Results 251 to 260 of about 40,840 (280)
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1989
Following the discovery of adenylate cyclase (Sutherland et al. 1962), the enzyme guanylate cyclase was identified (Hardman and Sutherland 1969; Schultz et al. 1969; White and Aurbach 1969). By the time of its discovery, the “second messenger hypothesis” was well in place and it was initially felt that the mechanisms by which guanylate cyclase were ...
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Following the discovery of adenylate cyclase (Sutherland et al. 1962), the enzyme guanylate cyclase was identified (Hardman and Sutherland 1969; Schultz et al. 1969; White and Aurbach 1969). By the time of its discovery, the “second messenger hypothesis” was well in place and it was initially felt that the mechanisms by which guanylate cyclase were ...
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Soluble guanylate cyclase: the forgotten sibling
Trends in Pharmacological Sciences, 1997Despite widespread distribution in most mammalian cells, the role of soluble guanylate cyclase has, until recently, been poorly defined, especially when compared with its more illustrious sibling, adenylate cyclase. In this review Adrian Hobbs outlines some of the reasons why the soluble guanylate cyclase-cGMP pathway has remained outside the ...
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Activation of kidney guanylate cyclase by cobalt
Archives of Biochemistry and Biophysics, 1978Abstract Guanylate cyclase activity and cyclic nucleotide content were studied in individual slices from guinea pig kidneys. Basal guanylate cyclase activity, assayed in homogenates or in particulate fractions (100,000g × 1 h), and the tissue content of cGMP and cAMP were greater in the inner than in the outer (entirely cortical) slices. The fraction
Su-Chen Tsai +2 more
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Detection of guanyl cyclase in mammalian tissues
Biochimica et Biophysica Acta (BBA) - Enzymology, 1969Abstract Guanyl cyclase was assayed by determining the rate of conversion of [ α - 32 P ]GTP to cyclic 3′,5′-[ 32 P]GMP. A two-step chromatographic procedure was developed for isolating the product. The enzyme was found in the soluble fraction after homogenizing tissues in 0.3 M sucrose. The reaction showed a pH optimum near 7.6 and was dependent on
Arnold A. White, Gerald D. Aurbach
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Transmembrane guanylate cyclase in intestinal pathophysiology
Current Opinion in Gastroenterology, 2011Production of cyclic guanosine monophosphate (cGMP) by guanylate cyclase is of critical importance to gastrointestinal physiology. Tight regulation of cGMP concentration is necessary for proper intestinal secretion and intestinal epithelial cell proliferative and apoptotic homeostasis.
Kris A. Steinbrecher, Mitchell B. Cohen
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Plasma Membrane Guanylate Cyclase
1997Cyclic GMP was discovered in rat urine (Ashman et al., 1963) at almost the same time the remarkable discovery of cyclic AMP was made (Sutherland and Rall, 1960). Mimicking the conceptual framework formulated for the second messenger role of cyclic AMP, cyclic GMP was also proposed to act as a second messenger of certain hormonal signals (reviewed in ...
Teresa Duda, Rameshwar K. Sharma
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BROMOCRIPTINE ENHANCES GUANYLATE CYCLASE ACTIVITY
Endocrinology, 1981Bromocriptine and its parent compound alpha-ergocryptine were investigated with respect to their ability to interact with the guanylate cyclase (E.C.4.6.1.2)-cyclic GMP system in vitro in the rat pituitary and ovary. Both bromocriptine and alpha-ergocryptine enhanced guanylate cyclase two- to threefold in both of these tissues over a concentration ...
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Phencyclidine stimulates guanylate cyclase activity
Biochemical and Biophysical Research Communications, 1979Abstract The hallucinogenic agents, phencylidine (Angel's Dust), TCP ∗ and their morpholine analogs enhanced the activity of guanylate cyclase {E.C.4.6.1.2}, the enzyme that catalyzes the production of guanosine 3′, 5′-monophosphate. This activation of guanylate cyclase by hencyclidine and TCP was observed over the concentration range of .00001 mM ...
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Subcellular localization of guanylate cyclase
Life Sciences, 1975Hiroshi Kimura, Ferid Murad
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Guanylate Cyclase: Properties and Regulation
1982Cyclic GMP was discovered in biological material in 19631, and guanylate cyclase, the enzyme that catalyzes the formation of the cyclic nucleotide from GTP, was first described in 19692–5. Because of its chemical similarity to cyclic AMP, cyclic GMP has long been assumed to be involved in cellular regulation.
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