh, Afshin Beheshti, Steve Blattnig, Marjan Boerma, Sylvain V. Costes, Stephen Doty, Christelle Adam‐Guillermin, Nobuyuki Hamada, Patricia Hinton, Janice L. Huff, Robert Reynolds, Ruth C. Wilkins, Scott Wood, Carole L. Yauk   +18 more
wiley   +1 more source

Guanosine Diphosphate d-glycero-d-manno-Heptose

, 1962
Victor Ginsburg, Paul J. O’Brien, Clara W. Hall   +2 more
openalex   +1 more source

Free 3′‐OH Group of the Terminal Adenosine of the tRNA Molecule Is Essential for the Synthesis in vitro of Guanosine Tetraphosphate and Pentaphosphate in a Ribosomal System from Escherichia coli [PDF]

, 1976
Mathias Sprinzl, Dietmar Richter
openalex   +1 more source

D‐Mannose Alleviates Type 2 Diabetes and Rescues Multi‐Organ Deteriorations by Controlling Release of Pathological Extracellular Vesicles

Exploration, EarlyView.
In this study, Zhang and colleagues show that drinking‐water supplementation of D‐mannose serves as an effective and potential therapeutic of type 2 diabetes, with improvement of both liver health and bone mass. The effect is exerted through suppressing macrophage release of extracellular vesicles based on metabolic control of CD36 expression.
Sha Zhang, Kai Zhang, Chen‐Xi Zheng, Ying‐Feng Gao, Guo‐Rong Deng, Xu Zhang, Yuan Yuan, Ting Jia, Si‐Yuan Tang, Guang‐Xiang He, Zhen Gong, Na Zhao, Bo Ma, Hua Tian, Hong Zhang, Zhe Li, Yong‐Chang Di‐Wu, Yi‐Han Liu, Liang Kong, Jing Ma, Yan Jin, Bing‐Dong Sui   +21 more
wiley   +1 more source

Coapplication of Adenine with Inosine or Guanosine Supports Rapid ATP Restoration by ATP-deprived Cultured Primary Astrocytes. [PDF]

Neurochem Res
Karger G, Dringen R.
europepmc   +1 more source

Uric Acid‐Lowering and Anti‐Hyperuricemia Effects of Plant‐Based Nutraceuticals and Foods: A Review

Food Chemistry International, EarlyView.
Increased UA production and/or decreased UA secretion cause hyperuricemia. Effects and mechanism of flavonoids in reducing UA are summarized. Terpenoids, saponins, alkaloids, vitamin C, polysaccharides, peptides are effective. Plant‐based foods with UA‐lowering ability are reviewed.
Linwei He, Wenjian Yang, Jianhui Liu
wiley   +1 more source

The Formation of Guanosine-Nucleotide . Elongation-Factor-G . Ribosome Complexes on Free 70-S Ribosomes, 50-S Subunits, and Polysomes. A Comparative Study [PDF]

, 1977
María J. San-Millán, David VAZQUEZ, Juan Modolell   +2 more
openalex   +1 more source