Results 81 to 90 of about 2,082,427 (238)
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Training as mobility and orientation instructors, 1979 -- 02
, 1979 Students from National Guide Dog Mobility Training Centre, Kew.
Swinburne Technical College
core
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Utah Prairie Dog Habitat Evaluation Guide [PDF]
, 2007 The Utah prairie dog (Cynomys parvidens) (UPD) is listed as a threatened species under the Endangered Species Act (ESA) and exists only in southwestern Utah.
Environmental Defense +1 more
core +1 more source
Austral Journal of Veterinary SciencesSpinal instability in a 12-year-old Maltese with T11-12 subluxation presenting with neurological symptoms, including hindlimb paraplegia, was treated using double-pin and polymethyl methacrylate (PMMA) fixation. Postoperatively, neurological deficits and
Kangwoo Yi, Ingoo Kwak, Suyoung Heo
doaj +1 more source
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
Training as mobility and orientation instructors, 1979 -- 04
, 1979 Students from National Guide Dog Mobility Training Centre, Kew. Training as mobility and orientation instructors for blind or partially sighted people.
Swinburne Technical College
core
A cross-sectional study of factors associated with dog ownership in Tanzania [PDF]
, 2008 Background: Mass vaccination of owned domestic dogs is crucial for the control of rabies in sub-Saharan Africa. Knowledge of the proportion of households which own dogs, and of the factors associated with dog ownership, is important for the planning and ...
M Karen Laurenson +25 more
core +1 more source
Austral Journal of Veterinary SciencesThis case report describes the application of a patient-specific saw guide (PSSG) for patellar groove replacement (PGR) in a dog with severe medial patellar luxation, stifle osteoarthritis, and minor femoral varus deformity.
Jongchan Ko +3 more
doaj +1 more source