Results 201 to 210 of about 570,529 (349)

Guide to the Nomenclature of Kinetoplastid RNA Editing: A Proposal [PDF]

, 2009
Larry Simpson, Ruslan Aphasizhev, Julius Lukeš, Jorge Cruz‐Reyes   +3 more
openalex   +1 more source

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

Molecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas, Konstantinos Voutetakis, Vivian Kosmidou, Spyridon Tsikalakis, Spyridon Roditis, Konstantinos Pateas, Ryangguk Kim, Kymberleigh Pagel, Stephan Wolf, Gregor Warsow, Antonia Dimitrakopoulou‐Strauss, Georgios N. Zografos, Alexander Pintzas, Johannes Betge, Olga Papadodima, Stefan Wiemann   +15 more
wiley   +1 more source

Antisense pairing and SNORD13 structure guide RNA cytidine acetylation [PDF]

RNA, 2022
Thalalla Gamage S, Bortolin-Cavaillé M, Link C, Bryson K, Sas-Chen A, Schwartz S, Cavaillé J, Meier JL.   +7 more
europepmc   +2 more sources

Small RNAs in the animal gonad: Guarding genomes and guiding development [PDF]

, 2010
Nelson C. Lau
openalex   +1 more source

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

Spacer Fidelity Assessments of Guide RNA by Top-Down Mass Spectrometry. [PDF]

ACS Cent Sci, 2023
Macias LA, Garcia SP, Back KM, Wu Y, Johnson GH, Kathiresan S, Bellinger AM, Rohde E, Freitas MA, Madsen JA.   +9 more
europepmc   +1 more source

OB-fold domain of KREPA4 mediates high-affinity interaction with guide RNA and possesses annealing activity [PDF]

, 2010
Smriti Kala, Reza Salavati
openalex   +1 more source

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

Molecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh, Amelia Martinez Villarreal, Philippe Lefrançois, Jennifer Gantchev, Sriraam Sivachandran, Samy Abou Setah, Ivan V. Litvinov   +6 more
wiley   +1 more source

RNA-guided Nucleotide Modification of Ribosomal and Other RNAs [PDF]

Journal of Biological Chemistry, 2003
Maurille J. Fournier, Wayne A. Decatur
openaire   +2 more sources

Structural basis for CRISPR RNA-guided DNA recognition by Cascade [PDF]

, 2011
Matthijs M. Jore, Magnus Lundgren, Esther van Duijn, Jelle B. Bultema, Edze R. Westra, Sakharam Waghmare, Blake Wiedenheft, Ümit Pul, Reinhild Wurm, Rolf Wagner, Marieke R. Beijer, Arjan Barendregt, Kaihong Zhou, Ambrosius P. Snijders, Mark J. Dickman, Jennifer A. Doudna, Egbert J. Boekema, Albert J. R. Heck, John van der Oost, Stan J. J. Brouns   +19 more
openalex   +1 more source