Results 161 to 170 of about 144,138 (264)

CD31⁺ Cell Enrichment Enhances Therapeutic Effects of Stromal Vascular Fraction in Experimental Primary Osteoarthritis: A Preclinical Study in the Dunkin Hartley Guinea Pig Model. [PDF]

Adv Sci (Weinh)
Zhou S, Winkler T, Chen B, Grzeski M, Yang Y, Fleckenstein FN, Geisel D, Hildebrandt A, Aschenbrenner D, Mohn MA, Claass B, Weiner J, Geissler S, Duda GN, Sheikh SP, Klein O, Maleitzke T.   +16 more
europepmc   +1 more source

Mechanisms underlying local Ca2+ signalling differences between right and left atrial myocytes at normal and increased frequencies

The Journal of Physiology, EarlyView.
Abstract figure legend Left atrial myocytes have TAT‐associated faster Ca2+ release but are more prone to maladaptation at higher frequencies due to weaker peripheral SR Ca2+ uptake and smaller trigger Ca2+ current. Abstract Changes in heart rate affect Ca2+ signalling and contractility in ventricular muscle, but the effects on atrial Ca2+ signalling ...
Joon‐Chul Kim, Hieu Trong Huynh, Phuong Kim Luong, Tran Nguyet Trinh, Yixuan Wu, Eleonora Grandi, Sun‐Hee Woo   +6 more
wiley   +1 more source

Intense pulsed light rejuvenates UVB-induced photoaging in human keratinocytes and guinea pig skin by inhibition of ERK-AP-1-MMP pathway. [PDF]

Sci Rep
Liu C, Hu W, Zhang X, Lu M, Xiang J, Tan L, Tao Y, Ma K, Zhang L, Yang Z, Gu W.   +10 more
europepmc   +1 more source

Deciphering pro‐arrhythmogenic mechanisms of EPAC in human atrial cardiomyocytes

The Journal of Physiology, EarlyView.
Abstract figure legend This study aimed to investigate the effect of exchange proteins directly activated by cAMP (EPAC) on the regulation of human atrial cardiomyocyte electrophysiology and their potential involvement in the onset of atrial fibrillation (AF).
Arthur Boileve, Margaux Aize, Maximin Détrait, Laura Brard, Adrien Leboyer, Pierre‐Antoine Dupont, Alexandre Lebrun, Vladimir Saplacan, Christophe Simard, Fabien Brette, Frank Lezoualc'h, Laurent Sallé   +11 more
wiley   +1 more source

Turnover Rate of Lipids, Metabolites and Proteins Revealed by 156-Day-Long D₂O Administration in a Guinea Pig. [PDF]

Int J Mol Sci
Kostyukevich Y, Malyukova A, Malyshev N, Vishnevskaya A, Levashova A, Kovalenko A, Kireev A, Meshcherov A, Borisova L, Tupertsev B, Bashilov A, Osipenko S.   +11 more
europepmc   +1 more source

Anatomical and functional mapping of vagal nociceptive sensory nerve subsets innervating the mouse lower airways by intersectional genetics

The Journal of Physiology, EarlyView.
Abstract figure legend We used an intersectional approach with recombinase‐expressing mice and adeno‐associated virus to map and modulate distinct nociceptive afferents in the vagal ganglia. TRPV1+P2X2+ neurons resided in the nodose ganglion (N), innervated the lungs (many projected into the alveoli) but not the trachea, and projected to the nucleus ...
Mayur J. Patil, Justin Shane Hooper, Seol‐Hee Kim, Parmvir K. Bahia, Nika Pavelkova, Sanjay S. Nair, Teresa S. Darcey, Karina V. Lurye, Meghana Madaram, Jailene Fiallo, Stephen H. Hadley, Thomas E. Taylor‐Clark   +11 more
wiley   +1 more source

Guinea Pig Model for Lassa Virus Infection of Reproductive Tract and Considerations for Sexual and Vertical Transmission. [PDF]

Emerg Infect Dis
Seixas JN, Gary JM, Welch SR, Genzer SC, Coleman-McCray JD, Harmon JR, Spiropoulou CF, Silva-Flannery L, Ficarra G, Lee E, Bhatnagar J, Spengler JR, Ritter JM.   +12 more
europepmc   +1 more source

Interplay between store‐operated calcium entry and mitochondrial phosphate handling modulates force and fatigue during exercise

The Journal of Physiology, EarlyView.
Abstract figure legend This study uses systems modelling to demonstrate a role of SOCE in sustained force generation during exercise. SOCE leads to two competing effects on contractile force in myofibres – increased cross‐bridge cycling due to elevated myoplasmic Ca2+$\text{Ca}^{2+}$ enhances force, whereas increased accumulation of myoplasmic ...
Emmet A. Francis, Juliette Hamid, Anusha Kumar, Padmini Rangamani   +3 more
wiley   +1 more source

Characterization of the Signaling Pathways Activated by KCl-Induced RTK Stimulation in Guinea Pig Airways. [PDF]

Biology (Basel)
Herrera-Alcibar E, Flores-Soto E, López RM, Castillo EF, Campos-Bedolla P, Carbajal V, Sommer B.   +6 more
europepmc   +1 more source

Glucocorticoids modulate drug transporter function in human fetal brain endothelial cells

The Journal of Physiology, EarlyView.
Abstract figure legend P‐glycoprotein and breast cancer resistance protein are the most prominent drug transporters at the fetal blood–brain barrier. We isolated primary human fetal brain endothelial cells from early and mid‐gestation cerebral microvessels and exposed them to glucocorticoids cortisol and dexamethasone in vitro.
Nikola Ivanovski, Phetcharawan Lye, Enrrico Bloise, Stephen G. Matthews   +3 more
wiley   +1 more source