Results 271 to 280 of about 201,939 (380)

Plant Purine Nucleoside Catabolism Employs a Guanosine Deaminase Required for the Generation of Xanthosine in Arabidopsis[W]

The Plant Cell, 2013
Kathleen Dahncke, C. Witte
semanticscholar   +1 more source

Y12C mutation disrupts IMPDH cytoophidia and alters cancer metabolism

The FEBS Journal, EarlyView.
IMPDH, the rate‐limiting enzyme for de novo GTP synthesis, can form polymers and cytoophidia to enhance activity by reducing GTP inhibition. In this study, a Y12C mutation in IMPDH2 was introduced via ABEmax base‐editing in human cancer cell lines to disrupt IMPDH polymerisation.
Chia‐Chun Chang, Min Peng, Gerson Dierley Keppeke, Li‐Kuang Tsai, Ziheng Zhang, Li‐Mei Pai, Li‐Ying Sung, Ji‐Long Liu   +7 more
wiley   +1 more source

Purine Metabolism and Dystonia: Perspectives of a Long-Promised Relationship. [PDF]

Ann Neurol
Sorrentino U, O'Neill AG, Kollman JM, Jinnah HA, Zech M.   +4 more
europepmc   +1 more source

Conserved function of a RasGEF‐mediated pathway in the metabolic compensation of the circadian clock

The FEBS Journal, EarlyView.
Metabolic compensation of the circadian clock is essential for stabilizing the period of endogenous timekeeping in environments with significant nutrient fluctuations. In this study, we demonstrate that RasGEF (SOS1)‐mediated signaling, which is influenced by metabolic conditions, supports the robust function of the circadian clock under low glucose ...
Orsolya Sárkány, Anita Szőke, Aladár Pettkó‐Szandtner, Eszter Éva Kálmán, Michael Brunner, Norbert Gyöngyösi, Krisztina Káldi   +6 more
wiley   +1 more source

Membrane-Mediated Action of Phosphodiesterase 5 Inhibitors. [PDF]

Pharmaceutics
Malykhina AI, Efimova SS, Ostroumova OS.
europepmc   +1 more source

A Guanosine-Centric Mechanism for RNA Chaperone Function

Science, 2013
Jacob K. Grohman, R. Gorelick, Colin R. Lickwar, J. Lieb, Brian D. Bower, Brent M. Znosko, K. Weeks   +6 more
semanticscholar   +1 more source

Primary cutaneous NUT adnexal carcinoma: morphologic, genetic and methylation analysis of seven new cases with comparison to extracutaneous NUT carcinoma and NUTM1‐rearranged porocarcinoma

Histopathology, EarlyView.
Microscopic features of a NUTM1 adnexal carcinoma magnification. This neoplasm consisted of large, poorly demarcated tumors, sometimes ulcerated infiltrated the dermis and subcutaneous tissue (HPS ×10). The lesions were organized in strands, cords and larger solid nests of poorly differentiated cells characterized by enlarged, irregular nuclei (HPS ×20)
Mélanie Legrand, Baptiste Louveau, Amélie Osio, Anne Tallet, Eduardo Calonje, Jean‐Yves Scoazec, Arnaud de la Fouchardiere, Franck Tirode, Andreas Von Deimling, Klaus Busam, Ahmed Shah, Ashley Flaman, Fanélie Jouenne, Samia Mourah, Daniel Pissaloux, Sylvie Lantuejoul, Christopher A French, Keisuke Goto, Bernard Cribier, Carina A Dehner, Ahmed K Alomari, Christopher DM Fletcher, John Hanna, Nicolas Macagno, Maxime Battistella, Thibault Kervarrec   +25 more
wiley   +1 more source

Bidirectional regulation of the cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon gene pathway and its impact on hepatocellular carcinoma. [PDF]

World J Gastrointest Oncol
Nie AY, Xiao ZH, Deng JL, Li N, Hao LY, Li SH, Hu XY.   +6 more
europepmc   +1 more source

Gliopreventive effects of guanosine against glucose deprivation in vitro

Purinergic Signalling Purinergic Signalling, 2013
André Quincozes-Santos, L. Bobermin, D. G. Souza, Bruna Bellaver, C. Gonçalves, D. O. Souza   +5 more
semanticscholar   +1 more source

Canagliflozin protects cardiovascular function in type 2 diabetic coronary artery disease by regulating natriuretic peptide B

Journal of Diabetes Investigation, EarlyView.
Canagliflozin regulated the cyclic guanosine monophosphate (cGMP)‐protein kinase 1‐α signaling pathway through the natriuretic peptide B gene, thereby improving cell viability, apoptosis, and reactive oxygen species levels, and ultimately protecting cardiac function in type 2 diabetic patients with coronary artery disease.
Jiarui Zhang, Lichenlu Huang, Yongqin Zheng, Ji Yang, Xiaopei Wu, Jundong He   +5 more
wiley   +1 more source