Results 41 to 50 of about 4,211,568 (311)

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Guidelines for the authors [PDF]

, 2017
Publication of English-language versions of the volumes of the yearly Studia Ceranea. Journal of the Waldemar Ceran Research Centre for the History and Culture of the Mediterranean Area and South-East Europe financed through contract no. 501/1/P-DUN/2017
Kawecka, Agata, Kompa, Andrzej, Leszka, Mirosław J., Marinow, Kirił, Minczew, Georgi, Petrov, Ivan, Skowronek, Małgorzata   +6 more
core  

Taking flight:Trust, ethics, and the comfort of strangers [PDF]

, 2012
This article explores the themes of trust and ethical conduct in social research, with particular attention to the trust that can develop between the members of a research team as well as between researchers and the researched.
MacAllister, James, MacLeod, Gale, Pirrie, Anne   +2 more
core   +1 more source

Do emergency medicine journals promote trial registration and adherence to reporting guidelines? A survey of “Instructions for Authors”

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2016
BackgroundThe aim of this study was to evaluate the current state of two publication practices, reporting guidelines requirements and clinical trial registration requirements, by analyzing the “Instructions for Authors” of emergency medicine journals ...
M. Sims, Nolan Henning, C. Wayant, M. Vassar   +3 more
semanticscholar   +1 more source

WFH Guidelines for the Management of Hemophilia, 3rd edition

Haemophilia, 2020
Alok Srivastava 1 | Elena Santagostino 2 | Alison Dougall 3 | Steve Kitchen 4 | Megan Sutherland 5 | Steven W. Pipe 6 | Manuel Carcao 7 | Johnny Mahlangu 8 | Margaret V. Ragni 9 | Jerzy Windyga 10 | Adolfo Llinás 11 | Nicholas J. Goddard 12 | Richa Mohan
A. Srivastava, E. Santagostino, A. Dougall, S. Kitchen, M. Sutherland, S. Pipe, M. Carcao, J. Mahlangu, M. Ragni, J. Windyga, A. Llinás, N. Goddard, Richa Mohan, P. Poonnoose, B. Feldman, Sandra Zelman Lewis, H. Berg, Glenn F. Pierce   +17 more
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

JNCHC Front & Back Matter, Vol. 20, No 2, Fall/Winter 2019 [PDF]

, 2019
Cover Masthead Contents Call for Papers, Editorial Policy, & Submission Guidelines Dedication -- Art L.

core   +1 more source

Representation of Women Authors in International Heart Failure Guidelines and Contemporary Clinical Trials

Circulation: Heart Failure, 2020
Supplemental Digital Content is available in the text. Background: Gender disparities in authorship of heart failure (HF) guideline citations and clinical trials have not been examined. Methods: We identified authors of publications referenced in Class I
N. Reza, A. Tahhan, N. Mahmud, E. DeFilippis, Alaaeddin Alrohaibani, M. Vaduganathan, S. Greene, Annie H. Ho, G. Fonarow, J. Butler, C. O'connor, M. Fiuzat, O. Vardeny, I. Piña, J. Lindenfeld, M. Jessup   +15 more
semanticscholar   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source