Results 91 to 100 of about 4,896,156 (285)

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Evaluating career self-awareness instruments for victims of violence using the Rasch model

BMC Psychology
Background Victims of violence have trauma that often affects career development. A tool is needed to measure a person’s self-perception of self and work environment.
Mamat Supriatna, Dodi Suryana, Megga Nur Anzhali, Amelia Mohd Noor   +3 more
doaj   +1 more source

Flow-Based Assessment of the Impact of an All-Electric Aircraft on European Air Traffic

Aerospace
The consequences of new airspace entrants, such as novel aircraft concepts with innovative propulsion systems, on air traffic management operations need to be carefully identified.
Bekir Yildiz, Peter Förster, Thomas Feuerle, Peter Hecker   +3 more
doaj   +1 more source

Generalized Formulation of Weighted Optimal Guidance Laws with Impact Angle Constraint

, 2013
The purpose of this paper is to investigate the generalized formulation of weighted optimal guidance laws with impact angle constraint. From the generalized formulation, we explicitly find the feasible set of weighting functions that lead to analytical ...
Lee, Chang-Hun, Lee, Jin-Ik, Tahk, Min-Jea   +2 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

REHABILITASI SOSIAL PROGRAM BIMBINGAN RELIGI DALAM MENINGKATKAN KEBERFUNGSIAN SOSIAL ORANG DENGAN GANGGUAN JIWA (ODGJ) DI UPT REHABILITASI SOSIAL BINA LARAS PASURUAN [PDF]

This research aims to identify and explain the social rehabilitation of religious guidance programs in improving the social functioning of people with mental disorders (ODGJ). This research approach is a qualitative, descriptive approach.
Akbar, Adam Putra Riyadi
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source