Decoding signaling mechanisms: unraveling the targets of guanylate cyclase agonists in cardiovascular and digestive diseases [PDF]
Frontiers in Pharmacology, 2023 Soluble guanylate cyclase agonists and guanylate cyclase C agonists are two popular drugs for diseases of the cardiovascular system and digestive systems. The common denominator in these conditions is the potential therapeutic target of guanylate cyclase.
Qinan Yin +15 more
doaj +2 more sources
Multilimbed membrane guanylate cyclase signaling system, evolutionary ladder [PDF]
Frontiers in Molecular Neuroscience, 2023 One monumental discovery in the field of cell biology is the establishment of the membrane guanylate cyclase signal transduction system. Decoding its fundamental, molecular, biochemical, and genetic features revolutionized the processes of developing ...
Teresa Duda, Rameshwar K. Sharma
doaj +2 more sources
Current Modulation of Guanylate Cyclase Pathway Activity—Mechanism and Clinical Implications [PDF]
Molecules, 2021 For years, guanylate cyclase seemed to be homogenic and tissue nonspecific enzyme; however, in the last few years, in light of preclinical and clinical trials, it became an interesting target for pharmacological intervention.
Grzegorz Grześk, Alicja Nowaczyk
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Structural basis of retinal membrane guanylate cyclase regulation by GCAP1 and RD3 [PDF]
Frontiers in Molecular Neuroscience, 2022 Retinal membrane guanylate cyclases (RetGC1 and RetGC2) are expressed in photoreceptor rod and cone cells, where they promote the onset of visual recovery during phototransduction.
James B. Ames
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Differential calcium signaling by cone specific guanylate cyclase-activating proteins from the zebrafish retina. [PDF]
PLoS ONE, 2011 Zebrafish express in their retina a higher number of guanylate cyclase-activating proteins (zGCAPs) than mammalians pointing to more complex guanylate cyclase signaling systems.
Alexander Scholten, Karl-Wilhelm Koch
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Soluble guanylate cyclase α1-deficient mice: a novel murine model for primary open angle glaucoma. [PDF]
PLoS ONE, 2013 Primary open angle glaucoma (POAG) is a leading cause of blindness worldwide. The molecular signaling involved in the pathogenesis of POAG remains unknown.
Emmanuel S Buys +29 more
doaj +8 more sources
The nitric oxide–soluble guanylate cyclase–cGMP pathway in pulmonary hypertension: from PDE5 to soluble guanylate cyclase [PDF]
European Respiratory ReviewThe nitric oxide (NO)–soluble guanylate cyclase (sGC)–cyclic guanosine monophosphate (cGMP) pathway plays a key role in the pathogenesis of pulmonary hypertension (PH).
Raymond L. Benza +4 more
doaj +2 more sources
Aortic disease in Marfan syndrome is caused by overactivation of sGC-PRKG signaling by NO [PDF]
Nature Communications, 2021 Aortic aneurysm and dissection, the major problem linked to Marfan syndrome (MFS), lacks effective pharmacological treatment. Here, the authors show that the NO pathway is overactivated in MFS and that inhibition of guanylate cyclase and cGMP-dependent ...
Andrea de la Fuente-Alonso +20 more
doaj +4 more sources
Soluble Guanylate Cyclase Activators to Treat Benign Prostatic Hyperplasia and associated LUTS [PDF]
Continence, 2023 This review summarises the presentations during a workshop session entitled “The Use of Soluble Guanylate Cyclase Activators to Treat Benign Prostatic Hyperplasia, Obstruction and Fibrosis – Mechanistic Concepts and Clinical Implications” at the ...
A.J. Kanai +3 more
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A Phase II study of avenciguat, a novel soluble guanylate cyclase activator, in patients with systemic sclerosis: Study design and rationale of the VITALISScE™ study. [PDF]
J Scleroderma Relat DisordINTRODUCTION Systemic sclerosis is a rare autoimmune connective tissue disease characterised by (1) microvasculopathy; (2) immune dysregulation; and (3) progressive fibrosis of the skin and internal organs. Soluble guanylate cyclase plays an important
Khanna D +9 more
europepmc +3 more sources