Results 311 to 320 of about 201,939 (380)

Identification of GDP as a small inhibitory molecule in HepG2 cells by non‑targeted metabolomics analysis. [PDF]

Oncol Lett
Peng Z, Xu S, Wang H, Huang Y, Liu S, Jiao Z, Lin M, Zhu P, Chen Y, Shi Y, Wang Y, Li Y, Yuan W, Wu X, Jiang Z, Li F, Fan X.   +16 more
europepmc   +1 more source

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani, Haibo Ni, Jeffrey J Saucerman, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +5 more
wiley   +1 more source

Stachydrine from Natural Foods Alleviates Hyperuricemia by Modulating Renal Urate Transporters and Suppressing Mitochondrial Oxidative Stress. [PDF]

Foods
Guo J, Jia J, Wang A, Gu Y, Xia X.
europepmc   +1 more source

Understanding the development of bacterial colony: Physiology, new technology, and modeling

Quantitative Biology, Volume 13, Issue 4, December 2025.
Abstract Bacterial colonies, as dynamic ecosystems, display intricate behaviors and organizational structures that profoundly influence their survival and functionality. These communities engage in physiological and social interactions, resulting in remarkable spatial heterogeneity.
Jingwen Zhu, Pan Chu, Xiongfei Fu
wiley   +1 more source

Purine Chemistry in the Early RNA World at the Origins of Life: From RNA and Nucleobases Lesions to Current Key Metabolic Routes. [PDF]

Chembiochem
Décout JL, Maurel MC.
europepmc   +1 more source

Safety, Tolerability, Efficacy, Pharmacokinetics, and Pharmacodynamics of Afimetoran, a Toll‐Like Receptor 7 and 8 Inhibitor, in Patients With Cutaneous Lupus Erythematosus: A Phase 1b Randomized, Double‐Blind, Placebo‐Controlled Study

ACR Open Rheumatology, Volume 7, Issue 7, July 2025.
Objective There is an unmet need for safe and effective oral treatments for cutaneous lupus erythematosus (CLE). Afimetoran is an investigational, first‐in‐class, orally bioavailable, selective small molecule inhibitor of Toll‐like receptors (TLRs) 7 and 8.
Fareeda Hosein, Stanislav Ignatenko, Kristina D. Chadwick, Lin Zhu, Frédéric Baribaud, Jasmine Saini, Thanh Bach, Urvi Aras, WanYing Zhang, Hazem Karabeber, Michelle Dawes, Melanie Harrison, Leonidas N. Carayannopoulos, Gopal Krishna   +13 more
wiley   +1 more source

Phosphorylation of nucleosides by P-N bond species generated from prebiotic reduced phosphorus sources. [PDF]

Commun Chem
Gull M, Cruz HA, Krishnamurthy R, Pasek MA.   +3 more
europepmc   +1 more source

Genetic Inactivation of the Serotonin Transporter Dysregulates Expression of Neurotransmission Genes and Genome‐Wide DNA Methylation Levels in the Medial Prefrontal Cortex of Male Rats During Postnatal Development

Developmental Neurobiology, Volume 85, Issue 3, July 2025.
ABSTRACT Reduced expression of the serotonin transporter (5‐hydroxytryptamine transporter, 5‐HTT) in early life has been associated with a delay in postnatal brain development and endophenotypes of a variety of neuropsychiatric and neurodevelopmental disorders in adolescence and adulthood.
Yvet Kroeze, Martin Oti, Roel H. M. Cooijmans, Ellen van Beusekom, Leonie I. Kroeze, Anthonieke Middelman, Hans van Bokhoven, Sharon M. Kolk, Judith R. Homberg, Huiqing Zhou   +9 more
wiley   +1 more source

Peripheral Antinociception Induced by Carvacrol in the Formalin Test Involves the Opioid Receptor-NO-cGMP-K⁺ Channel Pathway. [PDF]

Metabolites
Ortiz MI, Cariño-Cortés R, Fernández-Martínez E, Muñoz-Pérez VM, Castañeda-Hernández G, González-García MP.   +5 more
europepmc   +1 more source