Cyclic Guanosine Monophosphate–Adenosine Monophosphate Synthase (cGAS), a Multifaceted Platform of Intracellular DNA Sensing [PDF]
Frontiers in Immunology, 2021 Innate immune pathways are the first line of cellular defense against pathogen infections ranging from bacteria to Metazoa. These pathways are activated following the recognition of pathogen associated molecular patterns (PAMPs) by membrane and cytosolic
Eloi R. Verrier, Christelle Langevin
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Regulation of Biofilm Exopolysaccharide Production by Cyclic Di-Guanosine Monophosphate [PDF]
Frontiers in Microbiology, 2021 Many bacterial species in nature possess the ability to transition into a sessile lifestyle and aggregate into cohesive colonies, known as biofilms.
Myles B. Poulin, Laura L. Kuperman
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U-shaped association between plasma cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) levels and myocardial infarction [PDF]
BMC Cardiovascular DisordersBackground The cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes (cGAS-STING) signaling pathway is closely associated with myocardial infarction (MI).
Quan Zhang +5 more
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Optogenetic manipulation of cyclic guanosine monophosphate to probe phosphodiesterase activities in megakaryocytes [PDF]
Open Biology, 2022 Cyclic guanosine monophosphate (cGMP) signalling plays a fundamental role in many cell types, including platelets. cGMP has been implicated in platelet formation, but mechanistic detail about its spatio-temporal regulation in megakaryocytes (MKs) is ...
Yujing Zhang +9 more
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The cyclic guanosine monophosphate synthase-stimulator of interferon genes pathway as a potential target for tumor immunotherapy [PDF]
Frontiers in Immunology, 2023 Cyclic guanosine monophosphate–adenosine monophosphate (cGAMP) synthase (cGAS) detects infections or tissue damage by binding to microbial or self-DNA in the cytoplasm. Upon binding DNA, cGAS produces cGAMP that binds to and activates the adaptor protein
Rui Chen +4 more
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Polygonatum sibiricum (Huang Jing) polysaccharide reduces diabetic cardiomyopathy through increasing cyclic guanosine monophosphate‐protein kinase G signaling in diabetic mice [PDF]
Journal of Diabetes InvestigationAims/Introduction Diabetic cardiomyopathy (DCM) is a prevalent condition among individuals with diabetes, and is associated with a high mortality rate.
Shengping Lei +5 more
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Associations Between the Cyclic Guanosine Monophosphate Pathway and Cardiovascular Risk Factors: MESA [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019 Background cGMP mediates numerous cardioprotective functions and is a potential therapeutic target for cardiovascular disease. Preclinical studies suggest that plasma cGMP is reflective of natriuretic peptide stimulation.
Wendy Ying +15 more
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Current Modulation of Guanylate Cyclase Pathway Activity—Mechanism and Clinical Implications
Molecules, 2021 For years, guanylate cyclase seemed to be homogenic and tissue nonspecific enzyme; however, in the last few years, in light of preclinical and clinical trials, it became an interesting target for pharmacological intervention.
Grzegorz Grześk, Alicja Nowaczyk
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Nature Communications, 2021 Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) is normally induced by innate immunity sensing for protection from pathogens. Here the authors show that cGAMP is also upstream of DNA damage signaling by activating ATM-CHK2-mediated repair ...
Daipayan Banerjee +13 more
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Development of a red fluorescent protein-based cGMP indicator applicable for live-cell imaging
Communications Biology, 2022 A red fluorescent protein-based indicator of cyclic guanosine 3′, 5′-monophosphate (cGMP) allows for multi-colour imaging and optogenetic applications while monitoring cGMP activity in cells.
Mai Takizawa +7 more
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