Results 141 to 150 of about 135,352 (264)

Deciphering pro‐arrhythmogenic mechanisms of EPAC in human atrial cardiomyocytes

The Journal of Physiology, EarlyView.
Abstract figure legend This study aimed to investigate the effect of exchange proteins directly activated by cAMP (EPAC) on the regulation of human atrial cardiomyocyte electrophysiology and their potential involvement in the onset of atrial fibrillation (AF).
Arthur Boileve, Margaux Aize, Maximin Détrait, Laura Brard, Adrien Leboyer, Pierre‐Antoine Dupont, Alexandre Lebrun, Vladimir Saplacan, Christophe Simard, Fabien Brette, Frank Lezoualc'h, Laurent Sallé   +11 more
wiley   +1 more source

Chamber-specific transcriptomic insight into cardiac development using guinea pig and human heart tissue. [PDF]

Physiol Genomics
Salameh S, Guerrelli D, Swift LM, Haski A, Bruce A, Desai M, d'Udekem Y, Posnack NG.   +7 more
europepmc   +1 more source

Anatomical and functional mapping of vagal nociceptive sensory nerve subsets innervating the mouse lower airways by intersectional genetics

The Journal of Physiology, EarlyView.
Abstract figure legend We used an intersectional approach with recombinase‐expressing mice and adeno‐associated virus to map and modulate distinct nociceptive afferents in the vagal ganglia. TRPV1+P2X2+ neurons resided in the nodose ganglion (N), innervated the lungs (many projected into the alveoli) but not the trachea, and projected to the nucleus ...
Mayur J. Patil, Justin Shane Hooper, Seol‐Hee Kim, Parmvir K. Bahia, Nika Pavelkova, Sanjay S. Nair, Teresa S. Darcey, Karina V. Lurye, Meghana Madaram, Jailene Fiallo, Stephen H. Hadley, Thomas E. Taylor‐Clark   +11 more
wiley   +1 more source

Knockout of key receptors (PDGFRA and NRP2) in the guinea pig model blocks direct and endocytic pathways of CMV cell entry. [PDF]

J Gen Virol
Qin Y, Choi KY, El-Hamdi N, McGregor A.
europepmc   +1 more source

Glucocorticoids modulate drug transporter function in human fetal brain endothelial cells

The Journal of Physiology, EarlyView.
Abstract figure legend P‐glycoprotein and breast cancer resistance protein are the most prominent drug transporters at the fetal blood–brain barrier. We isolated primary human fetal brain endothelial cells from early and mid‐gestation cerebral microvessels and exposed them to glucocorticoids cortisol and dexamethasone in vitro.
Nikola Ivanovski, Phetcharawan Lye, Enrrico Bloise, Stephen G. Matthews   +3 more
wiley   +1 more source

Viral lineage and mode of exposure modulate within-host spatial dynamics of influenza A viruses in a guinea pig model. [PDF]

J Virol
Leyson CM, Vargas-Maldonado N, Gaddy M, Raghunathan V, Ferreri LM, Sethi M, Patatanian K, Carnaccini S, Ganti K, VanInsberghe D, Lowen AC.   +10 more
europepmc   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Sexual Shape Variation and Allometric Effects in Guinea Pig (<i>Cavia porcellus</i>) Skulls. [PDF]

Animals (Basel)
Yalin EE, Szara T, Günay E, Pešić A, Manuta N, Güzel BC, Temir MT, Gündemir O.   +7 more
europepmc   +1 more source

Skeletal muscle adaptation to muscle activity and hypoxia: Differential structural and metabolic remodelling

The Journal of Physiology, EarlyView.
Abstract figure legend There has been controversy about the structural (capillary) response of skeletal muscle to altered O2 status, involving decreased supply (hypoxia) or increased demand (activity). Here we demonstrate that seven days of activation of skeletal muscle by indirect electrical stimulation led to significant expansion of the capillary ...
David Hauton, Roger W.P. Kissane, James McCullagh, Stuart Egginton   +3 more
wiley   +1 more source

Turnover Rate of Lipids, Metabolites and Proteins Revealed by 156-Day-Long D₂O Administration in a Guinea Pig. [PDF]

Int J Mol Sci
Kostyukevich Y, Malyukova A, Malyshev N, Vishnevskaya A, Levashova A, Kovalenko A, Kireev A, Meshcherov A, Borisova L, Tupertsev B, Bashilov A, Osipenko S.   +11 more
europepmc   +1 more source