Results 201 to 210 of about 83,988 (248)

Aberrant guanosine triphosphate–beta‐tubulin interaction in Alzheimer's disease

Annals of Neurology, 1989
AbstractGuanosine triphosphate (GTP) is an absolute requirement for tubulin polymerization in situ. The nucleotide photoaffinity probe 8‐azidoguanosine 5′‐triphosphate (8N3GTP) has been shown to be a biological mimic of GRP in this system and, also, an effective active site probe of the exchangeable GRP binding site.
S, Khatoon, S R, Campbell, B E, Haley, J T, Slevin   +3 more
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Direct photoaffinity labeling of tubulin with guanosine 5'-triphosphate

Biochemistry, 1985
Irradiation of tubulin in the presence of [3H]GTP or [3H]GDP at 254 nm led to the covalent incorporation of nucleotide into the protein. The specific nature of the labeling was shown in the following manner: with tubulin depleted of exchangeable nucleotide, the amount of labeling increased to a plateau value as the [3H]GTP concentration was increased ...
J P, Nath, G R, Eagle, R H, Himes
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Preparative method of obtaining guanosine 5′-triphosphate

Chemistry of Natural Compounds, 1965
1. The kinetics of the formation of guanosine 5′-triphosphate, 5′-diphosphate, and 5′-monophosphate in the reaction of the morpholide of guanosine 5′-monophosphate with bis-(tributylammonium) pyrophosphate in pyridine at 27° has been recorded. 2. In the reaction of the morpholide of guanosine 5′-monophosphate with bis-(tributylammonium) pyrophosphate ...
T. S. Lomakina, N. I. Grineva
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Adenosine Triphosphate and Guanosine Triphosphate Determinations in Intertidal Sediments

1979
Measurements were made of the spatial distributions of adenosine triphosphate (ATP) on a variety of sandy beaches. Samples were collected during ebb flow and extracted in the field using cold sulfuric acid and ethylenediamine tetraacetate (EDTA); the neutralized extracts were immediately frozen for subsequent analyses.
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Guanosine-5?-triphosphate hydrolysis and tubulin polymerization

Molecular and Cellular Biochemistry, 1982
GTP hydrolysis associated with polymerization is a distinctive feature of microtubule assembly. This reaction may be fundamentally linked to the dynamic properties of microtubules in vivo. Kinetic analysis of the connection between microtubule assembly and associated GTP hydrolysis indicates that these two events are kinetically uncoupled, GTP ...
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Acid-Cleavable Guanosine Triphosphate-Photoaffinity Probe for Global Profiling of Guanosine Triphosphate-Binding Proteins and Their Active Sites

Analytical Chemistry
Guanosine triphosphate (GTP)-binding proteins function as molecular switches in cell signaling, playing critical roles in various biological pathways. Their dysregulation is associated with the causes and progression of many diseases. Systematic analysis of GTP-binding proteins would facilitate studies of related signaling pathways and drugs ...
Can Gao, Mengxuan Li, Jing Tan, Zhiming Wang, Jing Xu, Wenwen Li, Feng Shi, Zhenzhen Chen, Rong Cai   +8 more
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Evidence for Guanosine Triphosphate—Binding Proteins in Trypanosoma cruzi

The American Journal of Tropical Medicine and Hygiene, 1994
The transformation of the parasite Trypanosoma cruzi from the blood-borne trypomastigote to the intracellular amastigote constitutes a key clinical feature in the pathophysiology of Chagas' disease. That this transition occurs without change in the integrity of the plasma membrane of the parasite suggests the presence of biochemical structures, i.e ...
H S, Oz, H, Huang, M, Wittner, H B, Tanowitz, J P, Bilezikian, S A, Morris   +5 more
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Autosomal dominant guanosine triphosphate cyclohydrolase I deficiency (Segawa disease)

Annals of Neurology, 2003
Autosomal dominant guanosine triphosphate cyclohydrolase I (GCH-I) deficiency (Segawa disease) is a dopa-responsive dystonia caused by mutation of the GCH-I gene located on 14q22.1-q22.2. Neurohistochemical examination revealed a decrease of the tyrosine hydroxylase protein as well as its activity in the striatum and decrease of dopamine content ...
Masaya, Segawa, Yoshiko, Nomura, Nobuyoshi, Nishiyama   +2 more
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Guanosine triphosphate cyclohydrolase 1 promoter deletion causes dopa‐responsive dystonia

Movement Disorders, 2012
AbstractBackground:Autosomal dominant dopa‐responsive dystonia (AD‐DRD) is caused by a biochemical defect primarily resulting from guanosine triphosphate cyclohydrolase 1 gene (GCH1) mutations. Few families have been reported without mutations in GCH1.Methods:Genome‐wide linkage analysis and positional cloning to identify the genetic defect in a ...
Theuns, Jessie, Crosiers, David, Debaene, Luc, Nuytemans, Karen, Meeus, Bram, Sleegers, Kristel, Goossens, Dirk, Corsmit, Ellen, Elinck, Ellen, Peeters, Karin, Mattheijssens, Maria, Pickut, Barbara, Del-Favero, Jurgen, Engelborghs, Sebastiaan, De Deyn, Peter Paul, Cras, Patrick, Van Broeckhoven, Christine   +16 more
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ChemInform Abstract: Preparative Enzymatic Conversion of Guanosine 5′‐Monophosphate to Guanosine 5′‐Triphosphate.

ChemInform, 1991
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
R. STILLER, J. THIEM
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