Receptor‐Dependent and ‐Independent Effects of Hemin on Platelet Plasma Membrane Disintegration
Microhemorrhages lead to the release of erythrocytes, which are then degraded and lysed. These hemolyses result in the liberation of free iron‐containing hemin. Hemin induces platelet activation and ferroptosis. Inhibition of GPVI/CLEC‐2 receptor‐mediated ITAM‐signaling inhibits hemin‐induced platelet activation (low hemin concentrations). Deferoxamine,
Zoi Laspa +5 more
wiley +1 more source
Ajuga bracteosa Exerts Antihypertensive Activity in l-NAME-Induced Hypertension Possibly through Modulation of Oxidative Stress, Proinflammatory Cytokines, and the Nitric Oxide/Cyclic Guanosine Monophosphate Pathway. [PDF]
Shaukat B +7 more
europepmc +1 more source
Soy isoflavone yeast fermented extract inhibits contraction of rat ileal smooth muscle via opening of K<sup>+</sup> channels and activation of intracellular cyclic adenosine monophosphate- and cyclic guanosine monophosphate-related pathways. [PDF]
Yamazaki S +4 more
europepmc +1 more source
Rubus occidentalis and Ellagic Acid Affect the Contractility of Penile Corpus Cavernosum Smooth Muscle through the Nitric Oxide-Cyclic Guanosine Monophosphate and Cyclic Adenosine 3',5'-Monophosphate Signaling Pathway. [PDF]
Karna KK +4 more
europepmc +1 more source
Bidirectional regulation of the cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon gene pathway and its impact on hepatocellular carcinoma. [PDF]
Nie AY +6 more
europepmc +1 more source
Guanosine monophosphate synthase upregulation mediates cervical cancer progression by inhibiting the apoptosis of cervical cancer cells via the Stat3/P53 pathway. [PDF]
Wang J +6 more
europepmc +1 more source
Hydration water drives the self-assembly of guanosine monophosphate. [PDF]
Tao YH +8 more
europepmc +1 more source

