Results 31 to 40 of about 162,062 (330)

Preparation of Isotope-labeled Dihydroneopterin 3'-Triphosphate with High Specific Activity

Pteridines, 1990
Isotope-labeled dihydroneopterin 3'-triphosphate with 3H at positions C-1' and C-2', respectively, has been prepared from isotope-labeled glucose as starting material. Glucose was first converted enzymatically to ribose 5-phosphate.
Katzenmeier Gerd, Schwarzkopf Bruno, Van Quang Le, Schmid Cornelia, Bacher Adelbert   +4 more
doaj   +1 more source

DNA sensor cGAS-mediated immune recognition

Protein & Cell, 2016
The host takes use of pattern recognition receptors (PRRs) to defend against pathogen invasion or cellular damage. Among microorganism-associated molecular patterns detected by host PRRs, nucleic acids derived from bacteria or viruses are tightly ...
Pengyan Xia, Shuo Wang, Pu Gao, Guangxia Gao, Zusen Fan   +4 more
doaj   +1 more source

Mechanisms of microtubule dynamics and force generation examined with computational modeling and electron cryotomography

Nature Communications, 2020
Microtubules are dynamic tubulin polymers which elongate by addition of bent guanosine triphosphate tubulin to the tips of curving protofilaments. Here authors use Brownian dynamics modeling and electron cryotomography to show that the lateral activation
Nikita B. Gudimchuk, Evgeni V. Ulyanov, Eileen O’Toole, Cynthia L. Page, Dmitrii S. Vinogradov, Garry Morgan, Gabriella Li, Jeffrey K. Moore, Ewa Szczesna, Antonina Roll-Mecak, Fazoil I. Ataullakhanov, J. Richard McIntosh   +11 more
doaj   +1 more source

Ligand-Specific Regulation of the Endogenous Mu-Opioid Receptor by Chronic Treatment with Mu-Opioid Peptide Agonist [PDF]

, 2013
Since the discovery of the endomorphins (EM), the postulated endogenous peptide agonists of the mu-opioid receptors, several analogues have been synthesized to improve their binding and pharmacological profiles.
Birkás, Erika, Bozó, Beáta, Cinar, Resat, Dochnal, Roberta Beatrix, Fábián, Gabriella, Kicsi, Emese Gabriella, Kékesi, Orsolya, Murányi, Marianna, Mácsai, Mónika, Szabó, Gyula, Szűcs, Mária, Tóth, Géza, Zentai, András   +12 more
core   +3 more sources

RhoB regulates cell migration through altered focal adhesion dynamics [PDF]

Open Biology, 2012
The Rho GTPase RhoB has been shown to affect cell migration, but how it does this is not clear. Here we show that cells depleted of RhoB by RNAi are rounded and have defects in Rac-mediated spreading and lamellipodium extension, although they have active
Francisco M. Vega, Audrey Colomba, Nicolas Reymond, Mairian Thomas, Anne J. Ridley   +4 more
doaj   +1 more source

3.6.5.2 Small monomeric GTPases in GtoPdb v.2023.1 [PDF]

, 2023
Small G-proteins, are a family of hydrolase enzymes that can bind and hydrolyze guanosine triphosphate (GTP). They are a type of G-protein found in the cytosol that are homologous to the alpha subunit of heterotrimeric G-proteins, but unlike the alpha ...
Faccenda, Elena
core   +2 more sources

Hydrolysis of Guanosine Triphosphate (GTP) by the Ras·GAP Protein Complex: Reaction Mechanism and Kinetic Scheme.

Journal of Physical Chemistry B, 2015
Molecular mechanisms of the hydrolysis of guanosine triphosphate (GTP) to guanosine diphosphate (GDP) and inorganic phosphate (Pi) by the Ras·GAP protein complex are fully investigated by using modern modeling tools. The previously hypothesized stages of
M. Khrenova, B. Grigorenko, A. Kolomeisky, A. Nemukhin   +3 more
semanticscholar   +1 more source

Selective [9-¹⁵N] Guanosine for Nuclear Magnetic Resonance Studies of Large Ribonucleic Acids. [PDF]

Chembiochem
The small chemical shift anisotropy of nitrogen‐15 at the 9‐position in guanine (15N9‐G) leads to long T2 values and narrow NMR lines, particularly attractive to probe structure and dynamics of large (>200 nucleotide) ribonucleic acids (RNAs). RNAs regulate various cellular processes using malleable 3D structures, and understanding the factors that ...
Attionu SK, Dill R, Summers MF, Case DA, Marchant J, Dayie TK.   +5 more
europepmc   +2 more sources

GTP and Ca2+ Modulate the Inositol 1,4,5-Trisphosphate-Dependent Ca2+ Release in Streptolysin O-Permeabilized Bovine Adrenal Chromaffin Cells [PDF]

, 1991
The inositol 1,4,5-trisphosphate (IP3)-induced Ca2+ release was studied using streptolysin O-permeabilized bovine adrenal chromaffin cells. The IP3-induced Ca2+ release was followed by Ca2+ reuptake into intracellular compartments.
Ahnert-Hilger G., Ahnert-Hilger G., B. Stecher, Bhakdi S., Bhakdi S., Brass L. F., Chueh S.-H., Comerford J. G., Danoff S. K., Dawson A. P., Fohr K. J., G. Ahnert-Hilger, Hirata M., Hugo F., J. Scott, Joseph S. K., K. J. Föhr, Kao L.-S., Livett B., M. Gratzl, Rossier M. F., Stoehr S. J., Supattapone S., Worley P. F.   +23 more
core   +1 more source

Light-driven artificial enzymes for selective oxidation of guanosine triphosphate using water-soluble POSS network polymers.

Organic and biomolecular chemistry, 2014
The light-driven artificial enzymes were constructed to realize unnatural reactions concerning bio-significant molecules. In this manuscript, the guanosine triphosphate (GTP)-selective oxidation is reported using the network polymers composed of ...
Jonghwan Jeon, Kazuo Tanaka, Y. Chujo
semanticscholar   +1 more source