Results 101 to 110 of about 144,757 (372)

Effect of cyclic 
guanosine‐monophosphate on porcine retinal vasomotion [PDF]

Acta Ophthalmologica Scandinavica, 2006
Abstract.Purpose:  Vasomotion refers to periodic oscillations in vascular tone that ensure the intermittent supply of blood to adjacent microvascular units. Previous evidence from vessels outside the eye suggests that cyclic guanosine‐monophosphate (cGMP) is involved in the regulation of vasomotion, but it is unknown whether this compound has an ...
Toke Bek, Christian Aalkjaer, Anders Hessellund   +2 more
openaire   +3 more sources

Leucine‐Rich Repeat‐Containing G Protein‐Coupled Receptor 6 Ameliorates Pressure Overload‐Induced Cardiac Hypertrophy by Regulating Cardiomyocyte Metabolic Reprogramming

Advanced Science, EarlyView.
LGR6 overexpression ameliorates cardiac hypertrophy by regulating metabolic reprogramming through USP4‐PPARα pathway. Abstract Metabolic reprogramming is a pivotal mechanism in the pathogenesis of pathological cardiac hypertrophy. Leucine‐rich repeat‐containing G protein‐coupled receptor 6 (Lgr6) has emerged as a significant player in cardiovascular ...
Mengmeng Zhao, Jianfang Liu, Shanshan Peng, Zihui Zheng, Siqi Liu, Jun Wan, Yao Xu, Menglong Wang   +7 more
wiley   +1 more source

Mirodenafil ameliorates skin fibrosis in bleomycin-induced mouse model of systemic sclerosis

Animal Cells and Systems, 2021
Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by fibrosis of the skin and internal organs. Despite the recent advances in the pathogenesis and treatment of SSc, effective therapies for fibrosis caused by SSc have not yet been ...
Jong Seong Roh, Hoim Jeong, Beomgu Lee, Byung Wook Song, Seung Jin Han, Dong Hyun Sohn, Seung-Geun Lee   +6 more
doaj   +1 more source

Selective phosphodiesterase-5 (PDE-5) inhibitor vardenafil ameliorates renal damage in type 1 diabetic rats by restoring cyclic 3',5' guanosine monophosphate (cGMP) level in podocytes.

Nephrology, Dialysis and Transplantation, 2013
BACKGROUND Diabetic nephropathy (DN) is characterized by podocyte damage and increased phosphodiesterase-5 (PDE-5) activity-exacerbating nitric oxide (NO)-cyclic 3',5' guanosine monophosphate (cGMP) pathway dysfunction.
Lilla Fang, T. Radovits, G. Szabó, M. Mózes, L. Rosivall, G. Kökény   +5 more
semanticscholar   +1 more source

Nucleotides function as endogenous chemical sensors for oxidative stress signaling [PDF]

, 2010
Oxidized and nitrated nucleotides including 8-oxogunanine and 8-nitroguanine derivatives such as 8-nitroguanosine 3',5'-cyclic monophosphate were generated by reactive nitrogen oxides and reactive oxygen species in cultured cells and in tissues.
Akaike, Takaaki, Ihara, Hideshi, Nakabeppu, Yusaku, Sawa, Tomohiro   +3 more
core   +2 more sources

Nitric Oxide-cGMP Signaling in Hypertension:Current and Future Options for Pharmacotherapy [PDF]

, 2020
For the treatment of systemic hypertension, pharmacological intervention in nitric oxide-cyclic guanosine monophosphate signaling is a well-explored but unexploited option.
Ataei Ataabadi, Ehsan, Danser, A. H. Jan, Golshiri, Keivan, Juttner, Annika, Krenning, Guido, Roks, Anton J. M.   +5 more
core   +1 more source

Smart Organic–Inorganic Copolymer Nanoparticles Distinguish Between Microglia and Cancer Cells for Synergistic Immunotherapy in Glioma

Advanced Science, EarlyView.
The tumor microenvironment‐responsive nanoagonists are developed using an organic–inorganic copolymer composed of the polymer (PC6AB) and manganous phosphate ionic oligomers (MnP). PC6AB with membranolytic activity selectively interacts with tumor cell membranes to induce immunogenic cell death, while MnP activates the STING pathway in immune cells ...
Shiming Zhang, Kun Shang, Lidong Gong, Qian Xie, Jianfei Sun, Meng Xu, Xunbin Wei, Zhaoheng Xie, Xinyu Liu, Hao Tang, Zhengren Xu, Wei Wang, Haihua Xiao, Zhiqiang Lin, Hongbin Han   +14 more
wiley   +1 more source

Evolution of the bacterial nucleosidase PpnN and its relation to the stringent response

Microbial Cell, 2019
In our recent publication (Zhang et al., 2019), we demonstrate an interesting mode of regulation of purine metabolism unique to Proteobacteria. In this microreview, we would like to reflect on the ideas put forward, with special focus on protein domain ...
René Lysdal Bærentsen, Ditlev Egeskov Brodersen, Yong Everett Zhang   +2 more
doaj   +1 more source

A Novel Gene vp0610 Negatively Regulates Biofilm Formation in Vibrio parahaemolyticus

Frontiers in Microbiology, 2021
Vibrio parahaemolyticus is an important foodborne pathogen and its biofilm formation ability facilitates its colonization and persistence in foods by protecting it from stresses including environmental variation and antibiotic exposure. Several important
Fufeng Jiang, Fufeng Jiang, Tao Lei, Zhi Wang, Min He, Jumei Zhang, Juan Wang, Haiyan Zeng, Moutong Chen, Liang Xue, Qinghua Ye, Rui Pang, Shi Wu, Qihui Gu, Yu Ding, Qingping Wu   +15 more
doaj   +1 more source

Disrupted pulmonary artery cyclic guanosine monophosphate signaling in mice with hyperoxia-induced pulmonary hypertension.

American Journal of Respiratory Cell and Molecular Biology, 2013
Pulmonary hypertension (PH) occurs in 25 to 35% of premature infants with significant bronchopulmonary dysplasia (BPD). Neonatal mice exposed to 14 days of hyperoxia develop BPD-like lung injury and PH.
Keng Jin Lee, S. Berkelhamer, Gina A. Kim, Joann M. Taylor, K. O’Shea, R. Steinhorn, K. Farrow   +6 more
semanticscholar   +1 more source