Results 61 to 70 of about 40,447 (213)
Is there NO treatment for severe sepsis? [PDF]
, 2008 Sepsis is a systemic inflammatory response syndrome in the presence of suspected or proven infection, and it may progress to or encompass organ failure (severe sepsis) and hypotension (septic shock).
Bredan, Amin, Cauwels, Anje
core +2 more sources
Journal of Pediatric Gastroenterology and Nutrition, EarlyView.Abstract Objectives Pediatric intestinal pseudo‐obstruction (PIPO) is a severe bowel motility disorder characterized by impaired propulsion of gastrointestinal contents without mechanical obstruction. PIPO encompasses congenital and acquired disorders, including neuropathies, myopathies, and mesenchymopathies.
Sharon Wolfson +8 more
wiley +1 more source
Frontiers in Molecular Neuroscience, 2012 The membrane guanylate cyclase family has been branched into three subfamilies: natriuretic peptide hormone surface receptors, Ca2+-modulated neuronal ROS-GC, and Ca2+-modulated odorant surface receptor ONE-GC.
Teresa eDuda +3 more
doaj +1 more source
Nature Communications, 2021 The emergence of acquired resistance to standard platinum-etoposide chemotherapy in small cell lung cancer (SCLC) is a common event. Here, the authors using paired pre-treatment and post-chemotherapy circulating tumour cell patient-derived explant (CDX ...
Maximilian W. Schenk +18 more
doaj +1 more source
Vericiguat: The Fifth Harmony of Heart Failure with Reduced Ejection Fraction
Journal of Cardiovascular Development and Disease, 2023 Heart failure with reduced ejection fraction is a chronic and progressive syndrome that continues to be a substantial financial burden for health systems in Western countries. Despite remarkable advances in pharmacologic and device-based therapy over the
Luigi Falco +8 more
doaj +1 more source
Repurposing Riociguat for Treatment of Refractory Angina Resulting From Coronary Spasm
JACC: Case Reports, 2021 Coronary spasm is a frequent cause of angina despite unobstructed coronary arteries, and symptom control with recommended drugs is limited. We report the case of a 77-year-old woman who had refractory angina despite conventional antianginal treatment ...
Valeria Martínez Pereyra, MS +8 more
doaj +1 more source
Mass Spectrometry Reviews, EarlyView.ABSTRACT Nitrooxidative stress, driven by excess reactive nitrogen species like peroxynitrite, contributes to the pathogenesis of many chronic diseases. Among its molecular footprints, 3‐nitrotyrosine (3NT) has emerged as a biologically relevant marker of protein nitration.
Brîndușa Alina Petre
wiley +1 more source
Bicarbonate and Ca2+ sensing modulators activate photoreceptor ROS-GC1 synergistically
Frontiers in Molecular Neuroscience, 2016 Photoreceptor ROS-GC1, a prototype subfamily member of the membrane guanylate cyclase family, is a central component of phototransduction. It is a single transmembrane-spanning protein, composed of modular blocks.
Teresa eDuda +3 more
doaj +1 more source
Photoreceptor Guanylate Cyclases: A Review
Bioscience Reports, 1997 Almost three decades of research in the field of photoreceptor guanylate cyclases are discussed in this review. Primarily, it focuses on the members of membrane-bound guanylate cyclases found in the outer segments of vertebrate rods. These cyclases represent a new guanylate cyclase subfamily, termed ROS-GC, which distinguishes itself from the peptide ...
E N, Pugh +3 more
openaire +2 more sources
Nitric oxide binds to the proximal heme coordination site of the ferrocytochrome c/cardiolipin complex: formation mechanism and dynamics. [PDF]
, 2010 Mammalian mitochondrial cytochrome c interacts with cardiolipin to form a complex (cyt. c/CL) important in apoptosis. Here we show that this interaction leads to structural changes in ferrocytochrome c that leads to an open coordinate site on the central
Husu, I +4 more
core +4 more sources