Results 81 to 90 of about 144,757 (372)

Imaging of PDE2- and PDE3-Mediated cGMP-to-cAMP Cross-Talk in Cardiomyocytes

Journal of Cardiovascular Development and Disease, 2018
Cyclic nucleotides 3′,5′-cyclic adenosine monophosphate (cAMP) and 3′,5′-cyclic guanosine monophosphate (cGMP) are important second messengers that regulate cardiovascular function and disease by acting in discrete subcellular microdomains.
Nikoleta Pavlaki, Viacheslav O. Nikolaev
doaj   +1 more source

Piezo1 channels enhance anabolic signaling activation induced by electrical stimulation of cultured myotubes

FEBS Open Bio, EarlyView.
By using an electrical pulse stimulation (EPS)‐based in vitro exercise model and chemical activation/inhibition of mechanosensitive Piezo1 channels, we explored changes in protein synthetic response in cultured C2C12 myotubes. Our data showed that application of Piezo1 activator (Yoda1) during EPS significantly enhances the rate of protein synthesis in
Natalia A. Vilchinskaya, Ksenia V. Sergeeva, Boris S. Shenkman, Timur M. Mirzoev   +3 more
wiley   +1 more source

Discovery of inhibitors of Leishmania β-1,2-mannosyltransferases using a click-chemistry-derived guanosine monophosphate library. [PDF]

PLoS ONE, 2012
Leishmania spp. are a medically important group of protozoan parasites that synthesize a novel intracellular carbohydrate reserve polymer termed mannogen.
Phillip van der Peet, Julie E Ralton, Malcolm J McConville, Spencer J Williams   +3 more
doaj   +1 more source

Determination of association constants between 5 '-guanosine monophosphate gel and aromatic compounds by capillary electrophoresis [PDF]

, 2013
Hydro gel formed by 5'-guanosine monophosphate (GMP) in the presence of a potassium ion is expected to exhibit interesting selectivity in capillary electrophoretic separations.
Alberty, Barker, Case, Chen, Chinai, Cohen, Cohen, Cohen, Davis, Dobashi, Dong, Dong, Dowling, Gozel, Heiger, Hjertén, Honda, Jorgenson, Kaori Yamaguchi, Khaledi, Kuhn, Kuhn, Mikkers, Muijselaar, Nobuyuki Takeyasu, Rundlett, Sepulveda, Smith, Takashi Kaneta, Terabe, Ueda, Widhalm, Šponer   +32 more
core   +1 more source

Gasotransmitters in Modern Medicine: Promises and Challenges in the Use of Porous Crystalline Carriers

Advanced Healthcare Materials, EarlyView.
This perspective provides an overview of the growing interest in utilizing various gasotransmitters—small gaseous signaling molecules namely nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S)—for several therapeutic applications, with emphasis on the potential use of porous materials as carriers to provide safe and controlled local ...
Rosana V. Pinto, Moisés L. Pinto, Christian Serre   +2 more
wiley   +1 more source

An Information Theoretical Analysis of Kinase Activated Phosphorylation Dephosphorylation Cycle [PDF]

IEEE Transactions on NanoBioscience, Volume 11, Issue 3, pp. 289 - 295 (2012), 2011
Signal transduction, the information processing mechanism in biological cells, is carried out by a network of biochemical reactions. The dynamics of driven biochemical reactions can be studied in terms of nonequilibrium statistical physics. Such systems may also be studied in terms of Shannon's information theory.
arxiv   +1 more source

Chemotherapy‐Mediated Induction of PD‐L1 via SEI1 Facilitates Myeloma Immune Evasion

Advanced Science, EarlyView.
Chemotherapy induces DNA damage, activating cyclic guanosine monophosphate (GMP)‐adenosine monophosphate (AMP) synthase (cGAS)/stimulator of interferon genes (STING), which phosphorylates interferon regulatory factor 7 (IRF7) to drive SERTA‐containing domain 1 (SEI1) transcription.
Rui Chen, Zongwei Li, Zhihong Fang, Zou Li, Daoyan Yang, Yuan Li, Shurong Liu, Zhiqiang Liu, Rui Liu, Huan Liu   +9 more
wiley   +1 more source

Novel Characteristics of Trypanosoma brucei Guanosine 5'-monophosphate Reductase Distinct from Host Animals. [PDF]

PLoS Neglected Tropical Diseases, 2016
The metabolic pathway of purine nucleotides in parasitic protozoa is a potent drug target for treatment of parasitemia. Guanosine 5'-monophosphate reductase (GMPR), which catalyzes the deamination of guanosine 5'-monophosphate (GMP) to inosine 5 ...
Tomoaki Bessho, Tetsuya Okada, Chihiro Kimura, Takahiro Shinohara, Ai Tomiyama, Akira Imamura, Mitsuru Kuwamura, Kazuhiko Nishimura, Ko Fujimori, Satoshi Shuto, Osamu Ishibashi, Bruno Kilunga Kubata, Takashi Inui   +12 more
doaj   +1 more source

The changes of umami substances and influencing factors in preserved egg yolk: pH, endogenous protease, and proteinaceous substance

Frontiers in Nutrition, 2022
The study investigated the changes of nucleotides, succinic acid, and free amino acids amounts in yolk and the causes leading to the changes after pickling to uncover the fundamental umami component of preserved egg yolk.
Binghong Gao, Binghong Gao, Xiaobo Hu, Hui Xue, Ruiling Li, Huilan Liu, Tianfeng Han, Yonggang Tu, Yan Zhao   +8 more
doaj   +1 more source

A thermodynamic paradigm for solution demixing inspired by nuclear transport in living cells [PDF]

Phys. Rev. Lett. 118, 158101 (2017), 2016
Living cells display a remarkable capacity to compartmentalize their functional biochemistry. A particularly fascinating example is the cell nucleus. Exchange of macromolecules between the nucleus and the surrounding cytoplasm does not involve traversing a lipid bilayer membrane.
arxiv   +1 more source