Results 171 to 180 of about 73,799 (301)

Klebsiella pneumoniae contributes to altered cytotoxicity of thiopurines in vitro: Possible implications of biotransformation and bacterial metabolism

British Journal of Pharmacology, Volume 182, Issue 18, Page 4281-4298, September 2025.
Abstract Background and purpose Thiopurines are used in paediatric inflammatory bowel disease (IBD), but some patients do not respond. Because the gut microbiota influences drug efficacy and IBD‐patient microbiota presents increased bacterial abundance, we investigated the impact of candidate Enterobacteriaceae on drug cytotoxicity, metabolism and ...
Martina Franzin, Cristina Lagatolla, Sofia Sindici Forgiarini, Mathias Haag, Sylvia Karin Neef, Manola Comar, Elke Schaeffeler, Barbara Bellich, Matteo Bramuzzo, Giuliana Decorti, Marianna Lucafò, Ute Hofmann, Matthias Schwab, Gabriele Stocco   +13 more
wiley   +1 more source

Desensitization of beta-adrenergic receptors by beta-adrenergic agonists in a cell-free system: resensitization by guanosine 5'-(beta, gamma-imino)triphosphate and other purine nucleotides.

, 1976
Chhabirani Mukherjee, Robert J. Lefkowitz   +1 more
openalex   +1 more source

Thyrotropin-releasing hormone and gonadotropin-releasing hormone receptors activate phospholipase C by coupling to the guanosine triphosphate-binding proteins Gq and G11. [PDF]

, 1992
Kai Hsieh, Thomas F.J. Martin
openalex   +1 more source

PI5P4K inhibitors: promising opportunities and challenges

The FEBS Journal, Volume 292, Issue 17, Page 4446-4476, September 2025.
Developing inhibitors is like climbing a steep, challenging mountain. PI5P4K inhibitors hold significant promise for the treatment of cancer, immune disorders, and neurological diseases. However, the path to success is fraught with hurdles, and researchers are therefore required to apply their expertise to overcome critical “checkpoints.” While some ...
Koh Takeuchi, Lisa Nagase, Shun Kageyama, Hirotaka Kanoh, Masashi Oshima, Aki Ogawa‐Iio, Yoshiki Ikeda, Yuki Fujii, Sei Kondo, Natsuki Osaka, Takeshi Masuda, Tsukasa Ishihara, Yoshikazu Nakamura, Yoshihisa Hirota, Takehiko Sasaki, Toshiya Senda, Atsuo T. Sasaki   +16 more
wiley   +1 more source

ISOLATION OF GUANOSINE DI- AND TRIPHOSPHATES FROM YEAST

Journal of Biological Chemistry, 1956
C. H. Lee Peng, D.R. Sanadi, Padmasini Ayengar, David M. Gibson   +3 more
openaire   +3 more sources

Preparation of Homogeneous Elongation Factor G and Examination of the Mechanism of Guanosine Triphosphate Hydrolysis

, 1974
Michael S. Rohrbach, Mary E. Dempsey, James W. Bodley   +2 more
openalex   +1 more source

Digenesis in Charcot–Marie–Tooth Disease: Impact of Combined Mutations in the MFN2 and GDAP1 Genes

Journal of the Peripheral Nervous System, Volume 30, Issue 3, September 2025.
ABSTRACT Background and Aims Charcot–Marie–Tooth disease (CMT) is a rare hereditary neuropathy that affects peripheral nerves in the upper and lower limbs. To distinguish between the different forms of the disease, electrophysiological criteria are essential.
Endrit Shumeri, Ebrahem Mandorah, Nathalie Martini, Amandine Boyer, Cécile Halbert, Angela Puma, Annabelle Chaussenot, Emilien Delmont, Karine N'guyen, Shahram Attarian, Nathalie Bonello‐Palot   +10 more
wiley   +1 more source

Dexras1/AGS-1, a Steroid Hormone-Induced Guanosine Triphosphate-Binding Protein, Inhibits 3',5'-Cyclic Adenosine Monophosphate-Stimulated Secretion in AtT-20 Corticotroph Cells [PDF]

, 2001
T. E. Graham
openalex   +2 more sources

Initiation Factor 2-Dependent Ribosomal Binding of N -Formylmethionyl-Transfer RNA Without Added Guanosine Triphosphate

, 1972
Rajarshi Mazumder
openalex   +1 more source

RNA elements and their biotechnological applications in plants

New Phytologist, Volume 247, Issue 6, Page 2517-2537, September 2025.
Summary Engineering of plants for improved traits and efficient heterologous protein production can be achieved by modifying or introducing cis‐ or trans‐acting RNA elements. The function of these elements depends not only on their nucleotide sequence but also on their highly dynamic higher order structures.
Filip Lastovka, Hadrien Peyret, George P. Lomonossoff, Betty Y.‐W. Chung   +3 more
wiley   +1 more source