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Chimeric DNA–RNA Guide RNA Designs
2020CRISPR-associated nuclease (Cas) has been widely applied to modify the genomes of various cell types. As RNA-guided endonucleases, Cas enzymes can target different genomic sequences simply by changing the guide sequence of the CRISPR RNA (crRNA) or single guide RNA (sgRNA).
Shuhan, Lu, Ying, Zhang, Hao, Yin
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Science, 2001
In diverse organisms, small RNAs derived from cleavage of double-stranded RNA can trigger epigenetic gene silencing in the cytoplasm and at the genome level. Small RNAs can guide posttranscriptional degradation of complementary messenger RNAs and, in plants, transcriptional gene silencing by methylation of homologous DNA sequences.
M, Matzke, A J, Matzke, J M, Kooter
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In diverse organisms, small RNAs derived from cleavage of double-stranded RNA can trigger epigenetic gene silencing in the cytoplasm and at the genome level. Small RNAs can guide posttranscriptional degradation of complementary messenger RNAs and, in plants, transcriptional gene silencing by methylation of homologous DNA sequences.
M, Matzke, A J, Matzke, J M, Kooter
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RNA-Guided RNA Modifications: Biogenesis, Functions, and Applications
Accounts of Chemical Research, 2023Post-transcriptional modifications are ubiquitous in both protein-coding and noncoding RNAs (ncRNAs), playing crucial functional roles in diverse biological processes across all kingdoms of life. These RNA modifications can be achieved through two distinct mechanisms: RNA-independent and RNA-guided (also known as RNA-dependent).
Bin Li, Lianghu Qu, Jianhua Yang
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Journal of Theoretical Biology, 2007
We propose molecular models for homologous DNA recombination events that are guided by either double-stranded RNA (dsRNA) or single-stranded RNA (ssRNA) templates. The models are applied to explain DNA rearrangements in some groups of ciliates, such as Stylonychia or Oxytricha, where extensive gene rearrangement occurs during differentiation of a ...
Angeleska, Angela +3 more
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We propose molecular models for homologous DNA recombination events that are guided by either double-stranded RNA (dsRNA) or single-stranded RNA (ssRNA) templates. The models are applied to explain DNA rearrangements in some groups of ciliates, such as Stylonychia or Oxytricha, where extensive gene rearrangement occurs during differentiation of a ...
Angeleska, Angela +3 more
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The principles of guiding by RNA: chimeric RNA–protein enzymes
Nature Reviews Genetics, 2006The non-protein-coding transcriptional output of the cell is far greater than previously thought. Although the functions, if any, of the vast majority of these RNA transcripts remain elusive, out of those for which functions have already been established, most act as RNA guides for protein enzymes.
Alexander, Hüttenhofer +1 more
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Trends in Genetics, 1999
Cold Spring Harbor Laboratory Press, 1999. $129.00 (709 + xxv pages)ISBN 0 87969 561 7This is a new edition of a multi-author work whose first edition appeared in 1993. To quote from Crick’s foreword to the first edition (reprinted in this edition), ‘the “RNA World” originally referred to a hypothetical time in the evolution of earthly life when there ...
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Cold Spring Harbor Laboratory Press, 1999. $129.00 (709 + xxv pages)ISBN 0 87969 561 7This is a new edition of a multi-author work whose first edition appeared in 1993. To quote from Crick’s foreword to the first edition (reprinted in this edition), ‘the “RNA World” originally referred to a hypothetical time in the evolution of earthly life when there ...
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RNA Editing: RNA duplexes guide base conversions
Current Biology, 1994Recent evidence strengthens the case that editing of mRNAs encoding glutamate receptors subunits occurs by a mechanism in which the RNA editing substrate has a double-stranded conformation.
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Small Nucleolar RNAs Guide Ribosomal RNA Methylation
Science, 1996Two recent reports, one in Cell and one in the Journal of Molecular Biology , show that the newly described small nucleolar RNAs control the site of methylation of the ribosomal RNA (rRNA). Tollervey explains how these small RNAs accomplish this targeting and discusses the possible role of ...
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Influence of N1-Methylpseudouridine in Guide RNAs on CRISPR/Cas9 Activity
International Journal of Molecular Sciences, 2023Grigory Stepanov, Daria Prokhorova
exaly