Results 191 to 200 of about 144,138 (264)

Intracellular mechanosensation in intestinal smooth muscle: Piezo1 complexes amplify signalling beyond the surface

The Journal of Physiology, EarlyView.
Abstract figure legend Mechanosensation is not confined to the cell surface. In intestinal smooth muscle Piezo1 is predominantly intracellular (86%), where it forms a nanoscale (<40 nm) complex at the sarcoplasmic reticulum (SR)–plasma membrane junction. Within this sensor–amplifier–effector axis intra‐Piezo1 is the sensor that detects force at the SR,
Geoanna M. Bautista, Declan Manning, Emily C. Lieu, Stephanie I. Ugochukwu, Collin Matsumoto, Joshua P. Tulman, Miguel Martin‐Aragon Baudel, Nuria Daghbouche‐Rubio, Steven J. McElroy, Sal A. Baker, Manuel F. Navedo, L. Fernando Santana   +11 more
wiley   +1 more source

Optogenetic Infection and Optical Stimulation: A Study on Auditory Responses in Guinea Pig Cochlear Neurons. [PDF]

J Otol
Liu C, Yu N.
europepmc   +1 more source

Capture primed pluripotency in guinea pig. [PDF]

Stem Cell Reports
Guo J, Lin R, Liu J, Liu R, Chen S, Zhang Z, Yang Y, Wang H, Wang L, Yu S, Zhou C, Xiao L, Luo R, Yu J, Zeng L, Zhang X, Li Y, Wu H, Wang T, Li Y, Kumar M, Zhu P, Liu J.   +22 more
europepmc   +1 more source

hERG1 channels and potential therapeutics for long QT syndrome

The Journal of Physiology, EarlyView.
Abstract figure legend Prolonged QT results from hERG1 channel dysfunction. (A) Physiological anterograde trafficking of hERG1 channels to the plasma membrane, leading to a normal electrocardiogram. (B) Prolonged QT results from the presence of fewer hERG1 channels on the plasma membrane due to decreased anterograde trafficking or reduced function due ...
Elizabeth H. Schneider, Kelly A. Aromolaran, Michael C. Sanguinetti, Ademuyiwa S. Aromolaran   +3 more
wiley   +1 more source

Neurodevelopmental Changes in the Guinea Pig Brain Caused by Time-Limited Complete Vitamin C Deprivation. [PDF]

Nutrients
Čapo I, Andrijević I, Čapo N, Popović M, Milenković I, Ratajac R, Vranješ D, Milutinović D, Simin D, Sekulić S.   +9 more
europepmc   +1 more source

‘All of It Was Hard. And All of It Was Necessary’: A Reflexive Thematic Analysis of Service User Experience of Group Schema Therapy for Borderline Personality Disorder

Counselling and Psychotherapy Research, Volume 26, Issue 4, December 2026.
ABSTRACT Background Group Schema Therapy is supported by a good evidence base as an effective treatment for Borderline Personality Disorder. Though we are continuing to learn about its mechanisms of change and how it is experienced, published research has not yet explored the experiences of service users in UK Tier 3 mental health services.
Kathleen McGlynn, Emma Smith
wiley   +1 more source

Effects of fertilization media on in vitro embryonic development in red-rumped agouti () using a heterologous system with guinea pig oocytes. [PDF]

JBRA Assist Reprod
Oliveira LRM, Aquino LVC, Bezerra LGP, Oliveira MF, Silva AR, Pereira AF.   +5 more
europepmc   +1 more source

Myelin Maintenance and Addition Regulate Synaptic Plasticity in the Adult Mouse Cortex

Glia, Volume 74, Issue 12, December 2026.
We report that existing myelin allows neurons to remain plastic throughout life, while new myelin progressively stabilises synapses along the basal but not apical dendrites of layer V pyramidal neurons in the motor cortex. ABSTRACT Myelin has the capacity to affect synapse number or plasticity across the lifespan.
Renee E. Pepper, Kalina Makowiecki, Kimberley A. Pitman, Raphael Ricci, Angela L. Nicoli, Phuong Tram Nguyen, Catherine A. Blizzard, Ben Emery, Carlie L. Cullen, Kaylene M. Young   +9 more
wiley   +1 more source

Guinea Pig [PDF]

, 2021
openaire   +1 more source

Red Fluorescent Labeling of Myelin by Membrane‐Targeted tdTomato in Transgenic Mouse Lines

Glia, Volume 74, Issue 12, December 2026.
Transgenic mouse lines expressing membrane‐targeted tdTomato in myelin enable imaging of myelin in the red spectral range. Distinct expression patterns range from wide‐spread labeling to sparse single‐cell resolution, supporting diverse imaging applications.
Anja Reinert, Ulrike Winkler, Sandra Goebbels, Lina Komarek, Wiebke Möbius, Henri Seraf Zanker, Karl Schoknecht, Grit Bornschein, Hartmut Schmidt, Robert Fledrich, Ruth M. Stassart, Petra G. Hirrlinger, Klaus‐Armin Nave, Hauke B. Werner, Aiman S. Saab, Johannes Hirrlinger   +15 more
wiley   +1 more source