Results 271 to 280 of about 201,939 (380)
Y12C mutation disrupts IMPDH cytoophidia and alters cancer metabolism
IMPDH, the rate‐limiting enzyme for de novo GTP synthesis, can form polymers and cytoophidia to enhance activity by reducing GTP inhibition. In this study, a Y12C mutation in IMPDH2 was introduced via ABEmax base‐editing in human cancer cell lines to disrupt IMPDH polymerisation.
Chia‐Chun Chang+7 more
wiley +1 more source
Purine Metabolism and Dystonia: Perspectives of a Long-Promised Relationship. [PDF]
Sorrentino U+4 more
europepmc +1 more source
Conserved function of a RasGEF‐mediated pathway in the metabolic compensation of the circadian clock
Metabolic compensation of the circadian clock is essential for stabilizing the period of endogenous timekeeping in environments with significant nutrient fluctuations. In this study, we demonstrate that RasGEF (SOS1)‐mediated signaling, which is influenced by metabolic conditions, supports the robust function of the circadian clock under low glucose ...
Orsolya Sárkány+6 more
wiley +1 more source
Membrane-Mediated Action of Phosphodiesterase 5 Inhibitors. [PDF]
Malykhina AI, Efimova SS, Ostroumova OS.
europepmc +1 more source
A Guanosine-Centric Mechanism for RNA Chaperone Function
Jacob K. Grohman+6 more
semanticscholar +1 more source
Microscopic features of a NUTM1 adnexal carcinoma magnification. This neoplasm consisted of large, poorly demarcated tumors, sometimes ulcerated infiltrated the dermis and subcutaneous tissue (HPS ×10). The lesions were organized in strands, cords and larger solid nests of poorly differentiated cells characterized by enlarged, irregular nuclei (HPS ×20)
Mélanie Legrand+25 more
wiley +1 more source
Bidirectional regulation of the cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon gene pathway and its impact on hepatocellular carcinoma. [PDF]
Nie AY+6 more
europepmc +1 more source
Gliopreventive effects of guanosine against glucose deprivation in vitro
André Quincozes-Santos+5 more
semanticscholar +1 more source
Canagliflozin regulated the cyclic guanosine monophosphate (cGMP)‐protein kinase 1‐α signaling pathway through the natriuretic peptide B gene, thereby improving cell viability, apoptosis, and reactive oxygen species levels, and ultimately protecting cardiac function in type 2 diabetic patients with coronary artery disease.
Jiarui Zhang+5 more
wiley +1 more source