Results 181 to 190 of about 164,248 (309)

Lipid metabolism related inflammation modulates ocular growth in a high-fat diet guinea pig model. [PDF]

J Transl Med
Zhang X, Chen Y, Wang K, Zhang N, Luan Z, Hao R.   +5 more
europepmc   +1 more source

Blue plaque review series: Thomas Graham Brown: Before his time

Experimental Physiology, EarlyView.
Abstract Thomas Graham Brown made a seminal discovery, published in 1911 while he was a Carnegie Fellow in the University of Liverpool laboratory of Nobel Prize winner Charles S. Sherrington. Working in cats, he showed that rhythmic ‘voluntary’ behaviour, such as stepping and, by inference, walking, does not result from a chain of reflex events, but ...
Ronald L. Calabrese, Eve Marder
wiley   +1 more source

Structural and functional foetal renal abnormalities as a mechanism of oligohydramnios in a guinea pig model of growth restriction. [PDF]

Sci Rep
Inatomi A, Katsura D, Tokoro S, Tanaka Y, Nakamura A, Hayashi K, Tsuji S.   +6 more
europepmc   +1 more source

The isolated working guinea pig heart: A functional and electrophysiological characterisation

Experimental Physiology, EarlyView.
Abstract Small animal isolated perfused hearts have been used for over 150 years for the study of cardiac physiology and pharmacology. The guinea pig heart represents the smallest mammalian heart that replicates key features of the human heart – for example, with respect to cardiac action potential duration, ion channel expression, excitation ...
Grace C. Anderson‐Barker, Michael J Shattock   +1 more
wiley   +1 more source

Structures of naked mole-rat, tuco-tuco, and guinea pig ribosomes-is rRNA fragmentation linked to translational fidelity? [PDF]

Nucleic Acids Res
Gutierrez-Vargas C, De S, Maji S, Liu Z, Ke Z, Nieß M, Seluanov A, Gorbunova V, Frank J.   +8 more
europepmc   +1 more source

Sympathetic stimulation can compensate for hypocalcaemia‐induced bradycardia in human and rabbit sinoatrial node cells

The Journal of Physiology, EarlyView.
Abstract figure legend AC: adenylyl cyclase, APT: adenosine triphosphate, AMP: adenosine monophosphate, cAMP: cyclic adenosine monophosphate, PDE: phosphodiesterase, PKA: protein kinase A, PPT: protein phosphatase, P: phosphorylation, RyR: ryanodine receptor, SERCA: sarcoplasmic/endoplasmic reticulum Ca2+‐adenosine triphosphatase, SR: sarcoplasmic ...
Moritz Linder, Tomas Stary, Gergő Bitay, Norbert Nagy, Axel Loewe   +4 more
wiley   +1 more source

Knockout of key receptors (PDGFRA and NRP2) in the guinea pig model blocks direct and endocytic pathways of CMV cell entry. [PDF]

J Gen Virol
Qin Y, Choi KY, El-Hamdi N, McGregor A.
europepmc   +1 more source

TMEM16A chloride channels in the female reproductive tract and their role in normal and dysfunctional pregnancy and labour

The Journal of Physiology, EarlyView.
Abstract figure legend TMEM16A plays a pivotal role in setting the duration of the action potential plateau in human uterine smooth muscle. An increase in TMEM16A expression in labour underpins a lengthening of the plateau and this provides time for the contraction to become larger and longer, important for timely successful labour.
Helena C. Parkington, Harold A. Coleman, Penelope M. Sheehan, Shaun P. Brennecke, Marianne Tare   +4 more
wiley   +1 more source

Viral lineage and mode of exposure modulate within-host spatial dynamics of influenza A viruses in a guinea pig model. [PDF]

J Virol
Leyson CM, Vargas-Maldonado N, Gaddy M, Raghunathan V, Ferreri LM, Sethi M, Patatanian K, Carnaccini S, Ganti K, VanInsberghe D, Lowen AC.   +10 more
europepmc   +1 more source

Novel volume‐electron microscopic ultrastructural analysis of gastrointestinal excitability associated with calcium–activated chloride channels

The Journal of Physiology, EarlyView.
Abstract figure legend Immunohistochemistry, electrophysiology and pharmacology are useful tools for understanding protein and channel expression and physiological reactions of calcium‐activated chloride channels (CaCCs). Conventional transmission electron microscopy has provided useful 2‐D information on organelle arrangement, localization and ...
Hiromi Tamada
wiley   +1 more source