Results 61 to 70 of about 1,174,895 (219)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Enhancing counseling teachers’ creativity through Deep Counseling-based Training

Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang
This community service program aimed to enhance the creativity of guidance and counseling teachers through deep counseling-based training. The training was conducted on July 10, 2025, involving 49 guidance and counseling teachers from junior and senior ...
Eka Sakti Yudha, Ahman, Agus Taufiq, Dian Munawarah, Kania Cahyaningtyas, Moch. Dendi Arief Prawira, Muzayyinah Al-Usrah, Yalda Suvita   +7 more
doaj   +1 more source

Sun-Synchronous Orbit Transfer Scheme Based on Solar Sail

Xibei Gongye Daxue Xuebao, 2019
Aiming at the sun-synchronous orbit transfer task of the micro-nano satellite solar sail, the method of combining the weighted control law and the solar sail optimal direction is used for maneuvering the orbit, and a segmentation control strategy is ...

doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The Dynamics of Students’ Independence and Basic Psychological Needs: A Comparative Study of General Boarding Schools and Islamic Boarding Schools

Bisma The Journal of Counseling
The achievement of independence is a crucial developmental task during adolescence; however, boarding school environments often create a dilemma between collective disciplinary control and students’ need for individual autonomy.
Ranni Rahmayanthi, Syarifuddin Dahlan, Diah Utaminingsih, Ratna Widiastuti   +3 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Impact of a mobile career counseling app on career decision-making self-efficacy in students’ transition to higher education

Discover Psychology
Final-year high school students continue to face challenges in transitioning to higher education, with limited time to make crucial career decisions.
Lolang Maria Masi, I Putu Agus Apriliana, Khetye Romelya Saba, Zummy Anselmus Dami   +3 more
doaj   +1 more source