Results 141 to 150 of about 831,459 (395)

Regenerating the Senses: Stem Cell‐Derived Sensory Neurons and Functional Genomics in Neurological Disorders

open access: yesSensory Neuroscience, EarlyView.
ABSTRACT Sensory neuron disorders, such as peripheral neuropathies and trigeminal neuralgia, cause chronic pain and sensory dysfunction; however, regenerative treatments are limited. Human pluripotent stem cells (hPSCs) provide a powerful platform to model these diseases by generating functional sensory neuron subtypes, including nociceptors and ...
Pushpanathan Muthuirulan   +3 more
wiley   +1 more source

Advancing Tuberculosis Chemotherapy: Targeted Nanomedicines for the Mycobacterium TB Granuloma

open access: yesSmall, EarlyView.
This graphical abstract illustrates nanosystems used for targeted drug delivery into tuberculosis granulomas. It shows how targeting is influenced by size, pH, redox sensitivity, and surface charge. Various nanoparticles are incorporated with drugs to enhance penetration, stability, and release.
Shreya Ranjith Singh   +3 more
wiley   +1 more source

Auditory-somatosensory bimodal stimulation desynchronizes brain circuitry to reduce tinnitus in guinea pigs and humans

open access: yesScience Translational Medicine, 2018
Kendra L Marks   +6 more
semanticscholar   +1 more source

3D full‐field strain distribution across the osteochondral unit during osteoarthritis progression

open access: yesVIEW, EarlyView.
Strain patterns across the cartilage‐bone unit play an important role in the early changes that lead to osteoarthritis (OA). To investigate this, cartilage‐bone plugs from guinea pigs with a natural progression of OA were taken at different stages of the disease (pre‐OA, early‐stage OA and late‐stage OA) and subjected to loads equal to two (L1) or four
Sarah Davis   +4 more
wiley   +1 more source

A comparison of virulence of intraperitoneal infection of Burkholderia mallei strains in guinea-pigs

open access: yesArchives of Razi Institute, 2015
Male guinea pigs show high susceptibility to Burkholderia mallei and have been used as animal models in glanders studies. The purpose of our study was to elucidate glanders comparative pathogenesis in guinea pigs. We present here the histological changes
Eslampanah, M.   +2 more
doaj  

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