Results 1 to 10 of about 91,722 (226)
The nitric oxide–soluble guanylate cyclase–cGMP pathway in pulmonary hypertension: from PDE5 to soluble guanylate cyclase [PDF]
European Respiratory ReviewThe nitric oxide (NO)–soluble guanylate cyclase (sGC)–cyclic guanosine monophosphate (cGMP) pathway plays a key role in the pathogenesis of pulmonary hypertension (PH).
Raymond L. Benza +4 more
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Current Modulation of Guanylate Cyclase Pathway Activity—Mechanism and Clinical Implications
Molecules, 2021 For years, guanylate cyclase seemed to be homogenic and tissue nonspecific enzyme; however, in the last few years, in light of preclinical and clinical trials, it became an interesting target for pharmacological intervention.
Grzegorz Grześk, Alicja Nowaczyk
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Activation mechanism of human soluble guanylate cyclase by stimulators and activators
Nature Communications, 2021 Soluble guanylate cyclase (sGC) is a validated drug target for cardiovascular diseases. Here, the authors report structures of human sGC in complex with NO and sGC stimulators or activator, providing insight into the mechanism of sGC activation by ...
Rui Liu, Yunlu Kang, Lei Chen
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Developments in Molecular and Cellular Biochemistry, 2020 Guanylatecyclase (guanylylcyclase, GC) is a lyase enzyme. Guanylylcyclase is often part of the G protein signaling cascade that is activated by low intracellular calcium levels and inhibited by high intracellular calcium levels.
Rameshwar K. Sharma
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Decoding signaling mechanisms: unraveling the targets of guanylate cyclase agonists in cardiovascular and digestive diseases [PDF]
Frontiers in Pharmacology, 2023 Soluble guanylate cyclase agonists and guanylate cyclase C agonists are two popular drugs for diseases of the cardiovascular system and digestive systems. The common denominator in these conditions is the potential therapeutic target of guanylate cyclase.
Qinan Yin +15 more
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Multilimbed membrane guanylate cyclase signaling system, evolutionary ladder [PDF]
Frontiers in Molecular Neuroscience, 2023 One monumental discovery in the field of cell biology is the establishment of the membrane guanylate cyclase signal transduction system. Decoding its fundamental, molecular, biochemical, and genetic features revolutionized the processes of developing ...
Teresa Duda, Rameshwar K. Sharma
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Frontiers in Molecular Neuroscience, 2018 Over 100 mutations in GUCY2D that encodes the photoreceptor guanylate cyclase GC-E are known to cause two major diseases: autosomal recessive Leber congenital amaurosis (arLCA) or autosomal dominant cone-rod dystrophy (adCRD) with a poorly understood ...
Hanna Wimberg +8 more
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PLoS ONE, 2011 Zebrafish express in their retina a higher number of guanylate cyclase-activating proteins (zGCAPs) than mammalians pointing to more complex guanylate cyclase signaling systems.
Alexander Scholten, Karl-Wilhelm Koch
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Structural basis of retinal membrane guanylate cyclase regulation by GCAP1 and RD3 [PDF]
Frontiers in Molecular Neuroscience, 2022 Retinal membrane guanylate cyclases (RetGC1 and RetGC2) are expressed in photoreceptor rod and cone cells, where they promote the onset of visual recovery during phototransduction.
James B. Ames
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Analysis of research trends and development prospects of soluble guanylate cyclase stimulators/activators: using bibliometric methods [PDF]
Frontiers in PharmacologyBackgroundThe stimulation and activation of soluble guanylate cyclase (sGC) has been a prominent focus of study in recent years. Currently, sGC stimulators/activators have a wide range of applications in various fields.
Bing Ju Yan +3 more
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