Results 1 to 10 of about 52,026 (236)

Cyclic Guanosine Monophosphate–Adenosine Monophosphate Synthase (cGAS), a Multifaceted Platform of Intracellular DNA Sensing [PDF]

Frontiers in Immunology, 2021
Innate immune pathways are the first line of cellular defense against pathogen infections ranging from bacteria to Metazoa. These pathways are activated following the recognition of pathogen associated molecular patterns (PAMPs) by membrane and cytosolic
Eloi R. Verrier, Christelle Langevin
doaj   +2 more sources

Regulation of Biofilm Exopolysaccharide Production by Cyclic Di-Guanosine Monophosphate [PDF]

Frontiers in Microbiology, 2021
Many bacterial species in nature possess the ability to transition into a sessile lifestyle and aggregate into cohesive colonies, known as biofilms.
Myles B. Poulin, Laura L. Kuperman
doaj   +2 more sources

U-shaped association between plasma cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) levels and myocardial infarction [PDF]

BMC Cardiovascular Disorders
Background The cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes (cGAS-STING) signaling pathway is closely associated with myocardial infarction (MI).
Quan Zhang, Huiqing Ding, Zhongling Dai, Rukai Yang, Shenghua Zhou, Shi Tai   +5 more
doaj   +2 more sources

Optogenetic manipulation of cyclic guanosine monophosphate to probe phosphodiesterase activities in megakaryocytes [PDF]

Open Biology, 2022
Cyclic guanosine monophosphate (cGMP) signalling plays a fundamental role in many cell types, including platelets. cGMP has been implicated in platelet formation, but mechanistic detail about its spatio-temporal regulation in megakaryocytes (MKs) is ...
Yujing Zhang, Pascal Benz, Daniel Stehle, Shang Yang, Hendrikje Kurz, Susanne Feil, Georg Nagel, Robert Feil, Shiqiang Gao, Markus Bender   +9 more
doaj   +2 more sources

A Homogeneous Bioluminescent System to Monitor Cyclic Guanosine Monophosphate. [PDF]

ACS Pharmacol Transl Sci, 2023
Murray NH, Larsen MA, Hsiao K, Mikheil D, Vidugiris G, Wang H, Goueli SA.   +6 more
europepmc   +2 more sources

The cyclic guanosine monophosphate synthase-stimulator of interferon genes pathway as a potential target for tumor immunotherapy [PDF]

Frontiers in Immunology, 2023
Cyclic guanosine monophosphate–adenosine monophosphate (cGAMP) synthase (cGAS) detects infections or tissue damage by binding to microbial or self-DNA in the cytoplasm. Upon binding DNA, cGAS produces cGAMP that binds to and activates the adaptor protein
Rui Chen, Mingxia Liu, Quanhong Jiang, Xiangbo Meng, Junmin Wei   +4 more
doaj   +2 more sources

Polygonatum sibiricum (Huang Jing) polysaccharide reduces diabetic cardiomyopathy through increasing cyclic guanosine monophosphate‐protein kinase G signaling in diabetic mice [PDF]

Journal of Diabetes Investigation
Aims/Introduction Diabetic cardiomyopathy (DCM) is a prevalent condition among individuals with diabetes, and is associated with a high mortality rate.
Shengping Lei, Xin Lu, Lei Yan, Tian Liu, Yan Niu, Jun Yu   +5 more
doaj   +2 more sources

Associations Between the Cyclic Guanosine Monophosphate Pathway and Cardiovascular Risk Factors: MESA [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background cGMP mediates numerous cardioprotective functions and is a potential therapeutic target for cardiovascular disease. Preclinical studies suggest that plasma cGMP is reflective of natriuretic peptide stimulation.
Wendy Ying, Di Zhao, Pamela Ouyang, Vinita Subramanya, Dhananjay Vaidya, Chiadi E. Ndumele, Eliseo Guallar, Kavita Sharma, Sanjiv J. Shah, David A. Kass, Ron C. Hoogeveen, Joao A. Lima, Susan R. Heckbert, Christopher R. deFilippi, Wendy S. Post, Erin D. Michos   +15 more
doaj   +2 more sources

Urinary cGMP (Cyclic Guanosine Monophosphate)/BNP (B-Type Natriuretic Peptide) Ratio, Sacubitril/Valsartan, and Outcomes in Heart Failure With Reduced Ejection Fraction: An Analysis of the PARADIGM-HF Trial. [PDF]

Circ Heart Fail, 2023
Butt JH, Ibrahim W, Dewan P, Desai AS, Køber L, Prescott MF, Lefkowitz MP, Rouleau JL, Solomon SD, Zile MR, Packer M, Jhund PS, McMurray JJV.   +12 more
europepmc   +3 more sources

Spectrofluorimetric determination of cyclic guanosine monophosphate in human nasal secretions: evaluating levels in healthy individuals and patients with olfactory dysfunction. [PDF]

BMC Chem
Abdelazim MH, Alsenani F, Alharbi A, Baali FH, Baali AH, Abduljabbar MH, Alnemari RM, Algarni MA.   +7 more
europepmc   +3 more sources