Results 91 to 100 of about 135,352 (264)

Uterine choriocarcinoma associated with ovarian cysts in a Cavia porcellus: a clinical case

Frontiers in Veterinary Science
A 3. 5-year-old female guinea pig was presented for suspected hematuria. Hematology, serum biochemistry, urinalysis, and fecal examination were within normal limits; however, diagnostic imaging revealed multiple ovarian cysts and a uterine mass without ...
Alessandro Vetere, Martina Gavezzoli, Viola Bigazzi, Melania Di Pentima, Federico Armando, Martina Fumeo, Benedetta Passeri, Francesco Di Ianni   +7 more
doaj   +1 more source

An Experimental Study on the Protective Effect of Memantine in Noise‐Induced Hearing Loss

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective This study examined the potential protective effects of memantine, an N‐methyl‐D‐aspartate (NMDA) receptor antagonist, against acoustic trauma (AT) in guinea pigs, using electrophysiological and histopathological analyses. Methods Thirty guinea pigs with normal hearing were divided into six groups (n = 5 per group): Group 1 (control),
Begüm Arda, Selis Gülseven Güven, Erdoğan Bulut, Murat Arslan, Özlem Tuğce Çilingir‐Kaya, Abdullah Taş, Recep Yağız   +6 more
wiley   +1 more source

Soil and microbial responses to wild ungulate trampling depend more on ecosystem type than trampling severity

Functional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Physical trampling is a ubiquitous activity of walking vertebrates, but is poorly understood as a mechanism impacting biogeochemical cycling in soil. Lack of detailed knowledge of soil abiotic–biotic interactions underlying trampling effects, and the primary sources of ...
G. Adam Meyer, Shawn J. Leroux, Kathryn E. Hargan, Niels van Miltenburg   +3 more
wiley   +1 more source

Of guinea pigs and men [PDF]

Nature Methods, 2005
openaire   +2 more sources

Antimicrobial Use in Livestock: The Economic Cost of Action or Inaction

Journal of Agricultural Economics, EarlyView.
ABSTRACT This paper quantifies the economy‐wide consequences of two independent global stress‐tests in livestock production. The first assesses the effects of phasing out antimicrobial growth promoters (AGPs), and the second evaluates the long‐term impacts of antimicrobial resistance (AMR) progression.
Alejandro Acosta, Wondmagegn Tirkaso, Marco Artavia, Francesco Nicolli, Thomas Chatzopoulos, Sergio René Araujo‐Enciso, Martin Cicowiez, Shaikh Eskander, Ramanan Laxminarayan, Junxia Song   +9 more
wiley   +1 more source

Role of ANO1‐Expressing PDGFRα+ Smooth Muscle Cells in Generating Spontaneous Phasic Contractions of the Rodent Epididymis

Andrology, EarlyView.
ABSTRACT Background Spontaneous phasic contractions (SPCs) in the epididymal duct play an important role in transport and maturation of sperm. In proximal cauda of the rat epididymis, platelet‐derived growth factor receptor α (PDGFRα)‐positive smooth muscle cells (SMCs) generate ANO1 Ca2+‐activated chloride channels (CaCCs)‐dependent spontaneous ...
Wataru Kudo, Hiromichi Takano, Toshiya Izuchi, Retsu Mitsui, Kyoko Miwa‐Nishimura, Hikaru Hashitani   +5 more
wiley   +1 more source

Generative artificial intelligence in higher education: Emotional tensions and ethical declaration

British Journal of Educational Technology, EarlyView.
Abstract The increasing use of Generative Artificial Intelligence (GenAI) tools such as ChatGPT in higher education has raised questions about authorship, ethical responsibility, and academic transparency. While institutional guidelines exist, many remain vague and ineffective, leaving students to interpret disclosure obligations on their own.
Yao Qu, Hui En Loo, Jue Wang
wiley   +1 more source

Neuronal and ion channel mechanisms of noxious heat sensing in mammals: A puzzle of sensory physiology and pharmacology

British Journal of Pharmacology, EarlyView.
Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
wiley   +1 more source

The discovery and development of ensifentrine: A novel inhaled dual PDE3/4 inhibitor having ‘bifunctional’ bronchodilator and anti‐inflammatory activity

British Journal of Pharmacology, EarlyView.
Abstract Ensifentrine (formerly called RPL 554) is a novel, first in class, inhaled bifunctional dual PDE3/4 inhibitor for the treatment of chronic respiratory diseases. Ensifentrine exhibits both bronchodilation via PDE3 inhibition and anti‐inflammatory activity via PDE4 inhibition.
Clive Page
wiley   +1 more source

Muscarinic agonists for schizophrenia: Bridging preclinical evidence and clinical enthusiasm

British Journal of Pharmacology, EarlyView.
Abstract Antipsychotic drugs targeting dopamine receptors have been used to treat schizophrenia for decades, primarily alleviating positive symptoms such as hallucinations and delusions. However, they provide limited benefit for cognitive and negative symptoms—major contributors to poor outcomes—and are frequently associated with significant side ...
Brian J. Morris, Judith A. Pratt
wiley   +1 more source