Results 51 to 60 of about 1,174,895 (219)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Analysis of Correctional Institution Officer Interaction Patterns and Stress During Implementation of Correctional Revitalization in Nusakambangan Indonesian

International Journal of Qualitative Research
The implementation of correctional revitalization is not only related to structural adjustments and security protocols at Super Maximum Security (SMAX), Maximum Security (MAX), and Medium Security (MS) correctional facilities; it may also have an impact ...
Umar Anwar, Imaduddin Hamzah, Vivi Silviani Biafry, Qisthina Aulia   +3 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Trapped in the Digital World: Influence Social Media Addiction Leads to Body Dissatisfaction

Bisma The Journal of Counseling
Social media has evolved into a fundamental component of daily life, influencing nearly every aspect of social interaction, entertainment, and communication.
Asiah, Erwita Ika Violina, Rafael Lisinus Ginting, Kamila Huwaida   +3 more
doaj   +1 more source

Gender-Leadership in the Ivory Tower: A Case Study of Institutions of Higher Education in Taraba State [PDF]

Journal of Modern Psychology
Objective: This study investigated Gender-Leadership in the ivory tower, a survey of higher education institutions in Taraba State, Nigeria.Methods: A descriptive survey design was adopted for the study. A simple random sampling method was used to select
Salama Bako, Abigail Karfe, Godswill Moses   +2 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Iterative Learning Control Combination with Adaptive Sliding Mode Technique for a Hypersonic Vehicle

Xibei Gongye Daxue Xuebao, 2019
Aiming at the complicated nonlinearities, high uncertainties and strong coupling of hypersonic vehicle, a new adaptive iterative learning control method is put forward. The proposed controller combined iterative learning control with sliding mode control.

doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source