Results 161 to 170 of about 73,176 (262)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Expanding hypertension management through a behavioural counselling perspective: reflections on specialist and non-specialist practice differences

Blood Pressure
Muchammad Syuhada’, Budi Purwoko, Bakhrudin All Habsy, Mochamad Nursalim, Elisabeth Christiana   +4 more
doaj   +1 more source

A scoping review of mental health counseling practices, challenges, and prospects in Ethiopia. [PDF]

Discov Ment Health
Woldemichael A, Wondimu H, Berihun A, Tefera B, Zewdie T.   +4 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Beyond the score: the imperative of comprehensive counseling in polygenic embryo screening. [PDF]

Ann Med Surg (Lond)
Nouman Javed M, Abdul Ghaffar F, Nawaz H, Shahzad O, Zayed A.   +4 more
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

The Role of Medical Counseling in the Use of Contraceptive Methods: A Cross-Sectional Public Health Study. [PDF]

Int J Environ Res Public Health
Alidema FB, Mustafa L, Hasani Alidema A, Havolli M, Abazi F.   +4 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

A comparative study on the outcomes of post-placental intrauterine contraceptive device insertion between preterm and term deliveries: a hospital-based observational study. [PDF]

Contracept Reprod Med
Kumari S, Singh S, Chawla A, Lachyan A.
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source