Results 291 to 300 of about 236,112 (356)

Pyruvate kinase directly generates GTP in glycolysis, supporting growth and contributing to guanosine toxicity. [PDF]

mBio
She F, Liu K, Anderson BW, Pisithkul T, Li Y, Fung DK, McCue T, Mulhern W, Amador-Noguez D, Wang JD.   +9 more
europepmc   +1 more source

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

Pediococcus acidilactici GR-5 alleviates hyperuricemia by degrading purine nucleosides and improving gut microbiota metabolism. [PDF]

NPJ Sci Food
Ji J, An ZY, Khan A, Peng L, Kulshreshtha S, Salama ES, Yun H, Liu P, Jin WL, Li X.   +9 more
europepmc   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

The Scattering Effect-Based Smartphone-Assisted Colorimetric Sensing for Alkaline Phosphatase Detection. [PDF]

Biosensors (Basel)
Zhang H.
europepmc   +1 more source

Differential segment‐specific signalling pathways for guanylate cyclase C‐activated anion secretion in murine ileocolon

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Guanylate cyclase‐C (GC‐C) is the receptor for endogenous (uro)guanylin peptides, bacterial toxins and pharmacological analogues. Receptor activation leads to intestinal fluid loss, but also activates an antiproliferative pathway and is a promising target in colorectal cancer therapy.
Renjie Xiu, Johannes Reiner, Franz Hofmann, Azam Salari, Ursula Seidler   +4 more
wiley   +1 more source

Insights into the Mycosphere Fungal Community and Its Association with Nucleoside Accumulation in <i>Ophiocordyceps sinensis</i>. [PDF]

J Fungi (Basel)
Zhang J, Zhang W, Wu X, Fu W, Yang C, Long N.   +5 more
europepmc   +1 more source

Genome Analysis and In Vitro Assay of Probiotic Properties of <i>Bacillus paranthracis</i> YC03 with Urate-Lowering Potential. [PDF]

Microorganisms
Cao X, Zhang Y, Xu Q, Yan H.
europepmc   +1 more source

Zhenyuan, a kidney- and spleen-tonifying Chinese medicine compound granule, improves erectile dysfunction and fatigue in orchiectomized rats. [PDF]

Transl Androl Urol
Yang RY, Wu CW, Gan LZ, Wu TR, Hu YJ.
europepmc   +1 more source