Results 271 to 280 of about 201,939 (380)

Y12C mutation disrupts IMPDH cytoophidia and alters cancer metabolism

open access: yesThe FEBS Journal, EarlyView.
IMPDH, the rate‐limiting enzyme for de novo GTP synthesis, can form polymers and cytoophidia to enhance activity by reducing GTP inhibition. In this study, a Y12C mutation in IMPDH2 was introduced via ABEmax base‐editing in human cancer cell lines to disrupt IMPDH polymerisation.
Chia‐Chun Chang   +7 more
wiley   +1 more source

Conserved function of a RasGEF‐mediated pathway in the metabolic compensation of the circadian clock

open access: yesThe FEBS Journal, EarlyView.
Metabolic compensation of the circadian clock is essential for stabilizing the period of endogenous timekeeping in environments with significant nutrient fluctuations. In this study, we demonstrate that RasGEF (SOS1)‐mediated signaling, which is influenced by metabolic conditions, supports the robust function of the circadian clock under low glucose ...
Orsolya Sárkány   +6 more
wiley   +1 more source

Membrane-Mediated Action of Phosphodiesterase 5 Inhibitors. [PDF]

open access: yesPharmaceutics
Malykhina AI, Efimova SS, Ostroumova OS.
europepmc   +1 more source

A Guanosine-Centric Mechanism for RNA Chaperone Function

open access: yesScience, 2013
Jacob K. Grohman   +6 more
semanticscholar   +1 more source

Primary cutaneous NUT adnexal carcinoma: morphologic, genetic and methylation analysis of seven new cases with comparison to extracutaneous NUT carcinoma and NUTM1‐rearranged porocarcinoma

open access: yesHistopathology, EarlyView.
Microscopic features of a NUTM1 adnexal carcinoma magnification. This neoplasm consisted of large, poorly demarcated tumors, sometimes ulcerated infiltrated the dermis and subcutaneous tissue (HPS ×10). The lesions were organized in strands, cords and larger solid nests of poorly differentiated cells characterized by enlarged, irregular nuclei (HPS ×20)
Mélanie Legrand   +25 more
wiley   +1 more source

Gliopreventive effects of guanosine against glucose deprivation in vitro

open access: yesPurinergic Signalling Purinergic Signalling, 2013
André Quincozes-Santos   +5 more
semanticscholar   +1 more source

Canagliflozin protects cardiovascular function in type 2 diabetic coronary artery disease by regulating natriuretic peptide B

open access: yesJournal of Diabetes Investigation, EarlyView.
Canagliflozin regulated the cyclic guanosine monophosphate (cGMP)‐protein kinase 1‐α signaling pathway through the natriuretic peptide B gene, thereby improving cell viability, apoptosis, and reactive oxygen species levels, and ultimately protecting cardiac function in type 2 diabetic patients with coronary artery disease.
Jiarui Zhang   +5 more
wiley   +1 more source

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