Results 281 to 290 of about 236,112 (356)

Determination and quantification of cyclic guanosine- and cyclic adenosine monophosphate (cGMP and cAMP) in human plasma and animal tissues by HILIC SPE in combination with LC-MS/MS [PDF]

, 2012
Lynen, Frederic, Sandra, Patrick, Van Damme, Thomas, Zhang, Yanhua   +3 more
core  

Targeting acetylated high mobility group box 1 protein (HMGB1) and toll‐like receptor (TLR4) interaction to alleviate hypertension and neuroinflammation in fructose‐fed rats

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Our previous study reported that fructose intake increased systemic blood pressure and reduced nitric oxide (NO) in the nucleus tractus solitarius (NTS) due to oxidative stress and neuroinflammation. However, it remains unclear how reactive oxygen species (ROS) reduce NO and how this process impacts neuroinflammation in ...
Yu‐Te Lin, Chiu‐Yi Ho, Gwo‐Ching Sun, Tzyy‐Yue Wong, Michael Hsiao, Ching‐Jiunn Tseng, Pei‐Wen Cheng   +6 more
wiley   +1 more source

Mycophenolate mofetil directly modulates myeloid viability and pro-fibrotic activation of human macrophages. [PDF]

Rheumatology (Oxford)
Morris EA, Parvizi R, Orzechowski NM, Whitfield ML, Pioli PA.   +4 more
europepmc   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

Controlled Delivery and Light-Induced Release of Magic Spot Nucleotides in Escherichia coli

Popp C, Moser P, Liu X, Freitag J, Prucker I, Zscherp R, Wang X, Klahn P, Koch H, Bange G, Jessen HJ.   +10 more
europepmc   +1 more source

Comparative analysis of hyperuricemia induction methods and probiotic interventions in mice. [PDF]

Curr Res Microb Sci
Wang Y, Zhang H, Liu S, Sun S, Ren W, Wang T, Zhang S, Yao H, Jin C, Wu N.   +9 more
europepmc   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Modeling and Optimization of Microwave Vacuum Drying for Pinelliae Rhizoma: Integrating Drying Kinetics, Artificial Neural Networks, and Quality Preservation. [PDF]

Food Sci Nutr
Wang P, Yang X, Huang X, Ma G, Zhang S, Wang S, Wang M, Zhu Z, Xu Y, Zang Z, Liu X.   +10 more
europepmc   +1 more source

Biosynthesis of Guanosine Diphosphate d-Rhamnose and Guanosine Diphosphate d-Talomethylose from Guanosine Diphosphate α-d-Mannose

Journal of Biological Chemistry, 1964
openaire   +2 more sources

New biosensors and transgenic mice for multiplex cGMP imaging

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a versatile second messenger that is important for human (patho‐)physiology and pharmacotherapy. Live‐cell imaging of cGMP with biosensors allows to elucidate its spatiotemporal dynamics in real time under close‐to‐native conditions. However, to monitor two separate cGMP pools or cGMP/cAMP
Markus Wolters, Martin Thunemann, Barbara Birk, Susanne Feil, Viacheslav O. Nikolaev, Moritz Lehners, Robert Feil   +6 more
wiley   +1 more source