Results 51 to 60 of about 17,282 (302)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Family mediation: problems of negotiability and domestic violence in the focus of professional discourse (on the materials of sociological research)

open access: yesЦифровая социология
The article is devoted to a sociological analysis of the opinions of family mediation specialists on the problems of spousal negotiability and domestic violence.
O. E. Gracheva, I. V. Mkrtumova
doaj   +1 more source

Knowledge guardianship, custodianship and ethics: a Melanesian perspective

open access: yesAlterNative: An International Journal of Indigenous Peoples, 2020
Across the world, knowledge communities categorise and attach conditions of guardianship to different kinds of knowledge. For private or secret knowledge, those responsible for its care have obligations for arranging and restricting transmission to ...
Kabini F Sanga, Martyn Reynolds
semanticscholar   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Mediation in Guardianship Proceedings for the Elderly: An Australian Perspective

open access: yesThe Windsor Yearbook of Access to Justice, 2010
Recognition of the benefits that mediation offers to litigants and to the court and tribunal systems has led to formal recognition and institutionalization of the process in Australia, Canada, the USA and many other countries.
Robyn Carroll, Anita Smith
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Dynamic guardianship of potato landraces by Andean communities and the genebank of the International Potato Center

open access: yesCABI Agriculture and Bioscience, 2021
Potato landraces (Solanum spp.) are not only crucial for food security and sustenance in Andean communities but are also deeply rooted in the local culture.
Sophia Lüttringhaus   +9 more
semanticscholar   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

What are the boundaries of legal guardianship in Alzheimer’s disease? An evidence-based update in the context of the Brazilian Civil Code

open access: yesBrazilian Journal of Psychiatry, 2016
The Brazilian Civil Code, which came into force in 2002, established a functional criterion for guardianship proceedings and introduced the concept of “limited guardianship,” applied to cases in which incapacity to exercise civil rights is partial.
Felipe K. Sudo   +2 more
doaj   +1 more source

Determination of Law Applicable to the Foster Family from a Private International Law Perspective

open access: yesPublic and Private International Law Bulletin, 2022
In the protection of children who cannot be brought up in their biological family, the institution of “foster family,” which is the placement of the child with an unrelated family as alternative care, has been widely accepted.
Ekin Ömeroğlu
doaj   +1 more source

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