Results 1 to 10 of about 22,098 (274)

CRISPR/Cas13-Based Anti-RNA Viral Approaches

RNA viruses pose significant threats to global health, causing diseases such as COVID-19, HIV/AIDS, influenza, and dengue. These viruses are characterized by high mutation rates, rapid evolution, and the ability to evade traditional antiviral therapies ...
Toischer, Karl, Hasenfuß, Gerd, Xiaoying Tan, Juncong Li, Li, Juncong, Wu, Jingjing, Xingbo Xu, Tan, Xiaoying, Gerd Hasenfuß, Xu, Xingbo, Jingjing Wu, Baolong Cui, Karl Toischer, Cui, Baolong   +13 more
core   +1 more source

Testing multiplexed anti-ASFV CRISPR-Cas9 in reducing African swine fever virus

Microbiology Spectrum
African swine fever (ASF) is a highly fatal viral disease that poses a significant threat to domestic pigs and wild boars globally. In our study, we aimed to explore the potential of a multiplexed CRISPR-Cas system in suppressing ASFV replication and ...
Zezhong Zheng, Lei Xu, Yangbin Gao, Hongwei Dou, Yixuan Zhou, Xu Feng, Xiangjun He, Zhen Tian, Lingling Song, Guolong Mo, Jiapan Hu, Hongye Zhao, Hongjiang Wei, George M. Church, Luhan Yang   +14 more
doaj   +1 more source

CRISPRoffT: Comprehensive Database of CRISPR/Cas Off-Targets

The CRISPR (clustered regularly interspaced short palindromic repeats)/Cas (CRISPR-associated protein) programmable nuclease system continues to evolve, with in vivo therapeutic gene editing increasingly applied in clinical settings.
Zhou, Xiaobo, Wang, Aoqi, Wen, Jianguo, Song, Qianqian, Liu, Xiaona, Kim, Pora, Wang, Grant   +6 more
core   +1 more source

Unveiling the invisible genomic dynamics

Experimental and Molecular Medicine
CRISPR-based imaging technologies have emerged as powerful tools for visualizing specific genomic loci, providing groundbreaking insights into chromatin structure and dynamics. Here, in this Review, we discuss the development and recent advances in these
Jiwoong Kwon, Yeji Park, Taekjip Ha
doaj   +1 more source

Multilayer regulation of CRISPR systems: integrating anti-CRISPR proteins, CRISPRi/a, and quorum sensing networks. [PDF]

Front Cell Infect Microbiol
Shan C, Liu C, Jin C, Tian D.
europepmc   +1 more source

CRISPR and Fanzor in sickle cell disease: current progress and future prospects. [PDF]

Front Genome Ed
Alhumoudi AY, Alotaibi AG, Alosaimi NF, Alshalani A, Alqahtani SM, Alsaab SM, Almutiri BJ, Albariqi MMH.   +7 more
europepmc   +1 more source

CRISPR Diagnostics, in Your Pocket. [PDF]

J Med Internet Res
Dominy C.
europepmc   +1 more source

CasCADE: Cas<i>-C</i>RISPR Automated Design and Evaluation for targeted gRNA detection assays. [PDF]

Microbiol Spectr
Price C, Lucas JL, Davis P, Smith C, Jarvis E, Fiore J, Russell JA, Winegar R.   +7 more
europepmc   +1 more source

Advances in CRISPR Plant Applications. [PDF]

Int J Mol Sci
Jing L, Roy D, Kalischuk M.
europepmc   +1 more source

Applications and Challenges of CRISPR-Cas Technology for the Detection of Antimicrobial Resistance Genes. [PDF]

Infect Drug Resist
Tang W, Yang N, Shi M.
europepmc   +1 more source