Results 101 to 110 of about 276,892 (360)

Barriers to Pediatric Sickle Cell Disease Guideline Recommendations. [PDF]

, 2019
National guidelines recommend that providers counsel all patients with sickle cell anemia about hydroxyurea (HU) therapy and screen children with sickle cell anemia annually for the risk of stroke with transcranial Doppler (TCD).
Bardach, Naomi S, Cabana, Michael D, Kanter, Julie, Marsh, Anne M, Rowland, Michael, Stemmler, Peggy, Treadwell, Marsha J   +6 more
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The GUIDES checklist: development of a tool to improve the successful use of guideline-based computerised clinical decision support [PDF]

, 2018
Background: Computerised decision support (CDS) based on trustworthy clinical guidelines is a key component of a learning healthcare system. Research shows that the effectiveness of CDS is mixed.
Aertgeerts, Bert, Flottorp, Signe, GUIDES expert panel,, Kortteisto, Tiina, Kunnamo, Ilkka, Roshanov, Pavel, Van de Velde, Stijn, Vandvik, Per Olav   +7 more
core   +6 more sources

Adherence level of Health care Providers to first visit antenatal care guideline and its effect on perinatal outcome in Tigray public Health institutions, 2017/18: Cohort study [PDF]

, 2020
Abera Haftu Melkamu, Tesfay Adhena Hailu, Brhane G her G micheal, Hadgay Hagos Adhanu, Mhiret-AB Mehari Reda, Assefa Kebede, Tsige Araya Hailu, Hailemaryam Berhe Kahsa, Haftu Berhe Gebru, Alemayehu Bayray Kahsay   +9 more
openalex   +1 more source

Guideline Adherence and Registry Recruitment of Congenital Primary Hypothyroidism: Data from the German Registry for Congenital Hypothyroidism (HypoDok) [PDF]

, 2021
Julia Thomann, Sascha R. Tittel, Egbert Voß, Rudolf Oeverink, Katja Palm, Susanne Fricke‐Otto, Klaus Kapelari, Reinhard W. Holl, Joachim Woelfle, Markus Bettendorf   +9 more
openalex   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Level of adherence to prescribed exercise in spondyloarthritis and factors affecting this adherence: a systematic review [PDF]

, 2019
Adherence is a primary determinant of the effectiveness of any intervention. Exercise is considered essential in the management of spondyloarthritis (SpA); however, the overall adherence to exercise programmes and factors affecting adherence are unknown.
Coulter, EH, McDonald, DA, McDonald, MT, Paul, L, Siebert, S   +4 more
core   +2 more sources

Structured implementation of digital, systematically updated guideline recommendations for enhanced adherence in schizophrenia (SISYPHOS)—protocol of a cluster-randomized trial [PDF]

, 2022
Carolin Lorenz, Gabriele Gaigl, Duygu Güler, Theresa Halms, Naiiri Khorikian–Ghazari, Astrid Röh, Marco Schneider, Elias Wagner, Thomas Schneider-Axmann, Angelika Kapfhammer, Marisa Flick, Charline Pielenz, Eva Salveridou‐Hof, Peter Falkai, Wolfgang Gäebel, Alkomiet Hasan, Stefan Leucht   +16 more
openalex   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Chronic Pain Management With Opioids: An Assessment of Alaska Nurse Practitioner Practices [PDF]

, 2016
Presented to the Faculty of the University of Alaska Anchorage in Partial Fulfillment of the Requirements for the Degree of MASTER OF SCIENCEThe purpose of this project was to determine chronic opioid pain management practices of Alaskan Nurse ...
Klein, Stephanie
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