Results 271 to 280 of about 238,540 (308)

Vaspin identified as a DNA‐binding serpin with functional consequences for protease inhibition

open access: yesThe FEBS Journal, EarlyView.
Vaspin is a serpin that is expressed in skin, adipose tissue, and liver. It binds to single‐ and double‐stranded DNA with high affinity. This binding is unaffected by mutation of the known heparin‐binding site, accelerates the inhibition of the inflammatory protease KLK7, and may contribute to vaspin's nuclear localization.
Kevin Möhlis   +9 more
wiley   +1 more source

Binding of Bacillus subtilis dynamin‐like protein DynA to the bacterial membrane is essential for effective phage defense

open access: yesThe FEBS Journal, EarlyView.
The bacterial dynamin‐like protein DynA from Bacillus subtilis plays a key role in phage defense. It binds the plasma membrane through a unique paddle domain in its D1 subunit. This membrane association is essential for its protective function, likely preventing explosive membrane rupture following phage infection.
Samia Shafqat   +2 more
wiley   +1 more source

Guanine Crystal Formation at Physiological pH. [PDF]

open access: yesCryst Growth Des
Tah Roy B   +8 more
europepmc   +1 more source

The importin‐alpha superfamily engages in ethylene signaling by shuttling ETHYLENE INSENSITIVE 2 from the endoplasmic reticulum to the nucleus

open access: yesThe FEBS Journal, EarlyView.
The plant hormone ethylene regulates plant growth, ripening, senescence, and stress responses. The hormonal signal transmission, from receptors at the ER membrane to the transcriptional regulators in the nucleus, is still not completely understood.
Fabian Wynen   +7 more
wiley   +1 more source

A disubstituted aniline probe for enhanced peroxidase-based proximal protein labelling. [PDF]

open access: yesRSC Chem Biol
Kaewsapsak P   +15 more
europepmc   +1 more source

Dynamics of the CD9 interactome during bacterial infection of epithelial cells by proximity labelling proteomics

open access: yesThe FEBS Journal, EarlyView.
We describe the CD9 interactome in epithelial cells for the first time. The interactome is diverse and dynamic and changes dependent on infection with specific bacteria. We validate these data by showing functional interaction between CD9 with CD44 or CD147. We therefore demonstrate that CD9 is a universal organiser of bacterial adhesion platforms able
Paige A. Wolverson   +5 more
wiley   +1 more source

Transcriptional regulation of human NMNAT2: insights from 3D genome sequencing and bioinformatics

open access: yesThe FEBS Journal, EarlyView.
NMNAT2 is a valuable drug target, as low levels increase the risk of neurodegeneration. We employed 4C‐seq to identify NMNAT2 regulatory regions in the human genome, revealing distinct interactomes of the NMNAT2 promoter in undifferentiated and neuron‐like SH‐SY5Y cells. Additionally, we uncovered NMNAT2‐associated genes and transcription factors. This
Yu Chen Chang   +5 more
wiley   +1 more source

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