Results 171 to 180 of about 105,034 (263)

Mental health support in German schools: a cross-sectional survey study of principals on demand vs. provision of support services. [PDF]

Front Public Health
Köhler HE, Bauch J, Rodney-Wolf K, Greiner-Döchert F, Heitz K, Saalbach H, Baumann E, Tucholski N, Schmitz J.   +8 more
europepmc   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Genetic Counselors as Research Leaders: A Pragmatic Pathway to Becoming a Federally Funded Principal Investigator in the United States. [PDF]

J Genet Couns
Zierhut HA, Hetherington S, Mills R.
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Combined counseling based on the Fogg behavior model for managing weight gain in pregnant women: A randomized controlled trial protocol. [PDF]

J Educ Health Promot
Farid F, Omidvar S, Abedi Samakoosh S, Mohsenzadeh-Ledari F, Gholamnia-Shirvani Z, Adib-Rad H, Behmanesh F, Ahangari R, Khafri S.   +8 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Pharmacist-led Chemotherapy Counseling: Impact on Hospital Admissions, Patient Satisfaction, and Cost Avoidance - A Prospective Pre-post Quality Improvement Study. [PDF]

J Res Pharm Pract
Assiri A, Median IA, Alshahrani K, Asiri M, Alsaeed O, Asiri A, Abashar M, Ali M, Alsraeya A.   +8 more
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Nurse-led interventions for cervical cancer patients: A scoping review with an emphasis on East Asian contexts. [PDF]

Belitung Nurs J
Ibitoye OF, Muliira JK, Lazarus ER, Anyango JF, Matua GA.   +4 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source