Results 191 to 200 of about 1,518,022 (349)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Deep Caries Management: EFCD-ESE-ORCA S3-Level Clinical Practice Guideline. [PDF]

Caries Res
Schwendicke F, Kosan E, Banerjee A, Baysan A, Bjørndal L, Ceballos L, Duncan HF, Herbst S, Neuhaus KW, O Apos Connell AC, Paris S, Dujic H.   +11 more
europepmc   +2 more sources

Promise and pitfalls of AI chatbots in complex decision-making for thyroid nodules and papillary thyroid cancer. [PDF]

Eur Thyroid J
Effraimidis G, Kasotas A, Varsami S, Sazakli E, Karapanou O, Saltiki K, Michalaki M.   +6 more
europepmc   +1 more source

Guidelines

The Journal of ExtraCorporeal Technology, 2016
openaire   +2 more sources

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Guidelines are merely guidelines

Indian Journal of Psychiatry
Chittaranjan Andrade, Sujit Sarkhel
openaire   +3 more sources

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Assessing Clinical Inertia on Implementing Clinical Guideline Recommendations in Patients with Type 2 Diabetes: A Clinician Survey Study. [PDF]

Diabetes Metab Syndr Obes
Stephenson JJ, Witkowski N, Smith JL, Wong AC, Bengtson LGS, Willey VJ.   +5 more
europepmc   +1 more source

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha, Bishwas Mandal, Vishal Mandal, Asis Shrestha, Amir Babu Shrestha   +4 more
wiley   +1 more source

The European Respiratory Society guideline for management of adult bronchiectasis: clinical summary. [PDF]

Breathe (Sheff)
Chalmers JD, Sibila O, Cortina BH, Long MB, Chotirmall SH, Aliberti S.   +5 more
europepmc   +1 more source