Portopulmonary hypertension practice patterns after liver transplantation
Liver Transplantation, EarlyView., 2022 Abstract Portopulmonary hypertension (POPH) is a type of pulmonary arterial hypertension occurring exclusively in those with portal hypertensive liver disease. Liver transplantation (LT) can significantly improve outcomes. Current guidelines counsel against immediate adjustments to targeted therapy after LT and suggest routine echocardiography as ...
Arun Jose +3 more
wiley +1 more source
Should the non‐canonical pathway of nitric oxide generation be targeted in hypertensive pregnancies?
British Journal of Pharmacology, EarlyView., 2023 Abstract Hypertension in pregnancy is prevalent, affecting around 10% of pregnancies worldwide, and significantly increases the risk of adverse outcomes for both mothers and their babies. Current treatment strategies for pregnant women with hypertension are limited, and new approaches for the management of hypertension in pregnancy are urgently needed.
Elizabeth C. Cottrell
wiley +1 more source
The soluble guanylate cyclase stimulator named vericiguat as an innovative heart failure therapy representative [PDF]
Farmacja Polska, 2021 A noticeable trend towards greater heart failure morbidity is observed in Poland as well as in the whole world. The percentage of people living with the above mentioned disease is growing mostly due to the process of ageing of populations.
Beata Jacuś +3 more
doaj +1 more source
Halothane and the Guanylate Cyclase System [PDF]
Anesthesiology, 1993 Kumi Nakamura +2 more
openalex +3 more sources
A model of the intracellular response of an olfactory neuron in Caenorhabditis elegans to odor stimulation. [PDF]
PLoS ONE, 2012 We developed a mathematical model of a hypothetical neuronal signal transduction pathway to better understand olfactory perception in Caenorhabditis elegans. This worm has only three pairs of olfactory receptor neurons.
Mamoru Usuyama +2 more
doaj +1 more source
Regulation of intracellular cyclic GMP concentration by light and calcium in electropermeabilized rod photoreceptors. [PDF]
, 1994 This study examines the regulation of cGMP by illumination and by calcium during signal transduction in vertebrate retinal photoreceptor cells. We employed an electropermeabilized rod outer segment (EP-ROS) preparation which permits perfusion of low ...
Coccia, V J, Cote, Rick H.
core +2 more sources
Structural diversity of neuronal calcium sensor proteins and insights for activation of retinal guanylyl cyclase by GCAP1. [PDF]
, 2014 Neuronal calcium sensor (NCS) proteins, a sub-branch of the calmodulin superfamily, are expressed in the brain and retina where they transduce calcium signals and are genetically linked to degenerative diseases.
Ames, James B +2 more
core +2 more sources
Zebrafish guanylate cyclase type 3 signaling in cone photoreceptors. [PDF]
PLoS ONE, 2013 The zebrafish guanylate cyclase type 3 (zGC3) is specifically expressed in cone cells. A specifc antibody directed against zGC3 revealed expression at the protein level at 3.5 dpf in outer and inner retinal layers, which increased in intensity between 3 ...
Ramona Fries +3 more
doaj +1 more source
Neurogastroenterology &Motility, Volume 34, Issue 12, December 2022., 2022 In women with IBS‐D, vibegron was not associated with significant improvement in the percentage of API weekly responders. Vibegron was generally safe and well tolerated and, in particular, did not worsen IBS symptoms vs. placebo. Abstract Background Preclinical and clinical studies suggest that β3‐adrenergic receptor activation may be a novel target ...
Brian E. Lacy +5 more
wiley +1 more source
The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase [PDF]
, 2008 Background Soluble guanylate cyclases generate cyclic GMP when bound to nitric oxide, thereby linking nitric oxide levels to the control of processes such as vascular homeostasis and neurotransmission. The guanylate cyclase catalytic module, for which no
Derbyshire, Emily R +4 more
core +3 more sources