Results 31 to 40 of about 1,182 (140)

NDRG1‐Driven Lactate Accumulation Promotes Lung Adenocarcinoma Progression Through the Induction of an Immunosuppressive Microenvironment

Advanced Science, Volume 12, Issue 33, September 4, 2025.
NDRG1 drives lactate accumulation and histone lactylation in lung adenocarcinoma, promoting immunosuppression via M2 macrophage polarization and CD8⁺ T cell inhibition. High NDRG1 expression correlates with poor prognosis, an immunosuppressive microenvironment, and immunotherapy resistance.
Gujie Wu, Hongxia Cheng, Jiacheng Yin, Yuansheng Zheng, Haochun Shi, Binyang Pan, Ming Li, Mengnan Zhao, Jiaqi Liang, Yunyi Bian, Guangyao Shan, Guoshu Bi, Weigang Guo, Lin Wang, Yiwei Huang   +14 more
wiley   +1 more source

Key regulatory challenges in developing modified new chemical drugs in China: a national survey study

Frontiers in Pharmacology
ObjectiveWith the increasing number of modified new chemical drugs (MNCDs) entering the market or in the approval pipeline in China, understanding their current status is crucial.
Lixia Fu, Lixia Fu, Guoshu Jia, Guoshu Jia, Guoshu Jia, Minji Wei, Minji Wei, Yimin Cui, Yimin Cui, Yimin Cui, Yimin Cui   +10 more
doaj   +1 more source

A Method for Improving Permeability Accuracy of Tight Sandstone Gas Reservoirs Based on Core Data and NMR Logs

Energies, 2019
Accurate calculation of the permeability of tight sandstone gas reservoirs has been a challenge, due to the enhanced effect of pore structure. Reservoir permeability with the same porosity and different pore structure often varies greatly.
Liang Liu, Heping Pan, Chengxiang Deng, Guoshu Huang   +3 more
doaj   +1 more source

Efficacy, Quality of Life, and Cost‐Effectiveness of Superselective Adrenal Arterial Embolization in Idiopathic Hyperaldosteronism: A Comparative Study

The Journal of Clinical Hypertension, Volume 27, Issue 8, August 2025.
ABSTRACT Idiopathic hyperaldosteronism (IHA) is the most common subtype of primary aldosteronism, typically managed with mineralocorticoid receptor antagonists (MRAs). However, long‐term MRA therapy is associated with suboptimal cardiovascular outcomes and adverse effects.
Nouman Ali Khan, Min Mao, Rui Feng, Zhong Zuo, Muhammad Arif Asghar, Li Tao, Yongpeng Zhao, Ping Tang, Zhixing Xu, Jie Chen, Xin Li, Hong Zhao, Qiuyue Shi, Ling Wang, Yutian He, Jing Chang, Rui Xiang   +16 more
wiley   +1 more source

Unraveling multi‐scale neuroimaging biomarkers and molecular foundations for schizophrenia: A combined multivariate pattern analysis and transcriptome‐neuroimaging association study

CNS Neuroscience &Therapeutics, Volume 30, Issue 8, August 2024.
Our study highlights the potential of multi‐scale ReHo analysis as a valuable neuroimaging biomarker in the diagnosis of schizophrenia. Furthermore, we observed spatial scale‐dependent differences in enriched biological processes in the brain associated with schizophrenia.
Yanmin Peng, Chao Chai, Kaizhong Xue, Jie Tang, Sijia Wang, Qian Su, Chongjian Liao, Guoshu Zhao, Shaoying Wang, Nannan Zhang, Zhihui Zhang, Minghuan Lei, Feng Liu, Meng Liang   +13 more
wiley   +1 more source

The impact of short videos on young people’s willingness to engage in martial arts: establishing and testing a conditional process model

Humanities & Social Sciences Communications
Short videos, as a widely used form of social media among adolescents, currently lack validated methods to ascertain whether viewing these videos fosters a corresponding willingness to learn.
Hao Zeng, Guangyuan Yao, Xiujie Ma
doaj   +1 more source

Mechanism of ATS-induced flower thinning in Weihai Gold apple revealed by metabolomics analysis [PDF]

Guoshu xuebao
[Objective] The experiment was conducted to explore the secondary differential metabolites of Weihaijin apple after ammonium thiosulfate (ATS) treatment and its mechanism of flower thinning, and to provide scientific basis for efficient and high-quality ...
YANG Mengyu, DU Jie, WANG Laiping, WANG Guiping, CHEN Ru, XUE Xiaomin   +5 more
doaj   +1 more source

Single‐cell analysis uncovers high‐proliferative tumour cell subtypes and their interactions in the microenvironment of gastric cancer

Journal of Cellular and Molecular Medicine, Volume 28, Issue 12, June 2024.
Abstract Gastric cancer (GC) remains a prominent malignancy that poses a significant threat to human well‐being worldwide. Despite advancements in chemotherapy and immunotherapy, which have effectively augmented patient survival rates, the mortality rate associated with GC remains distressingly high. This can be attributed to the elevated proliferation
Wenjia Zhang, Xiaojing Wang, Jiaxing Dong, Kai Wang, Wanju Jiang, Chenchen Fan, Haitao Liu, Lihong Fan, Lei Zhao, Guoshu Li   +9 more
wiley   +1 more source

Effects of tai chi, ba duan jin, and walking on the mental health status of urban older people living alone: the mediating role of social participation and the moderating role of the exercise environment

Frontiers in Public Health
With the global trend of aging, lacking of interpersonal communication and spiritual support and companionship have had a great impact on the mental health of older people living alone. This study examines the multifaceted impacts of engaging in tai chi,
Baoyuan Wu, Guoyan Xiong, Peng Zhang, Xiujie Ma, Xiujie Ma   +4 more
doaj   +1 more source

Simulation of frost damage on overwintering fruiting parent branches in Actinidia arguta [PDF]

Guoshu xuebao
[Objective] This study explored low-temperature damage in Actinidia arguta to provide reference for freeze protection. [Methods] The MSX-2F artificial frost simulation chamber system was employed to simulate both historical low-temperature frost damage ...
QU Jing, WANG Nan, LI Sihu, LI Hualong, WU Jinwen   +4 more
doaj   +1 more source