Results 291 to 300 of about 570,529 (349)

CINs of the cytoplasm: dissecting dsRNA signaling in chromosomal instability

Molecular Oncology, EarlyView.
Micronuclei, formed during cell division in chromosomal instability settings, rupture and lead to the accumulation of immunogenic double‐stranded RNA in the cytoplasm, activating MAVS‐dependent interferon signaling and innate antitumor immunity.
Aglaia Skolariki, Rose L. Jady‐Clark, Eileen E. Parkes   +2 more
wiley   +1 more source

DNA interrogation by the CRISPR RNA-guided endonuclease Cas9

, 2014
Samuel H. Sternberg, Sy Redding, Martin Jínek, Eric C. Greene, Jennifer A. Doudna   +4 more
openalex   +3 more sources

SynDesign: web-based prime editing guide RNA design and evaluation tool for saturation genome editing. [PDF]

Nucleic Acids Res
Park J, Yu G, Seo SY, Yang J, Kim HH.
europepmc   +1 more source

Faculty Opinions recommendation of Small CRISPR RNAs guide antiviral defense in prokaryotes.

, 2013
Luciano A. Marraffini
openalex   +2 more sources

Guide RNAs in RNA editing. [PDF]

, 2005
Golden, Daniel E
core   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

CRISPR/Pepper-tDeg: A Live Imaging System Enables Non-Repetitive Genomic Locus Analysis with One Single-Guide RNA. [PDF]

Adv Sci (Weinh)
Chen M, Huang X, Shi Y, Wang W, Huang Z, Tong Y, Zou X, Xu Y, Dai Z.   +8 more
europepmc   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Compact CRISPR genetic screens enabled by improved guide RNA library cloning. [PDF]

Genome Biol
Heo SJ, Enriquez LD, Federman S, Chang AY, Mace R, Shevade K, Nguyen P, Litterman AJ, Shafer S, Przybyla L, Chow ED.   +10 more
europepmc   +1 more source

Faculty Opinions recommendation of DNA targeting specificity of RNA-guided Cas9 nucleases.

, 2013
Blake Wiedenheft
openalex   +2 more sources