Results 81 to 90 of about 3,059,962 (299)
Using genetic selection, Guide Dogs for the Blind (GDB) has reduced the incidence rate of canine hip dysplasia (CHD). However, given that CHD is polygenic and multifactorial, environmental factors may impact the expression of this developmental condition.
Lynna C. Feng+3 more
doaj +1 more source
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke+2 more
wiley +1 more source
Early warning of geo-hazards based on meteorological factors in China began in 2003, and early warning informations are issued to the public every year during the flood season to alert the public to guard against geo-hazards such as landslides, debris ...
Huiqing WANG+5 more
doaj +1 more source
Covariant Lagrangian Methods of Relativistic Plasma Theory [PDF]
We obtain a covariant decomposition of the motion of a relativistic charged particle into parallel motion and perpendicular gyration, and transform to guiding-center coordinates using Lie transforms. The natural guiding-center Poisson bracket structure and Hamiltonian are derived. The guiding-center equations of motion are presented to one order higher
arxiv
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek+15 more
wiley +1 more source
A user's guide: Completed power operations for Morava $E$-theory [PDF]
The user's guide provides a behind-the-scenes look at the paper of that title.
arxiv
AN ANATOMICAL GUIDE TO EXPERIMENTAL RESEARCHES ON THE RABBITʼS BRAIN [PDF]
NULL AUTHOR_ID
openalex +1 more source
Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner+7 more
wiley +1 more source
Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley +1 more source