Food Frontiers, EarlyView.This study unveils how ASIV reverses diabetic nephropathy by restoring Gna13‐K363 acetylation and reprogramming purine metabolism. Using spatial metabolomics and acetylproteomics, we identified zonation‐specific purine dysregulation in diabetic kidneys, with ASIV normalizing metabolite distribution (hypoxanthine, cAMP, guanine) and targeting Gna13 ...
Shi Qiu +13 more
wiley +1 more source
The intrinsic preference of guanosine bases for cleavage-facilitating interactions with phosphodiester moieties in RNA anions revealed by base modifications and mass spectrometry. [PDF]
Nucleic Acids ResPloner A +5 more
europepmc +1 more source
Studies of Nucleosides and Nucleotides. XXX. Syntheses of 8-Substitute Guanosine Derivatives
, 1966 Morio Ikehara, Kei Muneyama
openalex +2 more sources
ANP-ing Up Diabetes: Impaired Natriuretic Peptide Action in Muscle Forms a Mechanistic Link Between Obesity and Diabetes [PDF]
, 2015 Cleasby, M E
core +1 more source
Kinetics of the template-directed oligomerization of guanosine 5'-phosphate-2-methylimidazolide: Effect of temperature on individual steps of reactionion [PDF]
Non-enzymatic, template-directed reactions have been proposed as models for prebiological polynucleotide synthesis. Chemically activated mononucleotides react in the presence of a polynucleotide, acting as the template in a Watson-Crick base-pairing ...
Alberas, D. J. +2 more
core +1 more source
Food Safety and Health, EarlyView.trans‐ferulic acid and sinapic acid could be used to distinguish Chinese ginseng from American ginseng. Panax quinquefolius from China and the United States produced unique metabolites and phenolic compounds. ABSTRACT Currently, there is a relative paucity of comparative studies on the metabolites of American ginseng from different geographical sources.
Dan Li +6 more
wiley +1 more source
Two Decades of Optogenetic Tools: A Retrospective and a Look Ahead
Advanced Genetics, EarlyView.Optogenetics provides up to millisecond scale, cell type‐specific control of biology using light‐sensitive proteins. This review chronicles two decades of tool development, from microbial rhodopsins and photoactivated enzymes to allosteric switches, surveys broad applications in neuroscience, molecular and cell biology, cardiology, immunology, and ...
Xiao Duan, Mo Zhu, Shiqiang Gao
wiley +1 more source
Further Evidence for a S-Syn Correlation in the Purine(β)ribosides: The Solution Conformation of Two Tricyclic Analogs of Adenosine and Guanosine [PDF]
, 1979 G. Klimke +2 more
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Absorption of pyrimidines, purines, and nucleosides by Co, Ni, Cu and Fe /III-montmorillonite /clay-organic studies XIII/ [PDF]
Absorption of pyrimidines, purines, and nucleosides by copper, nickel, cobalt, and iron ...
Brindley, G. W. +2 more
core +1 more source
Screening and evaluation of purines-degrading lactic acid bacteria isolated from traditional fermented foods in Yunnan Province and their uric acid-lowering effects <i>in vivo</i>. [PDF]
Front MicrobiolLiu Z +7 more
europepmc +1 more source