Results 81 to 90 of about 164,248 (309)
Humans are not unique: difficult birth is common in placental mammals
Biological Reviews, EarlyView.ABSTRACT Human childbirth is widely presumed to be uniquely difficult and dangerous compared to birth in other mammals. Tight fetopelvic proportions can result in obstructed labour and contribute to high rates of maternal and neonatal mortality. Ideas summarised under the ‘obstetrical dilemma’ have contributed to this assumption by explaining difficult
Nicole D. S. Grunstra
wiley +1 more source
Antigen-Specific Single B Cell Sorting and Monoclonal Antibody Cloning in Guinea Pigs
Frontiers in Microbiology, 2019 Here, we have established an antigen-specific single B cell sorting and monoclonal antibody (mAb) cloning platform for analyzing immunization- or viral infection-elicited antibody response at the clonal level in guinea pigs.
Lin Lei +9 more
doaj +1 more source
RORγt‐APCs: The New Masters of Oral Tolerance
Barrier Immunity, EarlyView.ABSTRACT Oral tolerance is defined by the hypo‐responsiveness of our body to fed antigens, and its failure can lead to immune‐mediated diseases, such as allergy, chronic inflammation and autoimmune diseases. Decades of research have demonstrated that antigen‐presenting cells (APCs) promote oral tolerance by inducing regulatory T cells (Tregs) and/or ...
Thierry Gauthier, WanJun Chen
wiley +1 more source
Journal of Pharmacological Sciences, 2008 The contribution of the T-type Ca2+ current to cardiac pacemaking was examined in isolated right atrial tissue from the mouse, guinea pig, and rabbit using a specific blocker, R(−)-efonidipine.
Hikaru Tanaka +7 more
doaj +1 more source
Epilepsia, EarlyView.Abstract Heterozygous loss‐of‐function variants in the gene SCN1A, which encodes the voltage‐gated sodium channel (VGSC) pore‐forming (α) subunit NaV1.1, lead to a spectrum of neurological disease, including Dravet syndrome. NaV1.1 is prominently expressed at the proximal portion of the axon initial segment (AIS) of fast‐spiking γ‐aminobutyric ...
Ania K. Dabrowski +4 more
wiley +1 more source
Providing Homes For The Homeless - The Viable Alternative [PDF]
Tropicultura, 1994 Guinea pig Cavia porcellus farming for meat production remains a marginalised activity in Cameroon in spite of the advantages this specie offers. With the view to promote its production, a national countrywide survey was carried out in order to evaluate ...
Herbstein, D.
doaj
Frequency of Owner-Reported Bacterial Infections in Pet Guinea Pigs
Animals, 2019 Domestic guinea pigs suffer morbidity and mortality due to a range of bacterial infections amongst other causes. Microorganisms such as Bordetella bronchiseptica and Streptococcus pneumoniae are commonly implicated in respiratory disease; however, there ...
Shannon Roberts-Steel +3 more
doaj +1 more source
, 1981 The purpose of this study was to determine if antisera to an heterologous insulin could replace specific anti-guinea pig insulin serum for immunoperoxidase localization of guinea pig B cells.
K C Gorray, D G Baskin, W Y Fujimoto
core +1 more source
Smart Nanodelivery Systems for Immunometabolic Modulation in Osteoarthritis
Exploration, EarlyView.Smart nanodelivery systems deliver therapeutic payloads across the cartilage matrix to ensure their sustained accumulation within chondrocytes at sites of injury. By targeting specific molecular targets and signaling pathways, these platforms modulate the pathological synovium‐cartilage axis to restore immunometabolic homeostasis and drive tissue ...
Qirui Zhao +20 more
wiley +1 more source
Comparative analysis of rodent lens morphometrics and biomechanical properties
Frontiers in OphthalmologyIntroductionProper ocular lens function requires biomechanical flexibility, which is reduced during aging. As increasing lens size has been shown to correlate with lens biomechanical stiffness in aging, we tested the hypothesis that whole lens size ...
Sepideh Cheheltani +9 more
doaj +1 more source