Results 91 to 100 of about 276,892 (360)

Adherence of cardiologist physicians to the American heart association guideline in approach to risk factors of cardiovascular diseases: An experience from a teaching hospital

ARYA Atherosclerosis, 2019
BACKGROUND: Cardiovascular disease (CVD) is the leading cause of death globally and has enormous costs for healthcare systems. This disease has a strong association with lifestyle behaviors.
Zarrintaj Hosseinzadeh-Shanjani, Soodabeh Hoveidamanesh, Mozhdeh Ramezani, Farnoush Davoudi, Marzieh Nojomi   +4 more
doaj   +1 more source

Adherence to guideline recommendations in the management of upper tract urothelial carcinoma: an analysis of the CROES–UTUC registry [PDF]

, 2022
Joyce Baard, Shahrokh F. Shariat, Morgan Rouprêt, Takashi Yoshida, Alberto Saita, Iliya Saltirov, Javier Revilla Burgos, Orçun Çelik, Jean de la Rosette, Pilar Laguna   +9 more
openalex   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Impact of implementation of the national institute for health and clinical excellence (NICE) head injury guideline in a tertiary care center emergency department: A pre and post-intervention study.

PLoS ONE, 2021
IntroductionHead injury, a common presentation to the emergency department (ED), is a substantial problem in developing countries like Nepal. The current national institute for health and clinical excellence (NICE) guideline revised in January 2014 ...
Pratisha Pradhan, Alok Pradhan, Anmol Purna Shrestha, Abha Shrestha, Ram Chandra Paudel, Roshana Shrestha   +5 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Medicines adherence: Involving patients in decisions about prescribed medicines and supporting adherence [PDF]

, 2009
It is thought that between a third and a half of all medicines1 There are many causes of non-adherence but they fall into two overlapping categories: intentional and unintentional.
Benson, J., Blair, J., Bowser, A., Calvert, N., Clyne, W., Crome, P., Haddad, P., Hemingway, S., Horne, R., Johnson, S., Kelly, S., Kuntze, S., National Collaborating Centre for Primary Care, Neilson, J., Nunes, V., O'Flynn, N., Packam, B., Patel, Mahendra, Smithson, H., Steel, J.   +19 more
core  

Adequacy of Depression Treatment in Spouses of Cancer Survivors: Findings From a Nationally Representative US Survey [PDF]

, 2018
Background Recent research suggests that mental health problems in spouses of cancer survivors are associated with worse mental health in the survivors themselves.
DuBenske, Lori, Keller, Abiola O., Litzelman, Kristin, Tevaarwerk, Amye   +3 more
core   +2 more sources

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Pilot and feasibility trials in traditional Chinese medicine: a literature review of current practice

Pilot and Feasibility Studies, 2020
Background The guidelines for pilot and feasibility studies were published in 2016. Little is known about the guideline adherence of TCM (traditional Chinese medicine) pilot trials or whether the guidelines can significantly enhance the quality of ...
Guowei Li, Darong Wu, Xuejiao Chen, Jie Zeng, Ziyi Li, Lehana Thabane   +5 more
doaj   +1 more source