Results 91 to 100 of about 102,937 (395)
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Priority Interests of the Child When Choosing a Candidate for Guardianship (Trustees)
Сибирское юридическое обозрение, 2011 The present study concerce one of the most important institutions of the Russian law - custody and guardianship of minors. With the adoption of the Federal Law on Guardianship and Custody there appeared provisions that had made changes in the legal ...
Rarpi Vaganovna Tovmasyan
doaj
Material Rights of Children in Guardianship Maqashid al Sharia Perspective
NuraniThe material rights of children in the ruling of religious court judges are a very important issue to be studied in relation to the protection of children's rights in guardianship.
Arne Huzaimah, M. Tamudin
doaj +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Sichuan jingshen weishengBackgroundThe guardianship ability of guardians of patients with severe mental disorders plays an important role in supporting the patients' recovery and reintegration into society.
Duan Xiaoling +5 more
doaj +1 more source
El devenir de la Representación Política de los Niños y las Niñas
Revista Latinoamericana en Ciencias Sociales, Niñez y Juventud, 2014 The article makes a historical follow-up of the ways how the child has been regarded from the classical Greek world to the condition of a full citizen capable of questioning the adult world.
Ingrit Gutiérrez, Alejandro Acosta
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Evaluating Decision Making Capacity in Older Individuals: Does the Law Give a Clue?
Laws, 2015 Adequate cognitive and emotional capacity is essential to autonomous decision making by adult medical patients. Society often attaches legal consequences to decisional capacity evaluations.
Marshall B. Kapp
doaj +1 more source
Understanding Duties and Conflicts of Interest--A Guide for the Honorable Agent [PDF]
, 2013 This article examines the importance of understanding agent duties and conflicts of interest, both for drafting a power of attorney that meets a principal’s objectives and for providing guidance to the agent who will act under its authority.
Whitton, Linda S.
core +2 more sources