Results 51 to 60 of about 73,176 (262)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Investigation of the effectiveness of parent-child interaction therapy on adjustment and behavioral problems in children with subthreshold autism

Frontiers in Psychology
BackgroundAutism Spectrum Disorder (ASD) is an increasingly prevalent neurodevelopmental disorder. However, the number of children who exhibit subthreshold levels of ASD symptoms, significant enough to experience functional and adaptive difficulties, is ...
İsmail Seçer, Sümeyye Ulaş, Eda Tatlı, Fatmanur Çimen, Burcu Bülbül, Beyzanur Tosunoğlu   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Self-esteem, Social Support, Personality and Psychological Well Being of Junior High School Student

Jurnal Pendidikan Humaniora, 2018
: The aims of this study was to understand how the relationship between self-esteem, social support, extraversion personality, agreeableness personality, conscientiousness personality, neuroticism personality, openness personality, and psychological well-
Mufied Fauziah, Dany Moenindyah Handarini, Muslihati Muslihati   +2 more
doaj  

The Implementation of Problem-Based Learning to Overcome Communication Barriers in Public Speaking in the Counseling Process

Jurnal Ilmiah Bimbingan Konseling Undiksha
Communication and public speaking skills are essential for counselors to establish effective therapeutic relationships. However, communication barriers often reduce the quality of counseling. This study aims to analyze the effectiveness of Problem-Based
Azba Novanda Fasha, Henny Indeswari, Khairul Bariyyah   +2 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Evaluating career self-awareness instruments for victims of violence using the Rasch model

BMC Psychology
Background Victims of violence have trauma that often affects career development. A tool is needed to measure a person’s self-perception of self and work environment.
Mamat Supriatna, Dodi Suryana, Megga Nur Anzhali, Amelia Mohd Noor   +3 more
doaj   +1 more source

School Burnout as a Mediator Between Father-Love Absence and Meaning in Life Among Indonesian Adolescents

Journal of EST (Educational Science And Technology)
. Adolescents face increasing family and academic demands that may compromise their psychological well-being and sense of meaning in life. Father-love absence has been identified as a significant psychological risk factor undermining adolescents' well ...
Mufied Fauziah, Dody Hartanto, Prima Suci Rohmadheny, Aprilia Setyowati, Zerlinda Aurora Saputri   +4 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source