Results 71 to 80 of about 144,757 (372)

Conformation, hydrogen bonding and aggregate formation of guanosine 5′-monophosphate and guanosine in dimethylsulfoxide [PDF]

Nucleic Acids Research, 1994
The tetrabutylammonium salt of guanosine 5'-monophosphate (5'-GMP) dissolves in DMSO-d6 forming aggregated species which exhibit some properties of reverse micelles. 1H NOESY experiments show that the 5'-GMP adopts the syn conformation about the glycosidic bond.
Judith A. Walmsely, Leoncio A. Garza, William R. Winchester, R. Ted West   +3 more
openaire   +2 more sources

Cyclic 3'-5' guanosine monophosphate-dependent activity in Leishmania amazonensis

Memorias do Instituto Oswaldo Cruz, 2003
Although there are some data concerning the nitric oxide and the cyclic 3'-5'guanosine monophosphate (cGMP) signaling pathway in trypanosomatids, there is no report about the cGMP-dependent enzymatic activity identification.
LF Géigel, LL Leon
doaj   +1 more source

Cyclic guanosine monophosphate does not inhibit gonadotropin-induced activation of mitogen-activated protein kinase 3/1 in pig cumulus-oocyte complexes

Reproductive Biology and Endocrinology, 2015
BackgroundRecent results indicate a key role for cyclic guanosine monophosphate (cGMP) in the regulation of oocyte meiotic arrest in preovulatory mammalian follicles.
Milan Blaha, L. Němcová, R. Procházka
semanticscholar   +1 more source

Spontaneous assembly of an organic-inorganic nucleic acid Z-DNA double-helix structure [PDF]

, 2017
Herein, we report a hybrid polyoxometalate organic–inorganic compound, Na2[(HGMP)2Mo5O15]⋅7 H2O (1; where GMP=guanosine monophosphate), which spontaneously assembles into a structure with dimensions that are strikingly similar to those of the naturally ...
Albrecht, Arnott, Barnes, Braga, Cafferty, Cairns-Smith, Carraro, Champ, Cooper, Crick, Ellena, Hill, Humphrey, Inoue, Kim, Kulikov, Kwak, Li, Maehigashi, Martins, Murayama, Nordén, Parker, Powner, Rich, Ritson, Soghomonian, Strandberg, Sun, Tang, Van Hecke, Vasconcelos, Voet, Wang, Wong, Yamase, Yu   +36 more
core   +1 more source

Red blood cell endothelial nitric oxide synthase: A major player in regulating cardiovascular health

British Journal of Pharmacology, EarlyView., 2023
Abstract Red blood cells (RBCs) have traditionally been seen as simple carriers of gases and nutrients in the body. One important non‐canonical function of RBCs in the cardiovascular system is the regulation of nitric oxide (NO) metabolism. It has been shown that RBCs can scavenge NO, transport NO metabolites and produce NO in hypoxic conditions ...
Anthea LoBue, Sophia K. Heuser, Marla Lindemann, Junjie Li, Masudur Rahman, Malte Kelm, Johannes Stegbauer, Miriam M. Cortese‐Krott   +7 more
wiley   +1 more source

The role of Phosphodiesterase-1 and its natural product inhibitors in Alzheimer’s disease: A review

Frontiers in Pharmacology, 2022
Phosphodiesterase-1 (PDE1) is a versatile enzyme that has surprisingly received considerable attention as a possible therapeutic target in Alzheimer’s disease (AD) because it maintains the homeostasis of 3ʹ,5ʹ-cyclic adenosine monophosphate (cAMP) and 3ʹ,
Nazir Ahmad, Kaisun Nesa Lesa, Ari Sudarmanto, Nanang Fakhrudin, Nanang Fakhrudin, Zullies Ikawati   +5 more
doaj   +1 more source

On the parabolic-elliptic Keller-Segel system with signal-dependent motilities: a paradigm for global boundedness and steady states [PDF]

, 2020
This paper is concerned with a parabolic-elliptic Keller-Segel system where both diffusive and chemotactic coefficients (motility functions) depend on the chemical signal density. This system was originally proposed by Keller and Segel in \cite{KS-1971-JTB2} to describe the aggregation phase of {\it Dictyostelium discoideum} cells in response to the ...
arxiv   +1 more source

Modelling of Dictyostelium Discoideum Movement in Linear Gradient of Chemoattractant [PDF]

Soft Matter,Vol. 13, pp. 8209-8222 (2017), 2018
Chemotaxis is a ubiquitous biological phenomenon in which cells detect a spatial gradient of chemoattractant, and then move towards the source. Here we present a position-dependent advection-diffusion model that quantitatively describes the statistical features of the chemotactic motion of the social amoeba {\it Dictyostelium discoideum} in a linear ...
arxiv   +1 more source

Natriuretic peptide receptors regulate cytoprotective effects in a human ex vivo 3D/bioreactor model [PDF]

, 2013
© 2013 Peake et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and ...
Achan, P, Bader, DL, Chowdhury, TT, Hobbs, AJ, Moyes, AJ, Peake, N, Ramachandran, M, Salter, DM, Su, N   +8 more
core   +2 more sources

The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson’s disease

Neural Regeneration Research
Interferon regulatory factor 7 plays a crucial role in the innate immune response. However, whether interferon regulatory factor 7-mediated signaling contributes to Parkinson’s disease remains unknown.
Shengyang Zhou, Ting Li, Wei Zhang, Jian Wu, Hui Hong, Wei Quan, Xinyu Qiao, Chun Cui, Chenmeng Qiao, Weijiang Zhao, Yanqin Shen   +10 more
doaj   +1 more source