Redirecting Intermediary Metabolism to Counteract Cyanide Poisoning
The FASEB Journal, Volume 39, Issue 12, 30 June 2025.Cyanide is coined “the classic metabolic poison”; however, FDA‐approved cyanide chelators do not counteract cyanide's metabolic damage. Here, we review the mechanisms of cyanide toxicity, with a focus on intermediary metabolism. We present the theory that, within the innate plasticity of the metabolome, there may reside metabolic pathways that can ...
Vik S. Bebarta, Anjali K. Nath
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Cells injected with guanosine 5'-[alpha, beta-methylene]triphosphate, an alpha, beta-nonhydrolyzable analog of GTP, show anomalous patterns of tubulin polymerization affecting cell translocation, intracellular movement, and the organization of Golgi elements. [PDF]
, 1983 J Wehland, Ignacio V. Sandoval
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Ground testing of bioconvective variables such as morphological characterizations and mechanisms which regulate macroscopic patterns [PDF]
Conditions simulating low- and high-gravity, reveal changes in macroscopic pattern formation in selected microorganisms, but whether these structures are gravity dependent is not clear.
Johnson, Adriel D.
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Drug Design, Development and Therapy, 2013 Giovanni M Pitari Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA, USA Abstract: Agonists of the transmembrane intestinal receptor guanylyl cyclase C (GCC) have recently attracted interest as ...
Pitari GM
doaj
The FASEB Journal, Volume 39, Issue 11, 15 June 2025.Proposed change in TNF‐α biogenesis with urbanization in sub‐Saharan Africa. Higher levels of aspartate in the rural population result in a NAD+ rich environment that favors stabilization of the endoplasmic reticulum (ER) membrane and suppressing TNF‐α.
Stephen W. Bickler +6 more
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Modification of guanine nucleotide-regulatory components in brain membranes. II. Relationship of guanosine 5'-triphosphate effects on opiate receptor binding and coupling receptors with adenylate cyclase [PDF]
, 1984 SR Childers, G R Lariviere
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Activation of phospholipase C associated with isolated rabbit platelet membranes by guanosine 5′-[γ-thio]triphosphate and by thrombin in the presence of GTP [PDF]
, 1987 Janet K. Hrbolich +2 more
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Light‐Responsive Mononucleotide Coacervates
Chemistry – A European Journal, Volume 31, Issue 31, June 3, 2025.Light‐responsive mononucleotide coacervates undergo reversible phase transitions via azobenzene photoisomerization. Coacervates with high‐valency azobenzenes remain stable under UV light, while those with low‐valency azobenzenes dissolve, enabling nucleotide release. This minimal system highlights the potential role of light for exploring energy‐driven
Edison Rafael Jimenez Granda +4 more
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