Results 11 to 20 of about 40,840 (280)
Frontiers in Molecular Neuroscience, 2018 Over 100 mutations in GUCY2D that encodes the photoreceptor guanylate cyclase GC-E are known to cause two major diseases: autosomal recessive Leber congenital amaurosis (arLCA) or autosomal dominant cone-rod dystrophy (adCRD) with a poorly understood ...
Dorit Lev, Karl-wilhelm Koch
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Adenylate Cyclase and Guanylate Cyclase in Myxococcus xanthus [PDF]
Microbiology, 1984 Myxococcus xanthus M300 vegetative cells contained significant amounts of adenylate and guanylate cyclase activity. The latter was distributed between the 100000 g supernatant and pellet fractions, required divalent cations for activity and exhibited an apparent Km of 1 mm.
A. L. DEVI, Howard D. McCurdy
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Editorial: Multi-limbed membrane guanylate cyclase cellular signaling pathways [PDF]
Frontiers in Molecular Neuroscience, 2023 Rameshwar K. Sharma +3 more
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Inhaled mosliciguat (BAY 1237592): targeting pulmonary vasculature via activating apo-sGC
Respiratory Research, 2022 Background Oxidative stress associated with severe cardiopulmonary diseases leads to impairment in the nitric oxide/soluble guanylate cyclase signaling pathway, shifting native soluble guanylate cyclase toward heme-free apo-soluble guanylate cyclase ...
Eva M. Becker-Pelster +18 more
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Pulse, 2023 Introduction: A previous study of 200,000 exome-sequenced UK Biobank participants to test for association of rare coding variants with hypertension implicated two genes at exome-wide significance, DNMT3A and FES.
David Curtis
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Identification of bacterial guanylate cyclases [PDF]
Proteins: Structure, Function, and Bioinformatics, 2017 The ability of bacteria to use cGMP as a second messenger has been controversial for decades. Recently, nucleotide cyclases from Rhodospirillum centenum, GcyA, and Xanthomonas campestris, GuaX, have been shown to possess guanylate cyclase activities. Enzymatic activities of these guanylate cyclases measured in vitro were low, which makes interpretation
Hwan Youn +3 more
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Crystal structures of the catalytic domain of human soluble guanylate cyclase. [PDF]
PLoS ONE, 2013 Soluble guanylate cyclase (sGC) catalyses the synthesis of cyclic GMP in response to nitric oxide. The enzyme is a heterodimer of homologous α and β subunits, each of which is composed of multiple domains.
Charles K Allerston +2 more
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Кардиоваскулярная терапия и профилактика, 2021 Heart failure is a severe disease with an unfavorable prognosis, which requires intensification of therapy and the search for novel approaches to treatment.
Zh. D. Kobalava, P. V. Lazarev
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Cytoglobin regulates NO-dependent cilia motility and organ laterality during development
Nature Communications, 2023 Cytoglobin is a heme protein with unresolved physiological function. Genetic deletion of zebrafish cytoglobin (cygb2) causes developmental defects in left-right cardiac determination, which in humans is associated with defects in ciliary function and low
Elizabeth R. Rochon +12 more
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Amyloid-β inhibits No-cGMP signaling in a CD36- and CD47-dependent manner. [PDF]
PLoS ONE, 2010 Amyloid-β interacts with two cell surface receptors, CD36 and CD47, through which the matricellular protein thrombospondin-1 inhibits soluble guanylate cyclase activation. Here we examine whether amyloid-β shares this inhibitory activity.
Thomas W Miller +4 more
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