Results 221 to 230 of about 570,529 (349)

Efficient prioritization of CRISPR screen hits by accounting for targeting efficiency of guide RNA. [PDF]

BMC Biol, 2023
Park BS, Jeon H, Chi SG, Kim T.
europepmc   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Genome-wide CRISPR guide RNA design and specificity analysis with GuideScan2. [PDF]

Genome Biol
Schmidt H, Zhang M, Chakarov D, Bansal V, Mourelatos H, Sánchez-Rivera FJ, Lowe SW, Ventura A, Leslie CS, Pritykin Y.   +9 more
europepmc   +1 more source

Regulation of the CRISPR-Cas12a system by methylation and demethylation of guide RNA. [PDF]

Chem Sci, 2023
Hu Z, Sun A, Yang J, Naz G, Sun G, Li Z, Gogo Liu JJ, Zhang S, Zhang X.   +8 more
europepmc   +1 more source

Regulated RNA rewriting: Modelling RNA editing with guided insertion

, 2007
Franziska Biegler, Michael J. Burrell, Mark Daley   +2 more
openalex   +1 more source

Highly efficient gene knockout in mice and zebrafish with RNA-guided endonucleases [PDF]

, 2013
Young Hoon Sung, Jong Min Kim, Hyun-Taek Kim, Jaehoon Lee, Jisun Jeon, Young Jin, Jung-Hwa Choi, Young Ho Ban, Sang‐Jun Ha, Cheol‐Hee Kim, Han‐Woong Lee, Jin‐Soo Kim   +11 more
openalex   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

In Vitro Reconstitution of an Escherichia coli RNA-guided Immune System Reveals Unidirectional, ATP-dependent Degradation of DNA Target [PDF]

, 2013
Sabin Mulepati, Scott Bailey
openalex   +1 more source

The roles and applications of extracellular vesicles in cancer

Molecular Oncology, EarlyView.
Extracellular vesicles (EVs) are minute versions of cells limited by a lipid bilayer containing cytoplasm from the cell that releases them, but without a nucleus and thus unable to self‐reproduce. EVs contain multiple molecules (proteins, lipids, glycans, and nucleic acids) they can induce complex responses in cells.
Clotilde Théry, Daniel Louvard
wiley   +1 more source

A molecular proximity sensor based on an engineered, dual-component guide RNA. [PDF]

Elife
Choi J, Chen W, Liao H, Li X, Shendure J.   +4 more
europepmc   +1 more source