Results 301 to 310 of about 225,684 (400)

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Crosslinking pathways, dynamics, and kinetics between guanosine and lysine following one- versus two-electron oxidation of guanosine. [PDF]

Nucleic Acids Res
Moe MM, Benny J, Lee V, Tsai M, Liu J.
europepmc   +1 more source

Glutaminase‐1 Mediated Glutaminolysis to Glutathione Synthesis Maintains Redox Homeostasis and Modulates Ferroptosis Sensitivity in Cancer Cells

Cell Proliferation, EarlyView.
GLS1‐mediated glutaminolysis supports GSH synthesis in cancer cells. GLS1 KO increases ROS, downregulates GPX4, and upregulates GPX1, making cells more sensitive to ferroptosis. Combining GLS1 or GPX1 inhibitors with a GPX4 inhibitor synergistically suppresses cancer growth.
Changsen Bai, Jialei Hua, Donghua Meng, Yue Xu, Benfu Zhong, Miao Liu, Zhaosong Wang, Wei Zhou, Liming Liu, Hailong Wang, Yang Liu, Lifang Li, Xiuju Chen, Yueguo Li   +13 more
wiley   +1 more source

Structural basis for sensitivity and acquired resistance of fungal cap guanine-N7 methyltransferases to the antifungal antibiotic sinefungin. [PDF]

Nucleic Acids Res
Nilson DJ, Schwer B, Almo SC, Shuman S, Ghosh A.   +4 more
europepmc   +1 more source

Mycophenolic acid treatment drives the emergence of novel SARS-CoV-2 variants. [PDF]

Proc Natl Acad Sci U S A
Meister TL, Nocke MK, Heinen N, Burkard TL, Brüggemann Y, Westhoven S, Trüeb B, Ebert N, Thomann L, Lubieniecki KP, Lubieniecka JM, Döring K, Herrmann M, Haid S, Pietschmann T, Wiegmann B, Tao R, Pfefferle S, Addo MM, Thiel V, Drexler I, Babel N, Phuc Nguyen H, Brown RJP, Todt D, Steinmann E, Pfaender S.   +26 more
europepmc   +1 more source

OXPHOS complex deficiency in congenital myopathy: A systematic review

European Journal of Clinical Investigation, EarlyView.
This systematic review assessed oxidative phosphorylation (OXPHOS) complex dysfunction in genetically confirmed congenital myopathies (CM). Among 5841 studies screened, 23 publications, comprising 45 CM cases, met the inclusion criteria. OXPHOS dysfunction was identified in 78% of cases, particularly where enzymology was performed, with RYR1 most ...
Megan J. du Preez, Maryke Schoonen, Monray E. Williams, Michelle Bisschoff, Francois H. van der Westhuizen   +4 more
wiley   +1 more source

Guanosine-Based Supramolecular Particles for Enhanced Drug and Gene Delivery in Cell Culture. [PDF]

ACS Appl Bio Mater
Negrón LM, Vázquez-Rosa E, Belfleur L, Díaz TL, Madera-Soto B, Vega IE, Rivera JM.   +6 more
europepmc   +1 more source

Medial septum parvalbumin‐expressing inhibitory neurons are impaired in a mouse model of Dravet syndrome

Epilepsia, EarlyView.
Abstract Objective Dravet syndrome (DS) is a severe neurodevelopmental disorder caused by pathogenic variants in the SCN1A gene, which encodes the voltage‐gated sodium channel Nav1.1 α subunit. Experiments in animal models of DS—including the haploinsufficient Scn1a+/− mouse—have identified impaired excitability of interneurons in the hippocampus and ...
Limei Zhu, Yiannos Demetriou, Joseph Barden, Juan Disla, Meiling Zhao, Joanna Mattis   +5 more
wiley   +1 more source

Discovery of reversing enzymes for RNA ADP-ribosylation reveals a possible defence module against toxic attack. [PDF]

Nucleic Acids Res
Lu Y, Schuller M, Bullen NP, Mikolcevic P, Zonjic I, Raggiaschi R, Mikoc A, Whitney JC, Ahel I.   +8 more
europepmc   +1 more source

Conserved function of a RasGEF‐mediated pathway in the metabolic compensation of the circadian clock

The FEBS Journal, EarlyView.
Metabolic compensation of the circadian clock is essential for stabilizing the period of endogenous timekeeping in environments with significant nutrient fluctuations. In this study, we demonstrate that RasGEF (SOS1)‐mediated signaling, which is influenced by metabolic conditions, supports the robust function of the circadian clock under low glucose ...
Orsolya Sárkány, Anita Szőke, Aladár Pettkó‐Szandtner, Eszter Éva Kálmán, Michael Brunner, Norbert Gyöngyösi, Krisztina Káldi   +6 more
wiley   +1 more source