Results 281 to 290 of about 266,483 (401)

Phosphodiesterase‐5 Inhibition and Alzheimer's Disease Risk: A Mendelian Randomisation Study

open access: yesAging Cell, EarlyView.
Preclinical studies suggest PDE5 inhibitors may improve cognition, but observational evidence on Alzheimer's disease (AD) risk is mixed. We performed a cis‐Mendelian randomisation analysis across four AD genome‐wide association studies (GWAS) datasets and a sex‐stratified analysis using UK Biobank data.
Marta Alcalde‐Herraiz   +9 more
wiley   +1 more source

A Guanosine-Centric Mechanism for RNA Chaperone Function

open access: yesScience, 2013
Jacob K. Grohman   +6 more
semanticscholar   +1 more source

Pharmacokinetics, pharmacodynamics, and safety interaction study of tunodafil hydrochloride and alcohol: A randomized, blinded, placebo‐controlled, three‐cycle crossover study in Chinese healthy men

open access: yesAndrology, EarlyView.
Abstract Objectives This study aimed to evaluate the pharmacodynamic effects of administering tunodafil hydrochloride with alcohol on blood pressure and heart rate in healthy Chinese males, and to investigate the mutual pharmacokinetic interactions and safety of the combination.
Dingyuan Hu   +18 more
wiley   +1 more source

Posttransfusion recovery, quality, and metabolism of short- and long-term stored platelets during controlled inflammation. [PDF]

open access: yesBlood Adv
van Wonderen SF   +19 more
europepmc   +1 more source

Gliopreventive effects of guanosine against glucose deprivation in vitro

open access: yesPurinergic Signalling Purinergic Signalling, 2013
André Quincozes-Santos   +5 more
semanticscholar   +1 more source

Comparative efficacy of combination therapy including regenerative therapies versus monotherapy for erectile dysfunction: A systematic review and meta‐analysis

open access: yesAndrology, EarlyView.
Abstract Background and objective The Current European Association of Urology guidelines do not provide recommendation for combination of regenerative therapies with standard therapies for erectile dysfunction. The aim of this study was to compare the efficacy of combined regenerative therapy with monotherapy for erectile dysfunction.
Alberto Quistini   +12 more
wiley   +1 more source

Pyruvate kinase directly generates GTP in glycolysis, supporting growth and contributing to guanosine toxicity. [PDF]

open access: yesmBio
She F   +9 more
europepmc   +1 more source

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