Results 291 to 300 of about 266,483 (401)

Vasoreactivity as a Measure of Kidney Viability During Ex Vivo Normothermic Machine Perfusion

Artificial Organs, EarlyView.
This study aimed to investigate the influence of warm ischemic injury on renal vascular responsiveness to vasoactive drugs during normothermic machine perfusion (NMP). We found that the vascular responses to dopamine and norepinephrine could be used as objective indicators to assess kidney viability during NMP.
Isa M. van Tricht, Baran Ogurlu, Silke S. M. Wolfswinkel, Henri G. D. Leuvenink, Cyril Moers   +4 more
wiley   +1 more source

Genome Analysis and In Vitro Assay of Probiotic Properties of <i>Bacillus paranthracis</i> YC03 with Urate-Lowering Potential. [PDF]

Microorganisms
Cao X, Zhang Y, Xu Q, Yan H.
europepmc   +1 more source

IMPDH inhibition induces DNA replication stress and ATR sensitivity in Merkel cell carcinoma. [PDF]

iScience
Schnabel JL, Frost TC, Wang AC, Ananthapadmanabhan V, Gurram S, Soroko KM, Gokhale PC, DeCaprio JA.   +7 more
europepmc   +1 more source

Targeting acetylated high mobility group box 1 protein (HMGB1) and toll‐like receptor (TLR4) interaction to alleviate hypertension and neuroinflammation in fructose‐fed rats

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Our previous study reported that fructose intake increased systemic blood pressure and reduced nitric oxide (NO) in the nucleus tractus solitarius (NTS) due to oxidative stress and neuroinflammation. However, it remains unclear how reactive oxygen species (ROS) reduce NO and how this process impacts neuroinflammation in ...
Yu‐Te Lin, Chiu‐Yi Ho, Gwo‐Ching Sun, Tzyy‐Yue Wong, Michael Hsiao, Ching‐Jiunn Tseng, Pei‐Wen Cheng   +6 more
wiley   +1 more source

Comparison of the total and individual purine content of commercial maintenance dog foods and therapeutic dog foods that may be prescribed to prevent urate urolithiasis. [PDF]

BMC Vet Res
Ishii CS, Scott KC, Abrahan C, Harmon TA, Colee JC, Queau Y, Biourge V, Garrett TJ, Hill RC.   +8 more
europepmc   +1 more source

Medium components essential for guanosine production in Bacillus subtilis MG-1.

, 1979
Hiroshi Matsui, Katsuaki Sato, Hitoshi Enei, Hiroshiro Shibai, Yoshio Hirose   +4 more
openalex   +2 more sources

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

Guanosine 3':5'-monophosphate-dependent protein kinase from silkworm, properties of a catalytic fragment obtained by limited proteolysis.

, 1976
Masatoshi Inoue, Akira Kishimoto, Yoshimi Takai, Yasutomi Nishizuka   +3 more
openalex   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

How to recover from a bad start: adaptation of HIV-1 transcription start site mutants during serial passaging in culture. [PDF]

J Virol
Nikolaitchik OA, Chameettachal A, Islam S, Cheng Z, Delviks-Frankenberry K, Keele BF, Pathak VK, Hu W-S.   +7 more
europepmc   +1 more source