Results 271 to 280 of about 323,472 (305)
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Journal of Theoretical Biology, 2007
We propose molecular models for homologous DNA recombination events that are guided by either double-stranded RNA (dsRNA) or single-stranded RNA (ssRNA) templates. The models are applied to explain DNA rearrangements in some groups of ciliates, such as Stylonychia or Oxytricha, where extensive gene rearrangement occurs during differentiation of a ...
Angeleska, Angela +3 more
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We propose molecular models for homologous DNA recombination events that are guided by either double-stranded RNA (dsRNA) or single-stranded RNA (ssRNA) templates. The models are applied to explain DNA rearrangements in some groups of ciliates, such as Stylonychia or Oxytricha, where extensive gene rearrangement occurs during differentiation of a ...
Angeleska, Angela +3 more
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The principles of guiding by RNA: chimeric RNA–protein enzymes
Nature Reviews Genetics, 2006The non-protein-coding transcriptional output of the cell is far greater than previously thought. Although the functions, if any, of the vast majority of these RNA transcripts remain elusive, out of those for which functions have already been established, most act as RNA guides for protein enzymes.
Alexander, Hüttenhofer +1 more
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Trends in Genetics, 1999
Cold Spring Harbor Laboratory Press, 1999. $129.00 (709 + xxv pages)ISBN 0 87969 561 7This is a new edition of a multi-author work whose first edition appeared in 1993. To quote from Crick’s foreword to the first edition (reprinted in this edition), ‘the “RNA World” originally referred to a hypothetical time in the evolution of earthly life when there ...
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Cold Spring Harbor Laboratory Press, 1999. $129.00 (709 + xxv pages)ISBN 0 87969 561 7This is a new edition of a multi-author work whose first edition appeared in 1993. To quote from Crick’s foreword to the first edition (reprinted in this edition), ‘the “RNA World” originally referred to a hypothetical time in the evolution of earthly life when there ...
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External Guide Sequences for an RNA Enzyme
Science, 1990Ribonuclease P (RNase P) from Escherichia coli or its catalytic RNA subunit can efficiently cleave small RNA substrates that lack the conserved features of natural substrates of RNase P if an additional small RNA is also present.
A C, Forster, S, Altman
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RNA Editing: RNA duplexes guide base conversions
Current Biology, 1994Recent evidence strengthens the case that editing of mRNAs encoding glutamate receptors subunits occurs by a mechanism in which the RNA editing substrate has a double-stranded conformation.
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Characterization of Cas9–Guide RNA Orthologs
Cold Spring Harbor Protocols, 2016In light of the multitude of new Cas9-mediated functionalities, the ability to carry out multiple Cas9-enabled processes simultaneously and in a single cell is becoming increasingly valuable. Accomplishing this aim requires a set of Cas9–guide RNA (gRNA) pairings that are functionally independent and insulated from one another.
Jonathan L. Braff +3 more
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Small Nucleolar RNAs Guide Ribosomal RNA Methylation
Science, 1996Two recent reports, one in Cell and one in the Journal of Molecular Biology , show that the newly described small nucleolar RNAs control the site of methylation of the ribosomal RNA (rRNA). Tollervey explains how these small RNAs accomplish this targeting and discusses the possible role of ...
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The Cmr complex: an RNA-guided endoribonuclease
Biochemical Society Transactions, 2013The CRISPR (clustered regularly interspaced short palindromic repeats)–Cas (CRISPR-associated) system protects prokaryotes from infection by viruses and other potential genome invaders. This system represents an inheritable and adaptable immune system that is mediated by large ribonucleoprotein complexes, the CRISPR–Cas effector complexes.
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Strategies for RNA-Guided DNA Recombination
2009We present a model for homologous DNA recombination events guided by double-stranded RNA (dsRNA) templates, and apply this model to DNA rearrangements in some groups of ciliates, such as Stylonychia or Oxytricha. In these organisms, differentiation of a somatic macronucleus from a germline micronucleus involves extensive gene rearrangement, which can ...
Angela Angeleska +3 more
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Guide RNAs and guide RNA genes in the cryptobiid kinetoplastid protozoan, Trypanoplasma borreli.
RNA (New York, N.Y.), 1996Trypanoplasma borreli belongs to the bodonid/cryptobiid group of kinetoplastid protozoa, which represents a sister group to the trypanosomatids. RNA transcripts from several mitochondrial genes in this organism undergo the trypanosomatid type of uridine addition/deletion RNA editing.
S, Yasuhira, L, Simpson
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