Results 41 to 50 of about 1,019 (115)

Dysfunctional DNA repair pathway via defective FANCD2 gene engenders multifarious exomic and transcriptomic effects in Fanconi anemia

Molecular Genetics &Genomic Medicine, Volume 6, Issue 6, Page 1199-1208, November 2018., 2018
NextGen sequencing and analysis of clinically derived Fanconi anemia (FA) cell lines are presented. FA affects only 1 in 130,000 births, but has severe and diverse clinical and genome stability/regulation consequences. We find that the lines have accumulated numerous genetic variants, including high impact mutations, such as deletion of start codons ...
Karthik Raja Velmurugan, Pawel Michalak, Lin Kang, Natalie C. Fonville, Harold R. Garner   +4 more
wiley   +1 more source

Transcriptional Profiling Suggests Extensive Metabolic Rewiring of Human and Mouse Macrophages during Early Interferon Alpha Responses

Mediators of Inflammation, Volume 2018, Issue 1, 2018., 2018
Emerging evidence suggests that cellular metabolism plays a critical role in regulating immune activation. Alterations in energy and lipid and amino acid metabolism have been shown to contribute to type I interferon (IFN) responses in macrophages, but the relationship between metabolic reprogramming and the establishment of early antiviral function ...
Duale Ahmed, Allison Jaworski, David Roy, William Willmore, Ashkan Golshani, Edana Cassol, José C. Rosa   +6 more
wiley   +1 more source

Novel therapeutics for coronary artery disease from genome-wide association study data [PDF]

, 2015
BACKGROUND: Coronary artery disease (CAD), one of the leading causes of death globally, is influenced by both environmental and genetic risk factors. Gene-centric genome-wide association studies (GWAS) involving cases and controls have been remarkably ...
Ballouz, S., Crowley, T. M., George, R. A., Goscinski, A., Grover, M. P., Mohanasundaram, K. A., Sherman, C. D., Wouters, M. A.   +7 more
core   +1 more source

Brief Overview of a Decade of Genome‐Wide Association Studies on Primary Hypertension

International Journal of Endocrinology, Volume 2018, Issue 1, 2018., 2018
Primary hypertension is widely believed to be a complex polygenic disorder with the manifestation influenced by the interactions of genomic and environmental factors making identification of susceptibility genes a major challenge. With major advancement in high‐throughput genotyping technology, genome‐wide association study (GWAS) has become a powerful
Afifah Binti Azam, Elena Aisha Binti Azizan, Raffaele Pezzani   +2 more
wiley   +1 more source

Stimulation of soluble guanylate cyclase exerts antiinflammatory actions in the liver through a VASP/NF-κB/NLRP3 inflammasome circuit [PDF]

, 2021
Soluble guanylate cyclase (sGC) catalyzes the conversion of guanosine triphosphate into cyclic guanosine-3',5'-monophosphate, a key second messenger in cell signaling and tissue homeostasis. It was recently demonstrated that sGC stimulation is associated
Alcaraz-Quiles, José, Casulleras, Mireia, Clària i Enrich, Joan, Duran Güell, Marta, Díaz Lorca, Maria Alba, Flores Costa, Roger, Hall, Katherine, Lozano Salvatella, Juan José, López Vicario, Cristina, Masferrer, Jaime L., Sarno, Renee, Titos Rodríguez, Esther   +11 more
core   +1 more source

Identification of target genes and pathways regulated by miRNA-132, miRNA-182, and miRNA-124 in depression: a bioinformatics analysis

Khyber Medical University Journal
OBJECTIVE: To investigate the associations of miRNA-132, miRNA-182, and miRNA-124 with long-term depression and elucidate their target genes and translational implications utilizing miRabel, a bioinformatics tool.
Shamaila Wadud, Sadia Fatima, Roshan Ali, Rubina Nazli, Zahid Khan, Muhammad Irfan   +5 more
doaj   +1 more source

Towards precision medicine for hypertension: a review of genomic, epigenomic, and microbiomic effects on blood pressure in experimental rat models and humans [PDF]

, 2017
Compelling evidence for the inherited nature of essential hypertension has led to extensive research in rats and humans. Rats have served as the primary model for research on the genetics of hypertension resulting in identification of genomic regions ...
Allbutt TC, Bina Joe, Biron P, Biron P, Bright R, Cook HW, Dublin LI, Dublin LI, Dupont J, Esunge PM, Felts JH, Garrod AE, Garrod AE, Garrod AE, Hamilton M, Hamilton M, Hamilton M, Joe B, Koffler M, Korner PI, Kuijpers MH, Lee YH, Lewis O, Markel’ AL, Matsukawa N, Mo R, Ohno Y, Pickering GW, Pravenec M, Sandosh Padmanabhan, Schlager G, Shear CL, Shiozawa M, Smolarek I, Zhang Y   +34 more
core   +1 more source

The Identification of Key Genes and Pathways in Glioma by Bioinformatics Analysis

Journal of Immunology Research, Volume 2017, Issue 1, 2017., 2017
Glioma is the most common malignant tumor in the central nervous system. This study aims to explore the potential mechanism and identify gene signatures of glioma. The glioma gene expression profile GSE4290 was analyzed for differentially expressed genes (DEGs). Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were applied
Mingfa Liu, Zhennan Xu, Zepeng Du, Bingli Wu, Tao Jin, Ke Xu, Liyan Xu, Enmin Li, Haixiong Xu, Jiaming Liu   +9 more
wiley   +1 more source

Integrative Analysis of miRNA and mRNA Expression Profiles in Calcium Oxalate Nephrolithiasis Rat Model

BioMed Research International, Volume 2017, Issue 1, 2017., 2017
The microRNA (miRNA) expression profiles and their biological functions in calcium oxalate nephrolithiasis remain unclear. In this study, we investigate the miRNA and mRNA expression profiles of kidney tissues in calcium oxalate stone rats. 16 Sprague Dawley rats were divided into control group and stone‐forming group.
Chuangxin Lan, Dong Chen, Xiongfa Liang, Jian Huang, Tao Zeng, Xiaolu Duan, Kang Chen, Yongchang Lai, Dong Yang, Shujue Li, Chonghe Jiang, Wenqi Wu, Sergio Claudio Saccà   +12 more
wiley   +1 more source

Comparative Microarray Analysis of Proliferating and Differentiating Murine ENS Progenitor Cells

Stem Cells International, Volume 2016, Issue 1, 2016., 2016
Postnatal neural progenitor cells of the enteric nervous system are a potential source for future cell replacement therapies of developmental dysplasia like Hirschsprung’s disease. However, little is known about the molecular mechanisms driving the homeostasis and differentiation of this cell pool.
Peter Helmut Neckel, Roland Mohr, Ying Zhang, Bernhard Hirt, Lothar Just, Kodandaramireddy Nalapareddy   +5 more
wiley   +1 more source