Decoding signaling mechanisms: unraveling the targets of guanylate cyclase agonists in cardiovascular and digestive diseases [PDF]
Frontiers in Pharmacology, 2023 Soluble guanylate cyclase agonists and guanylate cyclase C agonists are two popular drugs for diseases of the cardiovascular system and digestive systems. The common denominator in these conditions is the potential therapeutic target of guanylate cyclase.
Qinan Yin +15 more
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Soluble guanylate cyclase α1-deficient mice: a novel murine model for primary open angle glaucoma. [PDF]
PLoS ONE, 2013 Primary open angle glaucoma (POAG) is a leading cause of blindness worldwide. The molecular signaling involved in the pathogenesis of POAG remains unknown.
Emmanuel S Buys +29 more
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Multilimbed membrane guanylate cyclase signaling system, evolutionary ladder [PDF]
Frontiers in Molecular Neuroscience, 2023 One monumental discovery in the field of cell biology is the establishment of the membrane guanylate cyclase signal transduction system. Decoding its fundamental, molecular, biochemical, and genetic features revolutionized the processes of developing ...
Teresa Duda, Rameshwar K. Sharma
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The nitric oxide–soluble guanylate cyclase–cGMP pathway in pulmonary hypertension: from PDE5 to soluble guanylate cyclase [PDF]
European Respiratory ReviewThe nitric oxide (NO)–soluble guanylate cyclase (sGC)–cyclic guanosine monophosphate (cGMP) pathway plays a key role in the pathogenesis of pulmonary hypertension (PH).
Raymond L. Benza +4 more
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Structural basis of retinal membrane guanylate cyclase regulation by GCAP1 and RD3 [PDF]
Frontiers in Molecular Neuroscience, 2022 Retinal membrane guanylate cyclases (RetGC1 and RetGC2) are expressed in photoreceptor rod and cone cells, where they promote the onset of visual recovery during phototransduction.
James B. Ames
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Analysis of research trends and development prospects of soluble guanylate cyclase stimulators/activators: using bibliometric methods [PDF]
Frontiers in PharmacologyBackgroundThe stimulation and activation of soluble guanylate cyclase (sGC) has been a prominent focus of study in recent years. Currently, sGC stimulators/activators have a wide range of applications in various fields.
Bing Ju Yan +3 more
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Soluble Guanylate Cyclase Activators to Treat Benign Prostatic Hyperplasia and associated LUTS [PDF]
Continence, 2023 This review summarises the presentations during a workshop session entitled “The Use of Soluble Guanylate Cyclase Activators to Treat Benign Prostatic Hyperplasia, Obstruction and Fibrosis – Mechanistic Concepts and Clinical Implications” at the ...
A.J. Kanai +3 more
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Editorial: Multi-limbed membrane guanylate cyclase cellular signaling pathways [PDF]
Frontiers in Molecular Neuroscience, 2023 Rameshwar K. Sharma +3 more
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Current Modulation of Guanylate Cyclase Pathway Activity—Mechanism and Clinical Implications
Molecules, 2021 For years, guanylate cyclase seemed to be homogenic and tissue nonspecific enzyme; however, in the last few years, in light of preclinical and clinical trials, it became an interesting target for pharmacological intervention.
Grzegorz Grześk, Alicja Nowaczyk
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Inhaled mosliciguat (BAY 1237592): targeting pulmonary vasculature via activating apo-sGC
Respiratory Research, 2022 Background Oxidative stress associated with severe cardiopulmonary diseases leads to impairment in the nitric oxide/soluble guanylate cyclase signaling pathway, shifting native soluble guanylate cyclase toward heme-free apo-soluble guanylate cyclase ...
Eva M. Becker-Pelster +18 more
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