ABSTRACT Background and Aims Gemcitabine‐based treatment is normally used for pancreatic ductal adenocarcinoma (PDAC). Genetic polymorphisms of the Kirsten rat and novel oncogene homologue (KRAS) variant contribute to the survival and prognosis of patients with PDAC. We aimed to reveal a potential gene signature against the background of KRAS mutations
Xinying He +3 more
wiley +1 more source
Group A streptococcus cell-associated pathogenic proteins as revealed by growth in hyaluronic acid enriched media. [PDF]
Ashbaugh +59 more
core +1 more source
Guanosine 5′-3-O-(Thio)triphosphate Stimulates Tyrosine Phosphorylation of p125FAK and Paxillin in Permeabilized Swiss 3T3 Cells [PDF]
Michael J. Seckl +3 more
openalex +1 more source
The Lrs14‐Like AbfR1 Homolog From Metallosphaera sedula Is a Nucleoid‐Organizing Protein
Nucleoid organization in Crenarchaeota involves diverse small DNA‐binding proteins. The Lrs14‐type protein AbfR1 from Metallosphaera sedula binds nonsequence specifically across the genome and induces DNA condensation. These findings suggest a structural role for AbfR1Ms in chromatin architecture, functionally resembling bacterial nucleoid‐associated ...
Veerke De Kock +5 more
wiley +1 more source
Developing inhibitors of the guanosine triphosphate hydrolysis accelerating activity of Regulator of G protein Signaling-14. [PDF]
Agogo-Mawuli PS +7 more
europepmc +1 more source
The Small Guanosine Triphosphate-Binding Protein Rab4 Is Involved in Insulin-Induced GLUT4 Translocation and Actin Filament Rearrangement in 3T3-L1 Cells* [PDF]
Péter Vollenweider +8 more
openalex +1 more source
Abstract Alpha‐synuclein (αS) and tau play important roles in the pathology of Parkinson's disease and Alzheimer's disease, respectively, as well as numerous other neurodegenerative diseases. Both proteins are classified as intrinsically disordered proteins (IDPs), as they have no stable structure that underlies their function in healthy tissue, and ...
Ibrahim G. Saleh +17 more
wiley +1 more source
Production of the Antimicrobial Roseoflavin With Genetically Engineered Corynebacterium glutamicum
Corynebacterium glutamicum was genetically engineered for the production of the riboflavin analog roseoflavin, while minimising its antimicrobial effects. To this end, the genetic machinery from the natural roseoflavin producer Streptomyces davaonensis was evaluated in a riboflavin‐producing C. glutamicum strain.
Luciana Fernandes Brito +4 more
wiley +1 more source
Autosomal Recessive Guanosine Triphosphate Cyclohydrolase I Deficiency: Redefining the Phenotypic Spectrum and Outcomes. [PDF]
Novelli M +11 more
europepmc +1 more source

